scholarly journals New Insights into the Pathogenesis of Insulin Resistance in Humans Using Magnetic Resonance Spectroscopy

Obesity ◽  
2006 ◽  
Vol 14 (2S) ◽  
pp. 34S-40S ◽  
Author(s):  
Kitt Falk Petersen ◽  
Gerald I. Shulman
Keyword(s):  
Insulin Resistance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy

scholarly journals Magnetic resonance spectroscopy analysis of intramyocellular lipid composition in lipodystrophic patients and athletes

2018 ◽  
Author(s):  
David B Savage ◽  
Laura Watson ◽  
Katie Carr ◽  
Claire Adams ◽  
Soren Brage ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Tibialis Anterior ◽  
Saturation Index ◽  
Resonance Spectroscopy ◽  
Intramyocellular Lipid ◽  
Age And Gender ◽  
Insulin Resistant ◽  
And Gender

AbstractContextParadoxically, intramyocellular lipid (IMCL) accumulation has been linked to both insulin-resistant and to insulin-sensitive (athletes) states. The composition of this lipid store is unknown in these states.Design and MethodsWe used a recently validated and potentially widely applicable 1H magnetic resonance spectroscopy method to compare the compositional saturation index (CH2:CH3 ratio) and concentration independent of composition (CH3) of intramyocellular lipid in the soleus and tibialis anterior muscles of 16 female insulin-resistant lipodystrophic patients with that of age- and gender-matched athletes (n=14) and healthy controls (n = 41).Main OutcomeIMCL compositional saturation index (CH2:CH3 ratio).ResultsThe IMCL CH2:CH3 ratio was significantly higher in both muscles of the lipodystrophic patients compared with age- and gender-matched controls but not compared to athletes. IMCL CH2:CH3 was dependent on IMCL concentration in the controls and after adjusting the composition index for quantity (CH2:CH3adj) was able to distinguish patients from athletes. With groups pooled, this CH2:CH3adj marker had the strongest relation to insulin resistance (HOMA-IR) compared to other measures of lipid concentration and composition, especially in the soleus muscle. Contrary to the ‘athlete’s paradox’, IMCL in athletes was similar in tibialis anterior (p>0.05) and significantly lower in the soleus (p < 0.004) compared to both controls and patients.ConclusionsThe IMCL saturation index adjusted for quantity, which likely reflects accumulation of saturated IMCL, is more closely associated with insulin resistance than concentration alone.

Unraveling the Cellular Mechanism of Insulin Resistance in Humans: New Insights from Magnetic Resonance Spectroscopy

Physiology ◽  
2004 ◽  
Vol 19 (4) ◽  
pp. 183-190 ◽  
Author(s):  
Gerald I. Shulman
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Underlying Mechanism ◽  
Cellular Mechanism ◽  
Resonance Spectroscopy ◽  
Recent Advances

Insulin resistance plays a major role in the pathogenesis of type 2 diabetes, yet despite much research the underlying mechanism responsible for it is poorly understood. In this review, some recent advances in the understanding of insulin resistance in humans that have been made by using magnetic resonance spectroscopy are discussed.

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