The facile synthesis of α-aryl-α-hydroxy esters via one-pot vicarious nucleophilic substitution and oxidation

1999 ◽  
pp. 689-690 ◽  
Author(s):  
Nicholas J. Lawrence ◽  
Olivier Lamarche ◽  
Nabil Thurrab
Keyword(s):  
Nucleophilic Substitution ◽  
Facile Synthesis ◽  
One Pot ◽  
Vicarious Nucleophilic Substitution ◽  
Hydroxy Esters

scholarly journals One-pot facile synthesis of 4-amino-1,8-naphthalimide derived Tröger's bases via a nucleophilic displacement approach

2017 ◽  
Vol 15 (35) ◽  
pp. 7321-7329 ◽  
Author(s):  
Sankarasekaran Shanmugaraju ◽  
Deirdre McAdams ◽  
Francesca Pancotti ◽  
Chris S. Hawes ◽  
Emma B. Veale ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Synthetic Strategy ◽  
Nucleophilic Displacement ◽  
Displacement Approach

We report here a novel one-pot synthetic strategy for the synthesis of a family of N-alkyl-1,8-naphthalimide derived Tröger's bases (in overall yield of 65–96%) via a nucleophilic substitution reaction.

One-Pot Synthesis of Oxiranes through Vicarious Nucleophilic Substitution (VNS)–Darzens Reaction

Synlett ◽  
2016 ◽  
Vol 27 (17) ◽  
pp. 2443-2446 ◽  
Author(s):  
Mieczysław Mąkosza ◽  
Arkadiusz Sakowicz ◽  
Rafał Loska
Keyword(s):  
Nucleophilic Substitution ◽  
Darzens Reaction ◽  
One Pot ◽  
Vicarious Nucleophilic Substitution ◽  
One Pot Synthesis

First Total Synthesis of a Cytotoxic Derivative of the Natural Product Aaptamine

Synthesis ◽  
2017 ◽  
Vol 49 (12) ◽  
pp. 2768-2774 ◽  
Author(s):  
Srinu Puvvala ◽  
Vinod Jadhav ◽  
Umesh Narkhede ◽  
M. Anji Karun ◽  
Ch. Venkata Ramana Reddy
Keyword(s):  
Total Synthesis ◽  
Nucleophilic Substitution ◽  
Natural Product ◽  
Ring Closure ◽  
One Pot ◽  
Vicarious Nucleophilic Substitution ◽  
Synthetic Sequence

A synthetic sequence to the benzonaphthyridinone framework is described. The key step is a one-pot, base-catalyzed vicarious nucleophilic substitution followed by ring closure. Additionally, the synthesis represents the application of a vicarious nucleophilic substitution in the total synthesis of a cytotoxic aaptamine derivative.

Synthesis of Pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by Alkyne-Carbonyl Metathesis

Synthesis ◽  
2020 ◽  
Author(s):  
Peter Ehlers ◽  
Peter Langer ◽  
Marian Blanco Ponce ◽  
Silvio Parpart ◽  
Alexander Villinger ◽  
...  
Keyword(s):  
Heterocyclic Compounds ◽  
Metathesis Reaction ◽  
Synthetic Methodology ◽  
Facile Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Metal Free ◽  
Modular Synthesis

AbstractA concise and modular synthesis of pyrrolo[1,2-a][1,6]- and [1,8]naphthyridines by a one-pot two-step reaction consisting of electrophilic acylation followed by an alkyne-carbonyl-metathesis reaction as the final cyclization step is reported. This developed synthetic methodology allows the facile synthesis of these heterocyclic core structures in mainly high overall yields under metal-free conditions. Reaction conditions are carefully optimized and display a novel supplement to access these tricyclic heterocyclic compounds.

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