scholarly journals Insulin Resistance Is Associated With Reduced Mitochondrial Oxidative Capacity Measured by31P-Magnetic Resonance Spectroscopy in Participants Without Diabetes From the Baltimore Longitudinal Study of Aging

Diabetes ◽  
2016 ◽  
Vol 66 (1) ◽  
pp. 170-176 ◽  
Author(s):  
Elisa Fabbri ◽  
Chee W. Chia ◽  
Richard G. Spencer ◽  
Kenneth W. Fishbein ◽  
David A. Reiter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Longitudinal Study ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Oxidative Capacity ◽  
Resonance Spectroscopy ◽  
Mitochondrial Oxidative Capacity ◽  
Baltimore Longitudinal Study

scholarly journals Greater Skeletal Muscle Oxidative Capacity Is Associated With Higher Resting Metabolic Rate: Results From the Baltimore Longitudinal Study of Aging

2020 ◽  
Vol 75 (12) ◽  
pp. 2262-2268 ◽  
Author(s):  
Marta Zampino ◽  
Richard D Semba ◽  
Fatemeh Adelnia ◽  
Richard G Spencer ◽  
Kenneth W Fishbein ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Longitudinal Study ◽  
Metabolic Rate ◽  
Resting Metabolic Rate ◽  
Oxidative Capacity ◽  
Muscle Quality ◽  
Resonance Spectroscopy ◽  
Linear Regression Models ◽  
Mitochondrial Oxidative Capacity ◽  
Baltimore Longitudinal Study

Abstract Resting metabolic rate (RMR) tends to decline with aging. The age-trajectory of decline in RMR is similar to changes that occur in muscle mass, muscle strength, and fitness, but while the decline in these phenotypes has been related to changes of mitochondrial function and oxidative capacity, whether lower RMR is associated with poorer mitochondrial oxidative capacity is unknown. In 619 participants of the Baltimore Longitudinal Study of Aging, we analyzed the cross-sectional association between RMR (kcal/day), assessed by indirect calorimetry, and skeletal muscle maximal oxidative phosphorylation capacity, assessed as postexercise phosphocreatine recovery time constant (τ PCr), by phosphorous magnetic resonance spectroscopy. Linear regression models were used to evaluate the relationship between τ PCr and RMR, adjusting for potential confounders. Independent of age, sex, lean body mass, muscle density, and fat mass, higher RMR was significantly associated with shorter τ PCr, indicating greater mitochondrial oxidative capacity. Higher RMR is associated with a higher mitochondrial oxidative capacity in skeletal muscle. This association may reflect a relationship between better muscle quality and greater mitochondrial health.

scholarly journals Cardiovascular Health and Mitochondrial Function: Testing an Association

2020 ◽  
Author(s):  
Marta Zampino ◽  
Richard G Spencer ◽  
Kenneth W Fishbein ◽  
Eleanor M Simonsick ◽  
Luigi Ferrucci
Keyword(s):  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Energy Production ◽  
Cardiovascular Health ◽  
Oxidative Capacity ◽  
Community Dwelling ◽  
Resonance Spectroscopy ◽  
Phosphorus Magnetic Resonance Spectroscopy ◽  
Mitochondrial Oxidative Capacity ◽  
History Of

Abstract Background Although mitochondrial dysfunction appears to be a contributing factor in the pathogenesis of cardiovascular and metabolic diseases, empirical data on this association are still lacking. This study evaluated whether mitochondrial oxidative capacity, as assessed by phosphorus magnetic resonance spectroscopy, was associated with cardiovascular risk, as estimated by the Framingham Risk Score (FRS), and with a clinical history of cardiovascular disease (CVD), in community-dwelling adults. Method A total of 616 subjects from the Baltimore Longitudinal Study of Aging (mean age 66 years) underwent a comprehensive clinical evaluation. Mitochondrial oxidative capacity in skeletal muscle was assessed as post-exercise phosphocreatine recovery time constant by phosphorus magnetic resonance spectroscopy. Multivariate regression models were employed to determine the cross-sectional association of mitochondrial oxidative capacity with FRS and history of CVD. Results Decreased mitochondrial oxidative capacity was strongly associated with higher FRS independent of age, body composition, and physical activity. Lower oxidative capacity was also associated with a history of positive of CVD and higher number of CVD events. Conclusions We speculate that the observed association could reflect the effect of an excessive production of oxidative species by dysfunctional mitochondria. Furthermore, decreased energy production could hamper the functionality of heart and vessels. In turn, a malfunctioning cardiovascular apparatus could fail to deliver the oxygen necessary for optimal mitochondrial energy production, therefore creating a vicious cycle. Longitudinal studies are necessary to ascertain the directionality of the association and the eventual presence of common pathogenetic roots. In conclusion, mitochondria could represent an important target for intervention in cardiovascular health.

A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers

2015 ◽  
Vol 30 (3) ◽  
pp. 393-401 ◽  
Author(s):  
Aaron Sturrock ◽  
Corree Laule ◽  
Katy Wyper ◽  
Ruth A. Milner ◽  
Joji Decolongon ◽  
...  
Keyword(s):  
Longitudinal Study ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Resonance Spectroscopy ◽  
Disease Biomarkers
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