One-Pot Synthesis of Esters of Cyclopropane Carboxylic Acids via Tandem Vicarious Nucleophilic Substitution–Michael Addition Process

2015 ◽  
Vol 80 (11) ◽  
pp. 5436-5443 ◽  
Author(s):  
Mieczysław Mąkosza ◽  
Karol Bester ◽  
Piotr Cmoch
Keyword(s):  
Nucleophilic Substitution ◽  
Carboxylic Acids ◽  
Michael Addition ◽  
One Pot ◽  
Vicarious Nucleophilic Substitution ◽  
One Pot Synthesis

One-Pot Synthesis of Oxiranes through Vicarious Nucleophilic Substitution (VNS)–Darzens Reaction

Synlett ◽  
2016 ◽  
Vol 27 (17) ◽  
pp. 2443-2446 ◽  
Author(s):  
Mieczysław Mąkosza ◽  
Arkadiusz Sakowicz ◽  
Rafał Loska
Keyword(s):  
Nucleophilic Substitution ◽  
Darzens Reaction ◽  
One Pot ◽  
Vicarious Nucleophilic Substitution ◽  
One Pot Synthesis

Catalyst-Free One-Pot Synthesis of Novel Heteroarylamine Substituted Furo[3,2-c]coumarins

Synlett ◽  
2018 ◽  
Vol 29 (12) ◽  
pp. 1589-1592 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Mahnaz Saraei ◽  
Reyhaneh Khoeiniha
Keyword(s):  
Michael Addition ◽  
Aldol Condensation ◽  
Ring Closure ◽  
Dehydration Reaction ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Tandem Process ◽  
First Time

A high-yielding cyclocondensation of 4-hydroxycoumarin, phenylglyoxal monohydrate, and heteroarylamines proceeds without catalysis, which gives novel functionalized furo[3,2-c]coumarins and heteroarylamino alkylation of coumarin products in acetonitrile under reflux, is reported for the first time. This tandem process involves sequentially an aldol condensation, Michael addition, a ring closure, and dehydration reaction.

One-Pot Synthesis of Highly Substituted Allenylidene Derivatives via Palladium- or Nickel-Catalyzed Tandem Michael Addition-Cyclization Reaction

2009 ◽  
Vol 351 (1-2) ◽  
pp. 141-146 ◽  
Author(s):  
Yun Shi ◽  
Jing Huang ◽  
Yan-Fang Yang ◽  
Lu-Yong Wu ◽  
Yan-Ning Niu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis

One-pot synthesis of amides from carboxylic acids activated using thionyl chloride

RSC Advances ◽  
2016 ◽  
Vol 6 (41) ◽  
pp. 34468-34475 ◽  
Author(s):  
A. Leggio ◽  
E. L. Belsito ◽  
G. De Luca ◽  
M. L. Di Gioia ◽  
V. Leotta ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Tertiary Amine ◽  
Thionyl Chloride ◽  
One Pot ◽  
One Pot Synthesis ◽  
Tertiary Amides

We report on a one-pot synthesis of secondary and tertiary amides from carboxylic acids and amines in the presence of a tertiary amine by using thionyl chloride.

A Highly Enantioselective One-Pot Synthesis of Spirolactones by an Organocatalyzed Michael Addition/Cyclization Sequence

2011 ◽  
Vol 50 (40) ◽  
pp. 9382-9385 ◽  
Author(s):  
Silvia Sternativo ◽  
Antonella Calandriello ◽  
Ferdinando Costantino ◽  
Lorenzo Testaferri ◽  
Marcello Tiecco ◽  
...  
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals A Synthesis of 4-Chloro-2-(trichloromethyl)pyrimidines and Their Study in Nucleophilic Substitution

Synthesis ◽  
2018 ◽  
Vol 51 (02) ◽  
pp. 530-537 ◽  
Author(s):  
Moisés Romero-Ortega ◽  
Michelle Trujillo-Lagunas ◽  
Ignacio Medina-Mercado ◽  
Ivann Zaragoza-Galicia ◽  
Horacio Olivo
Keyword(s):  
Nucleophilic Substitution ◽  
Intramolecular Cyclization ◽  
Nitrogen Heterocycles ◽  
Cyclization Reaction ◽  
Substitution Reactions ◽  
Pyrimidine Derivatives ◽  
One Pot ◽  
Acyl Chlorides ◽  
Nucleophilic Substitution Reactions ◽  
One Pot Synthesis

A convenient two-step, one-pot synthesis of 4-chloro-2-(trichloromethyl)pyrimidines starting from 2-(trichloromethyl)-1,3-diazabutadienes is described. These nitrogen heterocycles were prepared by a sequential acylation/intramolecular cyclization reaction between 2-(trichloromethyl)-1,3-diazabutadienes and acyl chlorides in the presence of triethylamine followed by treatment with POCl3. This is the first report for the synthesis of this type of 4-chloro-2-(trichloromethyl)pyrimidine derivatives and serves as a source for a wide variety of other substituted pyrimidines by nucleophilic substitution reactions.

Cu-Catalyzed one-pot synthesis of thiochromeno-quinolinone and thiochromeno-thioflavone via oxidative double hetero Michael addition using in situ generated nucleophiles

2020 ◽  
Vol 56 (62) ◽  
pp. 8826-8829
Author(s):  
Nallappan Sundaravelu ◽  
Govindasamy Sekar
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
One Pot Synthesis

A copper catalyzed three-component synthesis of π-conjugated tetracyclic thiochromeno-quinolinone and thiochromeno-thioflavone was established via oxidative double hetero Michael addition using in situ generated nucleophiles.

An Efficient One-Pot Synthesis of N-Methoxy-N-methylamides from Carboxylic Acids.

ChemInform ◽  
2004 ◽  
Vol 35 (12) ◽  
Author(s):  
Misoo Kim ◽  
Hagyoung Lee ◽  
Ki-Jong Han ◽  
Kwang-Yol Kay
Keyword(s):  
Carboxylic Acids ◽  
One Pot ◽  
One Pot Synthesis
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