scholarly journals Chemo-enzymatic Synthesis of Propionyl-ester-linked Taxol-monosaccharide Conjugate and its Drug Delivery System Using Hybrid-Bio-nanocapsules Targeting Brain Glioma Cells

2013 ◽  
Vol 6 ◽  
pp. CMWH.S8213
Author(s):  
Hiroki Hamada ◽  
Kei Shimoda ◽  
Masaharu Seno
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Glioma Cells ◽  
Brain Glioma

Peptide-functionalized and high drug loaded novel nanoparticles as dual-targeting drug delivery system for modulated and controlled release of paclitaxel to brain glioma

2018 ◽  
Vol 553 (1-2) ◽  
pp. 169-185 ◽  
Author(s):  
Primiano Pio Di Mauro ◽  
Anna Cascante ◽  
Pau Brugada Vilà ◽  
Vanessa Gómez-Vallejo ◽  
Jordi Llop ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Brain Glioma ◽  
High Drug ◽  
Dual Targeting

scholarly journals Chemo-enzymatic Synthesis of Ester-Linked Docetaxel-Glycoside Conjugate and its Drug Delivery System Using Hybrid-Bio-Nanocapsules Targeted With Trastuzumab and Cetuximab

2019 ◽  
Vol 14 (6) ◽  
pp. 1934578X1985880
Author(s):  
Yuya Fujitaka ◽  
Hiroki Hamada ◽  
Hatsuyuki Hamada ◽  
Noriyoshi Masuoka ◽  
Kei Shimoda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tumor Growth ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Effective Suppression ◽  
Anti Cancer ◽  
Cancer Activity

Synthesis of ester-linked glucoside conjugate of docetaxel, 7-propionyldocetaxel 3''- O-α-D-glucopyranoside, was carried out by chemo-enzymatic procedures. The EE and LE values for hybrid-bio-nanocapsules of 7-propionyldocetaxel 3''- O-α-D-glucopyranoside were much improved rather than those of docetaxel. The hybrid-bio-nanocapsules targeted with trastuzumab and cetuximab, which contained 7-propionyldocetaxel 3''- O-α-D-glucopyranoside, showed high in vivo anti-cancer activity, ie, effective suppression of tumor growth, respectively.

scholarly journals Chemo-Enzymatic Synthesis of Glycolyl-Ester-Linked Taxol-Monosaccharide Conjugate and Its Drug Delivery System Using Hepatitis B Virus Envelope L Bio-Nanocapsules

2012 ◽  
Vol 5 ◽  
pp. BCI.S9824
Author(s):  
Kei Shimoda ◽  
Manabu Hamada ◽  
Masaharu Seno ◽  
Tadakatsu Mandai ◽  
Hiroki Hamada
Keyword(s):  
Hepatocellular Carcinoma ◽  
Drug Delivery ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Water Solubility ◽  
Virus Envelope ◽  
B Virus

Chemo-enzymatic synthesis of glycolyl-ester-linked taxol-glucose conjugate, ie, 7-glycolyltaxol 2′- O-α-D-glucoside, was achieved by using α-glucosidase as a biocatalyst. The water-solubility of 7-glycolyltaxol 2′- O-α-D-glucoside (21 μM) was 53 fold higher than that of taxol. The hepatitis B virus envelope L particles (bio-nanocapsules) are effective for delivering 7-glycolyltaxol 2′- O-α-D-glucoside to human hepatocellular carcinoma NuE cells.

scholarly journals Synthesis of Ester-linked Docetaxel-glycoside Conjugate and Its Application to Drug Delivery System using Immunoliposome Targeted with Trastuzumab

2016 ◽  
Vol 11 (11) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Hiroki Hamada ◽  
Shouta Okada ◽  
Kei Shimoda ◽  
Hatsuyuki Hamada ◽  
Noriyoshi Masuoka
Keyword(s):  
Drug Delivery ◽  
Tumor Growth ◽  
Drug Delivery System ◽  
Delivery System ◽  
Enzymatic Synthesis ◽  
Water Solubility ◽  
Effective Suppression

Chemo-enzymatic synthesis of the ester-linked monosaccharide conjugate of docetaxel, 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside, was achieved by using lactase as a biocatalyst. The water-solubility and, EE and LE values for the liposome of 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside were much higher than those of docetaxel. The immunoliposome containing 7-glycolyldocetaxel 2″- O-β-D-galactopyranoside showed effective suppression of tumor growth.

Hexosomes based on cholesterol and phosphatidylcholine: a new drug delivery system for curcumin release

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
AR Bilia ◽  
G Capecchi ◽  
MC Salvatici ◽  
B Isacchi ◽  
MC Bergonzi
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
New Drug
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