scholarly journals Carotid artery remodelling in relation to body fat distribution, inflammation and sustained weight loss in obesity

2014 ◽  
Vol 275 (5) ◽  
pp. 534-543 ◽  
Author(s):  
D. Kardassis ◽  
M. Schönander ◽  
L. Sjöström ◽  
K. Karason
Obesity ◽  
2008 ◽  
Vol 16 (8) ◽  
pp. 1969-1972 ◽  
Author(s):  
Axel Haupt ◽  
Claus Thamer ◽  
Jürgen Machann ◽  
Kerstin Kirchhoff ◽  
Norbert Stefan ◽  
...  

2011 ◽  
Vol 165 (2) ◽  
pp. 243-248 ◽  
Author(s):  
Henna Cederberg ◽  
Ulla Rajala ◽  
Vesa-Matti Koivisto ◽  
Jari Jokelainen ◽  
Heljä-Marja Surcel ◽  
...  

ObjectiveGhrelin, a gut–brain peptide involved in energy homeostasis, circulates predominantly (>90%) in unacylated form. Previous studies, however, have focused on total and acylated ghrelin, and the role of unacylated ghrelin (UAG) is not well understood. Particularly, the association of UAG with weight loss and changes in body composition in adults remains unclear. We hypothesized that exercise-associated increase in UAG level is associated with weight loss, favorable changes in body composition, and body fat distribution.Design and methodsA prospective study of 552 young men (mean age 19.3 and range 19–28 years) undergoing military service with structured 6-month exercise training program. Exercise performance, body composition, and biochemical measurements were obtained at baseline and follow-up. Association between changes in UAG levels and body composition and body fat distribution were evaluated.ResultsAn increase in UAG level during the exercise intervention was associated with reduced weight, fat mass (FM), fat percentage (fat %), and waist circumference, but not with fat-free mass. Inverse associations of changes in UAG level with changes in waist circumference and fat % were independent of weight at baseline, and changes in weight and exercise performance. Associations of changes in UAG level with waist circumference were significantly stronger than with fat % after the adjustment for confounding variables.ConclusionUAG is associated with changes in body weight and body composition during an intensive long-term exercise intervention in young men. The association of UAG levels with changes in central obesity was stronger than with total FM.


1993 ◽  
Vol 58 (1) ◽  
pp. 29-34 ◽  
Author(s):  
M Zamboni ◽  
F Armellini ◽  
E Turcato ◽  
T Todesco ◽  
L Bissoli ◽  
...  

1991 ◽  
Vol 9 (6) ◽  
pp. S441
Author(s):  
Bjorn Fagerberg ◽  
A. Berglund ◽  
Goran Berglund ◽  
Ove K. Andersson

2019 ◽  
Vol 3 (3) ◽  
Author(s):  
Catherine R Marinac ◽  
Catherine A Suppan ◽  
Edward Giovannucci ◽  
Mingyang Song ◽  
Ane S Kværner ◽  
...  

Abstract Background Although obesity is an established modifiable risk factor for multiple myeloma (MM), several nuanced aspects of its relation to MM remain unelucidated, limiting public health and prevention messages. Methods We analyzed prospective data from the Nurses’ Health Study and Health Professionals Follow-Up Study to examine MM risk associated with 20-year weight patterns in adulthood, body shape trajectory from ages 5 to 60 years, and body fat distribution. For each aforementioned risk factor, we report hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MM from multivariable Cox proportional-hazards models. Results We documented 582 incident MM cases during 4 280 712 person-years of follow-up. Persons who exhibited extreme weight cycling, for example, those with net weight gain and one or more episodes of intentional loss of at least 20 pounds or whose cumulative intentional weight loss exceeded net weight loss with at least one episode of intentional loss of 20 pounds or more had an increased MM risk compared with individuals who maintained their weight (HR = 1.71, 95% CI = 1.05 to 2.80); the association was statistically nonsignificant after adjustment for body mass index. We identified four body shape trajectories: lean-stable, lean-increase, medium-stable, and medium-increase. MM risk was higher in the medium-increase group than in the lean-stable group (HR = 1.62, 95% CI = 1.22 to 2.14). Additionally, MM risk increased with increasing hip circumference (HR per 1-inch increase: 1.03, 95% CI = 1.01 to 1.06) but was not associated with other body fat distribution measures. Conclusions Maintaining a lean and stable weight throughout life may provide the strongest benefit in terms of MM prevention.


1997 ◽  
Vol 39 (1) ◽  
pp. 28-33 ◽  
Author(s):  
KATSUMI TORIGOE ◽  
OSAMU NUMATA ◽  
MASAMITI MATSUNAGA ◽  
YASUKI TANAKA ◽  
CHIHAYA IMAI ◽  
...  

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