scholarly journals One-pot facile synthesis of 4-amino-1,8-naphthalimide derived Tröger's bases via a nucleophilic displacement approach

2017 ◽  
Vol 15 (35) ◽  
pp. 7321-7329 ◽  
Author(s):  
Sankarasekaran Shanmugaraju ◽  
Deirdre McAdams ◽  
Francesca Pancotti ◽  
Chris S. Hawes ◽  
Emma B. Veale ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Facile Synthesis ◽  
One Pot ◽  
Synthetic Strategy ◽  
Nucleophilic Displacement ◽  
Displacement Approach

We report here a novel one-pot synthetic strategy for the synthesis of a family of N-alkyl-1,8-naphthalimide derived Tröger's bases (in overall yield of 65–96%) via a nucleophilic substitution reaction.

scholarly journals Direct synthesis of covalent triazine-based frameworks (CTFs) through aromatic nucleophilic substitution reactions

RSC Advances ◽  
2019 ◽  
Vol 9 (31) ◽  
pp. 18008-18012 ◽  
Author(s):  
Tao Chen ◽  
Wen-Qian Li ◽  
Wei-Bo Hu ◽  
Wen-Jing Hu ◽  
Yahu A. Liu ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Direct Synthesis ◽  
Nucleophilic Substitution Reaction ◽  
Substitution Reactions ◽  
Aromatic Nucleophilic Substitution ◽  
Nucleophilic Substitution Reactions ◽  
Synthetic Strategy ◽  
Aromatic Nucleophilic Substitution Reaction

Triazine-based frameworks (CTFs) were synthesized through a new synthetic strategy in which C–C bonds were formed through aromatic nucleophilic substitution reaction.

Synthesis of Cyanamides from Cyanogen Bromide under Mild Conditions through N-Cyanation of Allylic Tertiary Amines

Synlett ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 2675-2679 ◽  
Author(s):  
Chenghui Sun ◽  
Honggang Liang ◽  
Lingxiang Bao ◽  
Yao Du ◽  
Yiying Zhang ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Cyanogen Bromide ◽  
New Method ◽  
Nucleophilic Substitution Reaction ◽  
Tertiary Amines ◽  
Reaction Conditions ◽  
One Pot ◽  
Mild Conditions ◽  
One Step

Cyanamides were selectively formed through a one-step nucleophilic substitution reaction of allylic tertiary amines with cyanogen bromide. Because of the mild reaction conditions and good yields of the reaction, as well as the commercial availability of the starting materials, this new method represents a valuable tool for the synthesis of cyan­amides through an N-deallylation reaction and an N-cyanation reaction in one pot.

Azacalix[2]arene[2]carbazoles: synthesis, structure and properties

RSC Advances ◽  
2016 ◽  
Vol 6 (33) ◽  
pp. 27988-27992 ◽  
Author(s):  
Hui Xu ◽  
Fang-Jun Qian ◽  
Qiao-Xia Wu ◽  
Min Xue ◽  
Yong Yang ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Structure And Properties ◽  
Aromatic Nucleophilic Substitution ◽  
One Pot ◽  
Coupling Strategy ◽  
New Type ◽  
Aromatic Nucleophilic Substitution Reaction

A new type of –NH– bridged azacalix[2]arene[2]carbazoles has been synthesized by aromatic nucleophilic substitution reactionviaone pot and/or fragment coupling strategy.

scholarly journals Synthesis of Carbohydrate Based Macrolactones and Their Applications as Receptors for Ion Recognition and Catalysis

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3394
Author(s):  
Surya B. Adhikari ◽  
Anji Chen ◽  
Guijun Wang
Keyword(s):  
Nucleophilic Substitution ◽  
Supramolecular Chemistry ◽  
Copper Sulfate ◽  
Substitution Reaction ◽  
Biological Properties ◽  
Anion Binding ◽  
Nucleophilic Substitution Reaction ◽  
Binding Properties ◽  
Intramolecular Nucleophilic Substitution ◽  
Leaving Groups

Glycomacrolactones exhibit many interesting biological properties, and they are also important in molecular recognitions and for supramolecular chemistry. Therefore, it is important to be able to access glycomacrocycles with different sizes and functionality. A new series of carbohydrate-based macrocycles containing triazole and lactone moieties have been designed and synthesized. The synthesis features an intramolecular nucleophilic substitution reaction for the macrocyclization step. In this article, the effect of some common sulfonate leaving groups is evaluated for macrolactonization. Using tosylate gave good selectivity for monolactonization products with good yields. Fourteen different macrocycles have been synthesized and characterized, of which eleven macrocycles are from cyclization of the C1 to C6 positions of N-acetyl D-glucosamine derivatives and three others from C2 to C6 cyclization of functionalized D-glucosamine derivatives. These novel macrolactones have unique structures and demonstrate interesting anion binding properties, especially for chloride. The macrocycles containing two triazoles form complexes with copper sulfate, and they are effective ligands for copper sulfate mediated azide-alkyne cycloaddition reactions (CuAAC). In addition, several macrocycles show some selectivity for different alkynes.

Lewis-Acid-Catalyzed Direct Nucleophilic Substitution Reaction of Alcohols for the Functionalization of Aromatic Amines

2019 ◽  
Vol 4 (4) ◽  
pp. 1371-1374 ◽  
Author(s):  
Onkar S. Nayal ◽  
Maheshwar S. Thakur ◽  
Rohit Rana ◽  
Rahul Upadhyay ◽  
Sushil K. Maurya
Keyword(s):  
Nucleophilic Substitution ◽  
Lewis Acid ◽  
Aromatic Amines ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Acid Catalyzed
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