Influence of Protein Corona on the Transport of Molecules into Cells by Mesoporous Silica Nanoparticles

2013 ◽  
Vol 5 (17) ◽  
pp. 8387-8393 ◽  
Author(s):  
Amauri J. Paula ◽  
Roberto T. Araujo Júnior ◽  
Diego Stéfani T. Martinez ◽  
Edgar J. Paredes-Gamero ◽  
Helena B. Nader ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona

Toxicity and mechanism of mesoporous silica nanoparticles in eyes

Nanoscale ◽  
2020 ◽  
Vol 12 (25) ◽  
pp. 13637-13653 ◽  
Author(s):  
Xia Chen ◽  
Shuang Zhu ◽  
Xisu Hu ◽  
Dayu Sun ◽  
Junling Yang ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Dry Eye ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Large Surface Area ◽  
Corneal Damage

It aims to explore the toxicity and mechanism of large-surface-area MSiNPs and MSiNPs-Ag+ exposed to hCEC cells and cornea. A protein corona-based therapy was proposed to treat MSiNPs and MSiNPs-Ag+ induced corneal damage and dry eye.

Magnetite mesoporous silica nanoparticles embedded in carboxybetaine methacrylate for application in hyperthermia and drug delivery

2020 ◽  
Vol 44 (20) ◽  
pp. 8232-8240 ◽  
Author(s):  
Hasan Keshavarz ◽  
Alireza Khavandi ◽  
Somaye Alamolhoda ◽  
M. Reza Naimi-Jamal
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Target Tissue ◽  
Burst Effect

Magnetite mesoporous silica nanoparticles (MMSNs) are biocompatible and can easily deliver a drug to the target tissue, but there are two challenges: burst effect and protein corona.

scholarly journals Effect of surface properties in protein corona development on mesoporous silica nanoparticles

RSC Advances ◽  
2014 ◽  
Vol 4 (55) ◽  
pp. 29134-29138 ◽  
Author(s):  
Alden M. Clemments ◽  
Carlos Muniesa ◽  
Christopher C. Landry ◽  
Pablo Botella
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Surface Properties ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Surface Modifications ◽  
Effect Of Surface

The composition of the protein corona formed on mesoporous silica nanoparticles with several surface modifications was characterized.

scholarly journals Suppression of the hemolytic effect of mesoporous silica nanoparticles after protein corona interaction: independence of the surface microchemical environment

2012 ◽  
Vol 23 (10) ◽  
pp. 1807-1814 ◽  
Author(s):  
Amauri J. Paula ◽  
Diego Stéfani T. Martinez ◽  
Roberto T. Araujo Júnior ◽  
Antonio G. Souza Filho ◽  
Oswaldo L. Alves
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Hemolytic Effect

Monitoring the Hemolytic Effect of Mesoporous Silica Nanoparticles after Human Blood Protein Corona Formation

2015 ◽  
Vol 2015 (27) ◽  
pp. 4595-4602 ◽  
Author(s):  
Diego Stéfani T. Martinez ◽  
Amauri J. Paula ◽  
Leandro C. Fonseca ◽  
Luis Augusto V. Luna ◽  
Camila P. Silveira ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Human Blood ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Blood Protein ◽  
Corona Formation ◽  
Hemolytic Effect

scholarly journals Protein Corona over Mesoporous Silica Nanoparticles: Influence of the Pore Diameter on Competitive Adsorption and Application to Prostate Cancer Diagnostics

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 8852-8861 ◽  
Author(s):  
Carla Vidaurre-Agut ◽  
Eva Rivero-Buceta ◽  
Eva Romaní-Cubells ◽  
Alden M. Clemments ◽  
César David Vera-Donoso ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Competitive Adsorption ◽  
Pore Diameter ◽  
Mesoporous Silica Nanoparticles ◽  
Protein Corona ◽  
Cancer Diagnostics

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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