A genome wide association study suggests the association of muskelin with early onset bipolar disorder: Implications for a GABAergic epileptogenic neurogenesis model

2017 ◽  
Vol 208 ◽  
pp. 120-129 ◽  
Author(s):  
Malik Nassan ◽  
Qingqin Li ◽  
Paul E. Croarkin ◽  
Wenan Chen ◽  
Colin L. Colby ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lawrence Shih-Hsin Wu ◽  
Ming-Chyi Huang ◽  
Cathy Shen-Jang Fann ◽  
Hsien-Yuan Lane ◽  
Chian-Jue Kuo ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genetic Locus ◽  
Meta Analysis ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Chinese Descent

AbstractThe search for susceptibility genes underlying the heterogeneous bipolar disorder has been inconclusive, often with irreproducible results. There is a hope that narrowing the phenotypes will increase the power of genetic analysis. Early-onset bipolar disorder is thought to be a genetically homogeneous subtype with greater symptom severity. We conducted a genome-wide association study (GWAS) for this subtype in bipolar I (BPI) disorder. Study participants included 1779 patients of Han Chinese descent with BPI disorder recruited by the Taiwan Bipolar Consortium. We conducted phenotype assessment using the Chinese version of the Schedules for Clinical Assessment in Neuropsychiatry and prepared a life chart with graphic depiction of lifetime clinical course for each of the BPI patient recruited. The assessment of onset age was based on this life chart with early onset defined as ≤20 years of age. We performed GWAS in a discovery group of 516 early-onset and 790 non-early-onset BPI patients, followed by a replication study in an independent group of 153 early-onset and 320 non-early-onset BPI patients and a meta-analysis with these two groups. The SNP rs11127876, located in the intron of CADM2, showed association with early-onset BPI in the discovery cohort (P = 7.04 × 10−8) and in the test of replication (P = 0.0354). After meta-analysis, this SNP was demonstrated to be a new genetic locus in CADM2 gene associated with early-onset BPI disorder (P = 5.19 × 10−8).

scholarly journals Mood‐Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome‐Wide Association Study

2020 ◽  
Vol 108 (6) ◽  
pp. 1233-1242
Author(s):  
Ada Man‐Choi Ho ◽  
Brandon J. Coombes ◽  
Thanh Thanh L. Nguyen ◽  
Duan Liu ◽  
Susan L. McElroy ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Association Study ◽  
Treatment Response ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Antiepileptic Treatment ◽  
Genome Wide ◽  
A Genome

scholarly journals Bipolar disorder with binge eating behavior: a genome-wide association study implicates PRR5-ARHGAP8

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Susan L. McElroy ◽  
Stacey J. Winham ◽  
Alfredo B. Cuellar-Barboza ◽  
Colin L. Colby ◽  
Ada Man-Choi Ho ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Binge Eating ◽  
Association Study ◽  
Eating Behavior ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome
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