scholarly journals Chemo-Enzymatic Synthesis of Glycolyl-Ester-Linked Taxol-Monosaccharide Conjugate and Its Drug Delivery System Using Hepatitis B Virus Envelope L Bio-Nanocapsules

2012 ◽  
Vol 5 ◽  
pp. BCI.S9824
Author(s):  
Kei Shimoda ◽  
Manabu Hamada ◽  
Masaharu Seno ◽  
Tadakatsu Mandai ◽  
Hiroki Hamada
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Water Solubility ◽  
Virus Envelope ◽  
B Virus

Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2′- O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2′- O-α-D-glucoside (21 μM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2′- O-α-D-glucoside to human hepatocellular carcinoma NuE cells.

Novel Tissue and Cell Type-specific Gene / Drug Delivery System Using Surface Engineered Hepatitis B Virus Nano-particles

2004 ◽  
Vol 4 (2) ◽  
pp. 163-167 ◽  
Author(s):  
Tadanori Yamada ◽  
Masakazu Ueda ◽  
Masaharu Seno ◽  
Akihiko Kondo ◽  
Katsuyuki Tanizawa ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nano Particles ◽  
Specific Gene ◽  
Cell Type ◽  
B Virus ◽  
Cell Type Specific

scholarly journals Inducing oral immune regulation of hepatitis B virus envelope proteins suppresses the growth of hepatocellular carcinoma in mice

Cancer ◽  
2002 ◽  
Vol 94 (2) ◽  
pp. 406-414 ◽  
Author(s):  
Israel Gotsman ◽  
Ruslana Alper ◽  
Athalia Klein ◽  
Elazar Rabbani ◽  
Dean Engelhardt ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Immune Regulation ◽  
Envelope Proteins ◽  
Virus Envelope ◽  
B Virus

scholarly journals Synthesis of Ester-linked Docetaxel-glycoside Conjugate and Its Application to Drug Delivery System using Immunoliposome Targeted with Trastuzumab

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Hiroki Hamada ◽  
Shouta Okada ◽  
Kei Shimoda ◽  
Hatsuyuki Hamada ◽  
Noriyoshi Masuoka
Keyword(s):  
Drug Delivery ◽  
Tumor Growth ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Water Solubility ◽  
Effective Suppression

Chemo-enzymatic synthesis of the ester-linked monosaccharide conjugate of docetaxel, 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside, was achieved by using lactase as a biocatalyst. The water-solubility and, EE and LE values for the liposome of 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside were much higher than those of docetaxel. The immunoliposome containing 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside showed effective suppression of tumor growth.

scholarly journals Hepatitis B virus envelope proteins can serve as therapeutic targets embedded in the host cell plasma membrane

2020 ◽  
Author(s):  
Lili Zhao ◽  
Fuwang Chen ◽  
Oliver Quitt ◽  
Marvin Festag ◽  
Marc Ringelhan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cells ◽  
Plasma Membrane ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Recombinant Antibody ◽  
Envelope Proteins ◽  
Hbv Infection ◽  
Virus Envelope ◽  
B Virus

AbstractHepatitis B virus (HBV) infection is a major health threat causing 880,000 deaths each year. Available therapies control viral replication, but do not cure HBV leaving patients at risk to develop hepatocellular carcinoma. Here we show that HBV envelope proteins (HBs) - besides their integration into endosomal membranes - become embedded in the plasma membrane where they can be targeted by redirected T-cells. HBs was detected on the surface of HBV-infected cells, in livers of mice replicating HBV and in HBV-induced hepatocellular carcinoma. Staining with HBs-specific recombinant antibody MoMab recognizing a confirmational epitope indicated that membrane-associated HBs remains correctly folded in HBV-replicating cells in cell culture and in livers of HBV-transgenic mice in vivo. MoMab coated onto superparamagnetic iron oxide nanoparticles allowed to detect membrane-associated HBs after HBV infection by electron microscopy in distinct stretched of the hepatocyte plasma membrane. Last not least we demonstrate that HBs located to the cell surface allows therapeutic targeting of HBV-positive cells by T-cells either engrafted with a chimeric antigen receptor or redirected by bispecific, T-cell engager antibodies.

Role of environmental factors in the etiology of hepatocellular carcinoma

2010 ◽  
Vol 151 (28) ◽  
pp. 1132-1136 ◽  
Author(s):  
István Tornai
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Environmental Factors ◽  
Hepatitis B ◽  
Hepatitis A ◽  
Virus Hepatitis ◽  
B Virus

A krónikus vírushepatitisek jelentik ma a legismertebb okokat a hepatocellularis carcinoma (HCC) kialakulásában. A krónikus B- és C-vírus-hepatitis a májrákok körülbelül 40-50%-át okozza. A nyugati típusú társadalmakban a HCC előfordulása folyamatosan növekvő tendenciát mutat. Az alkohol számít a környezeti tényezők közül a legfontosabbnak, bár az alkoholfogyasztás a legtöbb országban csökken. Ez aláhúzza az egyéb környezeti tényezők fontosságát is. Az elfogyasztott alkoholmennyiséggel egyenes arányban növekszik a cirrhosis és a következményes HCC gyakorisága nőkben és férfiakban egyaránt. A kémiai anyagok közül a legismertebb a Kínában és Afrikában elterjedt aflatoxin, amely a gabonaféléket szennyező mycotoxin. Hasonló területeken endémiás, mint a hepatitis B-vírus, együtt szinergista hatást fejtenek ki. A dohányzás is egyértelműen bizonyított hepatocarcinogen hatással rendelkezik. Ez is jelentősen fokozódik, ha alkoholfogyasztással vagy vírushepatitisszel társul. Társadalmilag talán a legfontosabb az elhízás, a következményes nem alkoholos zsírmáj, illetve steatohepatitis és a 2-es típusú cukorbetegség, amelyek prevalenciája egyre fokozódik. Feltehetően ezek állnak a növekvő HCC-gyakoriság hátterében. Az inzulinrezisztencia és az oxidatív stressz képezik a legfontosabb patogenetikai lépéseket a májsejtkárosodásban. További fontos rizikótényező az orális fogamzásgátlók elterjedt használata. Egyes foglalkozások esetén a tartós szervesoldószer-expozíció is növeli a HCC rizikóját. Védelmet jelenthetnek az antioxidánsok, a szelén, a gyógyszerek közül a statinok és a feketekávé-fogyasztás.

Disparities in Time to Treatment of Hepatocellular Carcinoma in Patients with Hepatitis B Virus versus Hepatitis C Virus

2017 ◽  
Vol 05 (03) ◽  
Author(s):  
Jennifer Wu ◽  
Tsivia Hochman ◽  
Judith D Goldberg ◽  
Jafar Al Mondhiry ◽  
Bennal Perkins ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Time To Treatment ◽  
B Virus ◽  
Virus Versus

Integrated structures of duck hepatitis B virus DNA in hepatocellular carcinoma.

1988 ◽  
Vol 62 (3) ◽  
pp. 861-865 ◽  
Author(s):  
F Imazeki ◽  
K Yaginuma ◽  
M Omata ◽  
K Okuda ◽  
M Kobayashi ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Duck Hepatitis B Virus ◽  
Hepatitis B Virus Dna ◽  
Duck Hepatitis ◽  
B Virus ◽  
Integrated Structures
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