Effect of early hemofiltration on pro- and anti-inflammatory responses and multiple organ failure in severe acute pancreatitis

2004 ◽  
Vol 24 (5) ◽  
pp. 456-459 ◽  
Author(s):  
Yang Zhiyong ◽  
Wang Chunyou ◽  
Tao Jing ◽  
Xiong Jiongxin ◽  
Wan Chidan ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Severe Acute Pancreatitis ◽  
Inflammatory Responses ◽  
Multiple Organ ◽  
Anti Inflammatory

Discrepancy Between the Extent of Pancreatic Necrosis and Multiple Organ Failure Score in Severe Acute Pancreatitis

2009 ◽  
Vol 33 (11) ◽  
pp. 2427-2432 ◽  
Author(s):  
Damian J. Mole ◽  
Katie L. McClymont ◽  
Sarah Lau ◽  
Rosamund Mills ◽  
Christopher Stamp-Vincent ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Severe Acute Pancreatitis ◽  
Pancreatic Necrosis ◽  
Multiple Organ ◽  
Organ Failure Score

Successful Management of Severe Acute Pancreatitis With Multiple Organ Failure

Pancreas ◽  
2004 ◽  
Vol 28 (2) ◽  
pp. 211-213 ◽  
Author(s):  
Toru Mizuguchi ◽  
Mitsuhiro Mukaiya ◽  
Hitoshi Imaizumi ◽  
Yasutoshi Kimura ◽  
Yoshiki Masuda ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Severe Acute Pancreatitis ◽  
Multiple Organ ◽  
Successful Management

scholarly journals A systematic review on the timing of artificial nutrition in acute pancreatitis

2008 ◽  
Vol 101 (6) ◽  
pp. 787-793 ◽  
Author(s):  
Maxim S. Petrov ◽  
Romana D. Pylypchuk ◽  
Antonina F. Uchugina
Keyword(s):  
Acute Pancreatitis ◽  
Enteral Nutrition ◽  
Parenteral Nutrition ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Infectious Complications ◽  
Multiple Organ ◽  
Artificial Nutrition ◽  
Controlled Trials ◽  
Randomised Controlled

Artificial nutrition is an inherent part of management in acute pancreatitis. However, there is no consensus regarding the optimal time of the commencement of feeding in these patients. Our aim was to compare the effect of enteral v. parenteral nutrition with regard to the time points when they were administered in the randomised controlled trials. The search was undertaken in the Cochrane Central Register of Controlled Trials, MEDLINE and Science Citation Index as well as in the proceedings of major gastroenterology meetings. The summary estimate of the effect associated with artificial nutrition was calculated using a random-effects model and presented as a risk ratio (RR) and 95 % CI. A total of eleven randomised controlled trials were included. When started within 48 h of admission, enteral nutrition, in comparison with parenteral nutrition, resulted in a statistically significant reduction in the risks of multiple organ failure (RR 0·44; 95 % CI 0·23, 0·84), pancreatic infectious complications (RR 0·46; 95 % CI 0·27, 0·77) and mortality (RR 0·46; 95 % CI 0·20, 0·99). After 48 h of admission, enteral nutrition, in comparison with parenteral nutrition, did not result in a statistically significant reduction in the risks of multiple organ failure (RR 0·73; 95 % CI 0·33, 1·63), pancreatic infectious complications (RR 0·31; 95 % CI 0·07, 1·34) and mortality (RR 0·67; 95 % CI 0·22, 2·10). Enteral nutrition is more effective than parenteral nutrition in reducing the risk of multiple organ failure, pancreatic infectious complications and mortality in patients with acute pancreatitis. The magnitude of these benefits may depend on the timing of the commencement of nutrition.

scholarly journals HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Runkuan Yang ◽  
Xiaoping Zou ◽  
Jyrki Tenhunen ◽  
Tor Inge Tønnessen
Keyword(s):  
Liver Failure ◽  
Acute Liver Failure ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Systemic Inflammation ◽  
Cell Injury ◽  
Inflammatory Responses ◽  
Multiple Organ ◽  
Hepatocyte Regeneration ◽  
Extracellular Histones

Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes. ALF occurs when the extent of hepatocyte death exceeds the hepatic regenerative capacity. ALF has a high mortality that is associated with multiple organ failure (MOF) and sepsis; however, the underlying mechanisms are still not clear. Emerging evidence shows that ALF patients/animals have high concentrations of circulating HMGB1, which can contribute to multiple organ injuries and mediate gut bacterial translocation (BT). BT triggers/induces systemic inflammatory responses syndrome (SIRS), which can lead to MOF in ALF. Blockade of HMGB1 significantly decreases BT and improves hepatocyte regeneration in experimental acute fatal liver injury. Therefore, HMGB1 seems to be an important factor that links BT and systemic inflammation in ALF. ALF patients/animals also have high levels of circulating histones, which might be the major mediators of systemic inflammation in patients with ALF. Extracellular histones kill endothelial cells and elicit immunostimulatory effect to induce multiple organ injuries. Neutralization of histones can attenuate acute liver, lung, and brain injuries. In conclusion, HMGB1 and histones play a significant role in inducing systemic inflammation and MOF in ALF.

scholarly journals Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis

2016 ◽  
Vol 22 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Damian J Mole ◽  
Scott P Webster ◽  
Iain Uings ◽  
Xiaozhong Zheng ◽  
Margaret Binnie ◽  
...  
Keyword(s):  
Acute Pancreatitis ◽  
Multiple Organ Failure ◽  
Organ Failure ◽  
Multiple Organ ◽  
Rodent Models
Sign in / Sign up

Export Citation Format

Share Document