Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

2009 ◽  
Vol 41 (2) ◽  
pp. 157-159 ◽  
Author(s):  
David Meyre ◽  
Jérôme Delplanque ◽  
Jean-Claude Chèvre ◽  
Cécile Lecoeur ◽  
Stéphane Lobbens ◽  
...  
Keyword(s):  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Adult Obesity ◽  
Genome Wide ◽  
European Populations

scholarly journals Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lawrence Shih-Hsin Wu ◽  
Ming-Chyi Huang ◽  
Cathy Shen-Jang Fann ◽  
Hsien-Yuan Lane ◽  
Chian-Jue Kuo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genetic Locus ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Chinese Descent

AbstractThe search for susceptibility genes underlying the heterogeneous bipolar disorder has been inconclusive, often with irreproducible results. There is a hope that narrowing the phenotypes will increase the power of genetic analysis. Early-onset bipolar disorder is thought to be a genetically homogeneous subtype with greater symptom severity. We conducted a genome-wide association study (GWAS) for this subtype in bipolar I (BPI) disorder. Study participants included 1779 patients of Han Chinese descent with BPI disorder recruited by the Taiwan Bipolar Consortium. We conducted phenotype assessment using the Chinese version of the Schedules for Clinical Assessment in Neuropsychiatry and prepared a life chart with graphic depiction of lifetime clinical course for each of the BPI patient recruited. The assessment of onset age was based on this life chart with early onset defined as ≤20 years of age. We performed GWAS in a discovery group of 516 early-onset and 790 non-early-onset BPI patients, followed by a replication study in an independent group of 153 early-onset and 320 non-early-onset BPI patients and a meta-analysis with these two groups. The SNP rs11127876, located in the intron of CADM2, showed association with early-onset BPI in the discovery cohort (P = 7.04 × 10−8) and in the test of replication (P = 0.0354). After meta-analysis, this SNP was demonstrated to be a new genetic locus in CADM2 gene associated with early-onset BPI disorder (P = 5.19 × 10−8).

scholarly journals Genome‐wide association study identifies an early onset pancreatic cancer risk locus

2020 ◽  
Vol 147 (8) ◽  
pp. 2065-2074 ◽  
Author(s):  
Daniele Campa ◽  
Manuel Gentiluomo ◽  
Ofure Obazee ◽  
Alba Ballerini ◽  
Ludmila Vodickova ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Pancreatic Cancer Risk ◽  
Genome Wide ◽  
Risk Locus

scholarly journals Genome-Wide Association Study of Metamizole-Induced Agranulocytosis in European Populations

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1275
Author(s):  
Anca Cismaru ◽  
Deborah Rudin ◽  
Luisa Ibañez ◽  
Evangelia Liakoni ◽  
Nicolas Bonadies ◽  
...  
Keyword(s):  
Association Study ◽  
Genome Wide Association Study ◽  
Meta Analysis ◽  
Underlying Mechanism ◽  
Chromosome 9 ◽  
Genome Wide Association ◽  
Association Analyses ◽  
Genome Wide ◽  
Risk Patients ◽  
European Populations

Agranulocytosis is a rare yet severe idiosyncratic adverse drug reaction to metamizole, an analgesic widely used in countries such as Switzerland and Germany. Notably, an underlying mechanism has not yet been fully elucidated and no predictive factors are known to identify at-risk patients. With the aim to identify genetic susceptibility variants to metamizole-induced agranulocytosis (MIA) and neutropenia (MIN), we conducted a retrospective multi-center collaboration including cases and controls from three European populations. Association analyses were performed using genome-wide genotyping data from a Swiss cohort (45 cases, 191 controls) followed by replication in two independent European cohorts (41 cases, 273 controls) and a joint discovery meta-analysis. No genome-wide significant associations (p < 1 × 10−7) were observed in the Swiss cohort or in the joint meta-analysis, and no candidate genes suggesting an immune-mediated mechanism were identified. In the joint meta-analysis of MIA cases across all cohorts, two candidate loci on chromosome 9 were identified, rs55898176 (OR = 4.01, 95%CI: 2.41–6.68, p = 1.01 × 10−7) and rs4427239 (OR = 5.47, 95%CI: 2.81–10.65, p = 5.75 × 10−7), of which the latter is located in the SVEP1 gene previously implicated in hematopoiesis. This first genome-wide association study for MIA identified suggestive associations with biological plausibility that may be used as a stepping-stone for post-GWAS analyses to gain further insight into the mechanism underlying MIA.

scholarly journals Genome-wide association study of recurrent early-onset major depressive disorder

2010 ◽  
Vol 16 (2) ◽  
pp. 193-201 ◽  
Author(s):  
J Shi ◽  
J B Potash ◽  
J A Knowles ◽  
M M Weissman ◽  
W Coryell ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Major Depressive ◽  
Genome Wide
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