scholarly journals Dynamic Changes in Vascular Permeability, Cerebral Blood Volume, Vascular Density, and Size after Transient Focal Cerebral Ischemia in Rats: Evaluation with Contrast-Enhanced Magnetic Resonance Imaging

2008 ◽  
Vol 28 (8) ◽  
pp. 1491-1501 ◽  
Author(s):  
Chien-Yuan Lin ◽  
Chen Chang ◽  
Wai-Mui Cheung ◽  
Ming-Huang Lin ◽  
Jean-Ju Chen ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Focal Cerebral Ischemia ◽  
Late Phase ◽  
Vascular Density ◽  
Outer Cortex ◽  
Vessel Size ◽  
Small Vessels ◽  
Collateral Vessels

Postischemic cerebral blood flow and blood volume changes have been associated with angiogenesis; nevertheless, the spatiotemporal changes in vascular permeability, vascular density, and vessel size have not been investigated. Here we report a prolonged increase in vascular permeability from day 3 to day 21 after ischemia, in particular in the reperfused outer cortical layers and leptomeninges. Increased cerebral blood volume (CBV) was observed from day 3 to day 14, whereas increased blood volume in small vessels, primarily capillaries, was noticed from day 7 to day 14 in the reperfused cortex. An initial decrease in vascular density and a reciprocal increase in vessel size were observed within the reperfused cortex at days 1 and 3 after ischemia. Immunohistological analysis confirmed a similar decrease in microvessel density and an increase in vessel size in vessels with a diameter greater than 30 μm. These large-sized vessels exhibited intense basic fibroblast growth factor and endothelial nitric oxide synthase immunoreactivity, suggesting the growth of collateral vessels. By contrast, a late increase in vascular density was noticed in the reperfused outer cortex at days 14 and 21 after ischemia. Together, these findings suggest that the early phase of CBV increase is likely because of the improvement in collateral circulation, whereas the late phase of CBV increase is attributed to the surge of angiogenesis.

scholarly journals Perfusion computed tomography of intracranial meningiomas: In vivo correlation of cerebral blood volume and vascular permeability

2015 ◽  
Vol 28 (3) ◽  
pp. 303-309 ◽  
Author(s):  
Francesca Granata ◽  
Rosa Morabito ◽  
Concetta Alafaci ◽  
Valeria Barresi ◽  
Francesco Tomasello ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Vascular Permeability ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Perfusion Computed Tomography ◽  
Intracranial Meningiomas

scholarly journals Sequential Assessment of Regional Cerebral Blood Flow, Regional Cerebral Blood Volume, and Blood—Brain Barrier in Focal Cerebral Ischemia: A Case Report

1986 ◽  
Vol 6 (3) ◽  
pp. 379-384 ◽  
Author(s):  
V. Di Piero ◽  
D. Perani ◽  
A. Savi ◽  
P. Gerundini ◽  
G. L. Lenzi ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Blood Brain Barrier ◽  
Computerized Tomography ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Focal Cerebral Ischemia ◽  
Brain Barrier ◽  
Regional Cerebral Blood ◽  
Blood Brain ◽  
Regional Cerebral Blood Volume

Regional CBF (rCBF) and regional cerebral blood volume (rCBV) were evaluated by N,N,N'-trimethyl- N'-(2)-hydroxy-3-methyl-5-[123I]iodobenzyl-1,3-propanediamine-2 HCl- and 99mTC-labeled red blood cells, respectively, and single-photon emission computerized tomography (SPECT) in a patient with focal cerebral ischemia. Sequential transmission computerized tomography (TCT) and SPECT functional data were compared with clinical findings to monitor the pathophysiological events occurring in stroke. A lack of correlation between rCBF–rCBV distributions and blood–brain barrier (BBB) breakdown was found in the acute phase. In the face of more prolonged alteration of BBB, as seen by TCT enhancement, a rapid evolution of transient phenomena such as luxury perfusion was shown by SPECT studies. Follow-up of the patient demonstrated a correlation between the neurological recovery and a parallel relative improvement of the cerebral perfusion.

scholarly journals Molecular differences between cerebral blood volume and vessel size in glioblastoma multiforme

Oncotarget ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 11083-11093 ◽  
Author(s):  
Dieter Henrik Heiland ◽  
Theo Demerath ◽  
Elias Kellner ◽  
Valerij G. Kiselev ◽  
Dietmar Pfeifer ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vessel Size

scholarly journals Dynamic MRI Using Iron Oxide Nanoparticles to Assess Early Vascular Effects of Antiangiogenic versus Corticosteroid Treatment in a Glioma Model

2009 ◽  
Vol 29 (4) ◽  
pp. 853-860 ◽  
Author(s):  
Csanad G Varallyay ◽  
Leslie L Muldoon ◽  
Seymur Gahramanov ◽  
Yingjen J Wu ◽  
James A Goodman ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Vascular Permeability ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Antiangiogenic Therapy ◽  
Perfusion Mri ◽  
High Dose ◽  
Vascular Effects ◽  
Enhanced Mri ◽  
Contrast Enhanced

The vascular effects of antiangiogenic treatment may pose problems for evaluating brain tumor response based on contrast-enhanced magnetic resonance imaging (MRI). We used serial dynamic contrast-enhanced MRI at 12 T to assess vascular responses to antiangiogenic versus steroid therapy. Athymic rats with intracerebral U87MG human glioma ( n = 17) underwent susceptibility-weighted perfusion MRI with ferumoxytol, a solely intravascular ultrasmall superparamagnetic iron oxide (USPIO) nanoparticle, followed by T1-weighted dynamic gadodiamide-enhanced MRI to measure vascular permeability. Rats were imaged before and after 24, 48, and 72 h of treatment with the antiangiogenic agent bevacizumab or the corticosteroid dexamethasone. Contrast agent extravasation was seen rapidly after gadodiamide, but not with ferumoxytol administration. Bevacizumab significantly decreased the blood volume and decreased permeability in tumors as determined by increased time-to-peak enhancement. A single dose of 45 mg/kg bevacizumab resulted in changes analogous to dexamethasone given in an extremely high dose (12 mg/kg per day), and was significantly more effective than dexamethasone at 2 mg/kg per day. We conclude that dynamic perfusion MRI measurements with ferumoxytol USPIO to assess cerebral blood volume, along with dynamic gadodiamide-enhanced MR to assess vascular permeability, hold promise in more accurately detecting therapeutic responses to antiangiogenic therapy.

scholarly journals Measurements of BOLD/CBV Ratio Show Altered fMRI Hemodynamics during Stroke Recovery in Rats

2005 ◽  
Vol 25 (7) ◽  
pp. 820-829 ◽  
Author(s):  
Young R Kim ◽  
In J Huang ◽  
Seong-Ryong Lee ◽  
Emiri Tejima ◽  
Joseph B Mandeville ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Somatosensory Cortex ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Focal Cerebral Ischemia ◽  
Stroke Recovery ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging

Brain responses to external stimuli after permanent and transient ischemic insults have been documented using cerebral blood volume weighted (CBVw) functional magnetic resonance imaging (fMRI) in correlation with tissue damage and neurological recovery. Here, we extend our previous studies of stroke recovery in rat models of focal cerebral ischemia by comparing blood oxygen level-dependent (BOLD) and cerebral blood volume (CBV) changes. Responses to forepaw stimulation were measured in normal rats ( n = 5) and stroke rats subjected to 2 h of middle cerebral artery occlusion ( n = 6). Functional magnetic resonance imaging was performed 2 weeks after stroke to evaluate the recovery process. After stroke, animals showed variable degrees of fMRI activation in ipsilesional cortex, the extent of which did not correlate with structural damages as measured using apparent diffusion coefficient, fractional anisotropy, blood volume, and vessel size index. While the contralesional cortex showed good overlap between BOLD and CBV-activated regions, the ipsilesional cortex showed low covariance between significantly activated voxels by BOLD and CBVw techniques. In particular, the relative activation during contralateral stimuli in the ipsilesional somatosensory cortex was significantly higher for CBVw responses than BOLD, which might be due to stroke-related alterations in fMRI hemodynamic coupling. Aberrant subcortical activations were also observed. When unaffected forelimbs were stimulated, strong bilateral responses were observed. However, little thalamic responses accompanied stimulation of affected forelimbs despite significant activation in the ipsilesional somatosensory cortex. These results suggest that stroke affects not only local hemodynamics and coupling but also other factors including neural connectivity.

Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma

2004 ◽  
Vol 22 (5) ◽  
pp. 599-606 ◽  
Author(s):  
Meng Law ◽  
Daniel E. Meltzer ◽  
Stephan G. Wetzel ◽  
Stanley Yang ◽  
Edmond A. Knopp ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Vascular Permeability ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Simultaneous Measurements
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