Synthesis of Hyperbranched Multiarm Star Block Copolymers and Their Application as a Drug-Delivery System

2013 ◽  
Vol 32 (4) ◽  
Author(s):  
Li Xia ◽  
Zhiping Zhou ◽  
Jiangdong Dai
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Star Block Copolymers

scholarly journals Photo-Responsive Polymersomes as Drug Delivery System for Potential Medical Applications

Molecules ◽  
2020 ◽  
Vol 25 (21) ◽  
pp. 5147
Author(s):  
Wanting Hou ◽  
Ruiqi Liu ◽  
Siwei Bi ◽  
Qian He ◽  
Haibo Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Raft Polymerization ◽  
Amphiphilic Block Copolymers ◽  
Medical Applications ◽  
Drug Molecules ◽  
Reversible Addition ◽  
Raft Agent

Due to a strong retardation effect of o-nitrobenzyl ester on polymerization, it is still a great challenge to prepare amphiphilic block copolymers for polymersomes with a o-nitrobenzyl ester-based hydrophobic block. Herein, we present one such solution to prepare amphiphilic block copolymers with pure poly (o-nitrobenzyl acrylate) (PNBA) as the hydrophobic block and poly (N,N’-dimethylacrylamide) (PDMA) as the hydrophilic block using bulk reversible addition-fragmentation chain transfer (RAFT) polymerization of o-nitrobenzyl acrylate using a PDMA macro-RAFT agent. The developed amphiphilic block copolymers have a suitable hydrophobic/hydrophilic ratio and can self-assemble into photoresponsive polymersomes for co-loading hydrophobic and hydrophilic cargos into hydrophobic membranes and aqueous compartments of the polymersomes. The polymersomes demonstrate a clear photo-responsive characteristic. Exposure to light irradiation at 365 nm can trigger a photocleavage reaction of o-nitrobenzyl groups, which results in dissociation of the polymersomes with simultaneous co-release of hydrophilic and hydrophobic cargoes on demand. Therefore, these polymersomes have great potential as a smart drug delivery nanocarrier for controllable loading and releasing of hydrophilic and hydrophobic drug molecules. Moreover, taking advantage of the conditional releasing of hydrophilic and hydrophobic drugs, the drug delivery system has potential use in medical applications such as cancer therapy.

A pH-sensitive nano drug delivery system of doxorubicin-conjugated amphiphilic polyrotaxane-based block copolymers

2013 ◽  
Vol 1 (12) ◽  
pp. 1282 ◽  
Author(s):  
Lan Jiang ◽  
Ze-ming Gao ◽  
Lin Ye ◽  
Ai-ying Zhang ◽  
Zeng-guo Feng
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ph Sensitive ◽  
Nano Drug Delivery

scholarly journals Histamine-functionalized copolymer micelles as a drug delivery system in 2D and 3D models of breast cancer

2015 ◽  
Vol 3 (12) ◽  
pp. 2472-2486 ◽  
Author(s):  
Yuning Zhang ◽  
Pontus Lundberg ◽  
Maren Diether ◽  
Christian Porsch ◽  
Caroline Janson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Block Copolymers ◽  
Click Chemistry ◽  
Drug Delivery System ◽  
Delivery System ◽  
3D Models ◽  
Copolymer Micelles ◽  
2D And 3D

Histamine functionalized block copolymers were prepared with different ratios of histamine and octyl or benzyl groups using UV-initiated thiol-ene click chemistry.

Sustained drug delivery system for insulin using supramolecular hydrogels composed of tri-block copolymers

2016 ◽  
Vol 47 (3) ◽  
pp. 263-273 ◽  
Author(s):  
Elham Khodaverdi ◽  
Melika Javan ◽  
Sayyed A. Sajadi Tabassi ◽  
Bahman Khameneh ◽  
Hossein Kamali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymers ◽  
Drug Delivery System ◽  
Delivery System ◽  
Sustained Drug Delivery

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug
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