scholarly journals Genome‐wide association study identifies an early onset pancreatic cancer risk locus

2020 ◽  
Vol 147 (8) ◽  
pp. 2065-2074 ◽  
Author(s):  
Daniele Campa ◽  
Manuel Gentiluomo ◽  
Ofure Obazee ◽  
Alba Ballerini ◽  
Ludmila Vodickova ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Pancreatic Cancer Risk ◽  
Genome Wide ◽  
Risk Locus

scholarly journals A novel colorectal cancer risk locus at 4q32.2 identified from an international genome-wide association study

2014 ◽  
Vol 35 (11) ◽  
pp. 2512-2519 ◽  
Author(s):  
Stephanie L. Schmit ◽  
Fredrick R. Schumacher ◽  
Christopher K. Edlund ◽  
David V. Conti ◽  
Leon Raskin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Colorectal Cancer Risk ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Risk Locus

scholarly journals A Transcriptome-Wide Association Study Identifies Novel Candidate Susceptibility Genes for Pancreatic Cancer

2020 ◽  
Vol 112 (10) ◽  
pp. 1003-1012 ◽  
Author(s):  
Jun Zhong ◽  
Ashley Jermusyk ◽  
Lang Wu ◽  
Jason W Hoskins ◽  
Irene Collins ◽  
...  
Keyword(s):  
Gene Expression ◽  
Pancreatic Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Association Studies ◽  
Tissue Expression ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Pancreatic Cancer Risk ◽  
Genome Wide

Abstract Background Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. Methods To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association study in Europeans using three approaches: FUSION, MetaXcan, and Summary-MulTiXcan. We integrated genome-wide association studies summary statistics from 9040 pancreatic cancer cases and 12 496 controls, with gene expression prediction models built using transcriptome data from histologically normal pancreatic tissue samples (NCI Laboratory of Translational Genomics [n = 95] and Genotype-Tissue Expression v7 [n = 174] datasets) and data from 48 different tissues (Genotype-Tissue Expression v7, n = 74–421 samples). Results We identified 25 genes whose genetically predicted expression was statistically significantly associated with pancreatic cancer risk (false discovery rate < .05), including 14 candidate genes at 11 novel loci (1p36.12: CELA3B; 9q31.1: SMC2, SMC2-AS1; 10q23.31: RP11-80H5.9; 12q13.13: SMUG1; 14q32.33: BTBD6; 15q23: HEXA; 15q26.1: RCCD1; 17q12: PNMT, CDK12, PGAP3; 17q22: SUPT4H1; 18q11.22: RP11-888D10.3; and 19p13.11: PGPEP1) and 11 at six known risk loci (5p15.33: TERT, CLPTM1L, ZDHHC11B; 7p14.1: INHBA; 9q34.2: ABO; 13q12.2: PDX1; 13q22.1: KLF5; and 16q23.1: WDR59, CFDP1, BCAR1, TMEM170A). The association for 12 of these genes (CELA3B, SMC2, and PNMT at novel risk loci and TERT, CLPTM1L, INHBA, ABO, PDX1, KLF5, WDR59, CFDP1, and BCAR1 at known loci) remained statistically significant after Bonferroni correction. Conclusions By integrating gene expression and genotype data, we identified novel pancreatic cancer risk loci and candidate functional genes that warrant further investigation.

scholarly journals Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33

2008 ◽  
Vol 105 (11) ◽  
pp. 4340-4345 ◽  
Author(s):  
B. Gold ◽  
T. Kirchhoff ◽  
S. Stefanov ◽  
J. Lautenberger ◽  
A. Viale ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
Risk Locus

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

2009 ◽  
Vol 41 (2) ◽  
pp. 157-159 ◽  
Author(s):  
David Meyre ◽  
Jérôme Delplanque ◽  
Jean-Claude Chèvre ◽  
Cécile Lecoeur ◽  
Stéphane Lobbens ◽  
...  
Keyword(s):  
Association Study ◽  
Early Onset ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Adult Obesity ◽  
Genome Wide ◽  
European Populations

scholarly journals Genome-wide association study using diversity outcross mice identified candidate genes of pancreatic cancer

Genomics ◽  
2019 ◽  
Vol 111 (6) ◽  
pp. 1882-1888 ◽  
Author(s):  
Chuanjia Yang ◽  
Yan Wang ◽  
Weixue Xu ◽  
Zhen Liu ◽  
Siqi Zhou ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Association Study ◽  
Candidate Genes ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

scholarly journals Multi-trait genome-wide association study identifies novel endometrial cancer risk loci that are associated with obesity or female testosterone levels

2021 ◽  
Author(s):  
Xuemin Wang ◽  
Pik Fang Kho ◽  
Dhanya Ramachandran ◽  
Cemsel Bafligil ◽  
Frederic Amant ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endometrial Cancer ◽  
Cancer Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Cancer Susceptibility ◽  
Genome Wide Association ◽  
Endometrial Cancer Risk ◽  
Cancer Risk Factors ◽  
Genome Wide

We have performed genetic correlation and Mendelian randomization analyses using publicly available genome-wide association study (GWAS) data to identify endometrial cancer risk factors. These and previously established risk factors of endometrial cancer were then included in a multi-trait Bayesian GWAS analysis to detect endometrial cancer susceptibility variants, identifying three novel loci (7q22.1, 8q24.3 and 16q12.2); two of which were replicated in an independent endometrial cancer GWAS dataset. These loci are hypothesized to affect endometrial cancer risk through altered sex-hormone levels or through effects on obesity. Consistent with this hypothesis, several genes with established roles in these pathways (CYP11B1, CYP3A7, IRX3 and IRX5) were prioritized as candidate endometrial cancer risk genes by interrogation of quantitative trait loci data and chromatin capture assays in endometrial cell lines. The findings of this study identify additional opportunities for hormone treatment and further support weight loss to reduce the risk of developing endometrial cancer.

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