Enzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-protein block copolymers

2009 ◽  
pp. 7104 ◽  
Author(s):  
Han-Nah Kim ◽  
Jin Lee ◽  
Hae-Yeong Kim ◽  
Young-Rok Kim
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Protein Block

scholarly journals Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5147
Author(s):  
Wanting Hou ◽  
Ruiqi Liu ◽  
Siwei Bi ◽  
Qian He ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Medical Applications ◽  
Drug Molecules ◽  
Reversible Addition ◽  
Raft Agent

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.

A pH-sensitive nano drug delivery system of doxorubicin-conjugated amphiphilic polyrotaxane-based block copolymers

2013 ◽  
Vol 1 (12) ◽  
pp. 1282 ◽  
Author(s):  
Lan Jiang ◽  
Ze-ming Gao ◽  
Lin Ye ◽  
Ai-ying Zhang ◽  
Zeng-guo Feng
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Nano Drug Delivery

scholarly journals Chemo-enzymatic Synthesis of Ester-Linked Docetaxel-Glycoside Conjugate and its Drug Delivery System Using Hybrid-Bio-Nanocapsules Targeted With Trastuzumab and Cetuximab

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1985880
Author(s):  
Yuya Fujitaka ◽  
Hiroki Hamada ◽  
Hatsuyuki Hamada ◽  
Noriyoshi Masuoka ◽  
Kei Shimoda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Growth ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Effective Suppression ◽  
Anti Cancer ◽  
Cancer Activity

Synthesis of ester-linked glucoside conjugate of docetaxel, 7-propionyldocetaxel 3''- O-α-D-glucopyranoside, was carried out by chemo-enzymatic procedures. The EE and LE values for hybrid-bio-nanocapsules of 7-propionyldocetaxel 3''- O-α-D-glucopyranoside were much improved rather than those of docetaxel. The hybrid-bio-nanocapsules targeted with trastuzumab and cetuximab, which contained 7-propionyldocetaxel 3''- O-α-D-glucopyranoside, showed high in vivo anti-cancer activity, ie, effective suppression of tumor growth, respectively.

scholarly journals Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer

2015 ◽  
Vol 3 (12) ◽  
pp. 2472-2486 ◽  
Author(s):  
Yuning Zhang ◽  
Pontus Lundberg ◽  
Maren Diether ◽  
Christian Porsch ◽  
Caroline Janson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Block Copolymers ◽  
Click Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
3D Models ◽  
Copolymer Micelles ◽  
2D And 3D

Histamine functionalized block copolymers were prepared with different ratios of histamine and octyl or benzyl groups using UV-initiated thiol-ene click chemistry.

scholarly journals Chemo-Enzymatic Synthesis of Glycolyl-Ester-Linked Taxol-Monosaccharide Conjugate and Its Drug Delivery System Using Hepatitis B Virus Envelope L Bio-Nanocapsules

2012 ◽  
Vol 5 ◽  
pp. BCI.S9824
Author(s):  
Kei Shimoda ◽  
Manabu Hamada ◽  
Masaharu Seno ◽  
Tadakatsu Mandai ◽  
Hiroki Hamada
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Water Solubility ◽  
Virus Envelope ◽  
B Virus

Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2′- O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2′- O-α-D-glucoside (21 μM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2′- O-α-D-glucoside to human hepatocellular carcinoma NuE cells.

Sustained drug delivery system for insulin using supramolecular hydrogels composed of tri-block copolymers

2016 ◽  
Vol 47 (3) ◽  
pp. 263-273 ◽  
Author(s):  
Elham Khodaverdi ◽  
Melika Javan ◽  
Sayyed A. Sajadi Tabassi ◽  
Bahman Khameneh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sustained Drug Delivery

scholarly journals Synthesis of Ester-linked Docetaxel-glycoside Conjugate and Its Application to Drug Delivery System using Immunoliposome Targeted with Trastuzumab

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Hiroki Hamada ◽  
Shouta Okada ◽  
Kei Shimoda ◽  
Hatsuyuki Hamada ◽  
Noriyoshi Masuoka
Keyword(s):  
Drug Delivery ◽  
Tumor Growth ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Water Solubility ◽  
Effective Suppression

Chemo-enzymatic synthesis of the ester-linked monosaccharide conjugate of docetaxel, 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside, was achieved by using lactase as a biocatalyst. The water-solubility and, EE and LE values for the liposome of 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside were much higher than those of docetaxel. The immunoliposome containing 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside showed effective suppression of tumor growth.

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