scholarly journals Impact of Variation Near MC4R on Whole-body Fat Distribution, Liver Fat, and Weight Loss

Obesity ◽  
2009 ◽  
Vol 17 (10) ◽  
pp. 1942-1945 ◽  
Author(s):  
Axel Haupt ◽  
Claus Thamer ◽  
Martin Heni ◽  
Otto Tschritter ◽  
Jürgen Machann ◽  
...  
Obesity ◽  
2008 ◽  
Vol 16 (8) ◽  
pp. 1969-1972 ◽  
Author(s):  
Axel Haupt ◽  
Claus Thamer ◽  
Jürgen Machann ◽  
Kerstin Kirchhoff ◽  
Norbert Stefan ◽  
...  

2018 ◽  
Vol 7 (12) ◽  
pp. 528 ◽  
Author(s):  
Robinson Ramírez-Vélez ◽  
Mikel Izquierdo ◽  
Jorge Correa-Bautista ◽  
María Correa-Rodríguez ◽  
Jacqueline Schmidt-RioValle ◽  
...  

This study had two main objectives: To examine the association between body fat distribution and non-alcoholic fatty liver disease (NAFLD) and liver fat content, and to determine whether the relationship between NAFLD and regional body fat distribution, with respect to liver fat content in youths with excess adiposity, is independent of cardiorespiratory fitness (CRF) and a healthy diet. Liver fat content (controlled attenuation parameter (CAP)), body fat distribution (body mass index (BMI) z-score, waist circumference, waist-to-height ratio, fat mass/height, body fat percentage, total fat mass, android-to-gynoid fat mass ratio, visceral adipose tissue (VAT), and lean mass index, determined by dual-energy X-ray absorptiometry (DXA)), CRF (20-m shuttle-run test), and healthy diet (adherence to the Mediterranean diet by KIDMED questionnaire) were measured in 126 adolescents (66% girls) aged between 11 and 17 years. Participants were assigned to two groups according to the presence or absence of hepatic steatosis (CAP values ≥225 dB/m or <225 dB/m of liver fat, respectively). Considering the similar total fat values for the two groups (>30% by DXA), youths with NAFLD had higher fat distribution parameters than those without NAFLD, regardless of sex, age, puberty stage, lean mass index, CRF, and healthy diet (p < 0.01). In the non-NAFLD group, the association between hepatic fat and fat distribution parameters presented a similar pattern, although the association was statistically insignificant after adjusting for a potential confounding variable (ps > 0.05), except for the case of VAT. Body fat distribution parameters were higher in youths with NAFLD compared to those without NAFLD. Additionally, body fat distribution showed a significant association with liver fat content as assessed by CAP in youths with NAFLD independent of CRF and adherence to the Mediterranean diet, supporting the notion that upper body fat distribution might play a pivotal role in the development of NAFLD in adolescents. These results may have implications for the clinical management of youths with excess adiposity given the high prevalence of NAFLD in children and young adults.


2011 ◽  
Vol 165 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Henna Cederberg ◽  
Ulla Rajala ◽  
Vesa-Matti Koivisto ◽  
Jari Jokelainen ◽  
Heljä-Marja Surcel ◽  
...  

ObjectiveGhrelin, a gut–brain peptide involved in energy homeostasis, circulates predominantly (>90%) in unacylated form. Previous studies, however, have focused on total and acylated ghrelin, and the role of unacylated ghrelin (UAG) is not well understood. Particularly, the association of UAG with weight loss and changes in body composition in adults remains unclear. We hypothesized that exercise-associated increase in UAG level is associated with weight loss, favorable changes in body composition, and body fat distribution.Design and methodsA prospective study of 552 young men (mean age 19.3 and range 19–28 years) undergoing military service with structured 6-month exercise training program. Exercise performance, body composition, and biochemical measurements were obtained at baseline and follow-up. Association between changes in UAG levels and body composition and body fat distribution were evaluated.ResultsAn increase in UAG level during the exercise intervention was associated with reduced weight, fat mass (FM), fat percentage (fat %), and waist circumference, but not with fat-free mass. Inverse associations of changes in UAG level with changes in waist circumference and fat % were independent of weight at baseline, and changes in weight and exercise performance. Associations of changes in UAG level with waist circumference were significantly stronger than with fat % after the adjustment for confounding variables.ConclusionUAG is associated with changes in body weight and body composition during an intensive long-term exercise intervention in young men. The association of UAG levels with changes in central obesity was stronger than with total FM.


1993 ◽  
Vol 58 (1) ◽  
pp. 29-34 ◽  
Author(s):  
M Zamboni ◽  
F Armellini ◽  
E Turcato ◽  
T Todesco ◽  
L Bissoli ◽  
...  

2001 ◽  
Vol 25 (2) ◽  
pp. 296-298 ◽  
Author(s):  
MC Nguyen ◽  
RB Stewart ◽  
MA Banerji ◽  
DH Gordon ◽  
JG Kral

2005 ◽  
Vol 185 (2) ◽  
pp. 418-423 ◽  
Author(s):  
Darren D. Brennan ◽  
Paul F. Whelan ◽  
Kevin Robinson ◽  
Ovidiu Ghita ◽  
Julie M. O'Brien ◽  
...  

1991 ◽  
Vol 9 (6) ◽  
pp. S441
Author(s):  
Bjorn Fagerberg ◽  
A. Berglund ◽  
Goran Berglund ◽  
Ove K. Andersson

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e022465
Author(s):  
Chen Wei ◽  
Sunyue Ye ◽  
Jessica Ruolin Sheng ◽  
Xiaoguang Ma ◽  
Yuan Ru ◽  
...  

IntroductionPrevious studies have showed association between smoking and central fat distribution. However, the impact of smoking on whole body fat distribution, particularly peripheral fat distribution remains unclear.MethodsNicotine dependence was assessed in a total of 1264 male adults aged 18–80 years using the Fagerström Test for Nicotine Dependence (FTND). Smoking status was categorised as non-smokers, former and current smokers with very low, low/moderate, or high FTND scores. Body fat distribution was determined using the dual energy X-ray absorptiometry and anthropometric measurements. Multivariable linear regression models were applied to examine the adjusted associations between body fat distribution and smoking in all participants, and its association with FTND scores in the current smokers.ResultsGreater waist circumference (WC), waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), trunk fat percentage (%TF), android fat percentage (%AF) and android-to-gynoid fat mass ratio (AOI); but lower legs fat percentage (%LegF), limb fat percentage (%LimbF) and gynoid fat percentage (%GF) were found in current smokers with high FTND scores compared with non-smokers. In current smokers aged 60 years or older, FTND scores had positive associations with WC, WHR, WHtR, %TF, %AF and AOI, and negative associations with %LegF, %LimbF and %GF.ConclusionsNicotine dependence was positively associated with central fat distribution and negatively associated with peripheral fat distribution in Chinese male adults, particularly in those older or heavy smokers, and these associations were independent from body mass index, which might be due to long exposure to smoking.


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