scholarly journals Comparison of the Effect of Vessel Size Imaging and Cerebral Blood Volume Derived from Perfusion MR Imaging on Glioma Grading

2015 ◽  
Vol 37 (1) ◽  
pp. 51-57 ◽  
Author(s):  
H.-Y. Kang ◽  
H.-L. Xiao ◽  
J.-H. Chen ◽  
Y. Tan ◽  
X. Chen ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vessel Size ◽  
Glioma Grading ◽  
Perfusion Mr ◽  
Perfusion Mr Imaging

scholarly journals Accuracy of tumor perfusion assessment in Rat C6 gliomas model with USPIO

Open Medicine ◽  
2019 ◽  
Vol 14 (1) ◽  
pp. 778-784
Author(s):  
Xiang-Rong Yu ◽  
Bo-Ling Cao ◽  
Wei Li ◽  
Ye Tian ◽  
Zhong-Li Du
Keyword(s):  
Mr Imaging ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Tumor Vasculature ◽  
C6 Glioma Cells ◽  
Mr Perfusion ◽  
Mean Values ◽  
Perfusion Mr ◽  
Perfusion Assessment ◽  
Perfusion Mr Imaging

AbstractDetailed characterization of the permeability and vascular volume of brain tumor vasculature can provide essential insights into tumor physiology. In this study, we evaluated the consistency of measurements in tumor blood volume and examined the feasibility of using ultrasmall superparamagnetic iron oxide (USPIO) versus gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA) as contrast agents for MR perfusion imaging of brain gliomas in C6 Rats. Eighteen rats were intracerebrally implanted with C6 glioma cells, randomly divided into two groups and examined by 3.0T perfusion MR imaging with Gd-DTPA and USPIO. Tumor relative cerebral blood volume (rCBV) and relative maximum signal reduction ratio (rSRRmax) were created based on analysis of MR perfusion images. The mean values for rCBV were 2.09 and 1.57 in the USPIO and the Gd-DTPA groups, respectively, and rSRRmax values were 1.92 and 1.02 in the USPIO and the Gd-DTPA groups, respectively, showing signifi cant differences in both rCBV and rSRRmax between the USPIO and the Gd-DTPA groups (P < 0.05). The results showed that early vascular leakage occurred with gadolinium rather than USPIO in perfusion assessment, revealing that USPIO was useful in perfusion MR imaging for the assessment of tumor vasculature.

scholarly journals Magnetic Resonance Imaging with Diffusion and Perfusion in Assessment of Patients with Cerebral Infarction

2021 ◽  
pp. 49-61
Author(s):  
Mervat Samy El-Mestekawy ◽  
Manal Fathy Hamisa ◽  
Ahmed Mohamed El-Shamy ◽  
Samah Ahmed Radwan
Keyword(s):  
Mr Imaging ◽  
Cerebral Infarction ◽  
Cerebral Blood Volume ◽  
Tissue Perfusion ◽  
High Signal ◽  
Significant Difference ◽  
Perfusion Mr ◽  
Reversible Ischemia ◽  
Perfusion Mr Imaging

Background: Diffusion-weighted MR imaging is most useful for detecting irreversibly infarcted tissue, perfusion-weighted imaging may be used to identify areas of reversible ischemia as well. This work highlights the role of MR imaging in acute ischemic infarction evaluation, with particular emphasis on the importance of diffusion and perfusion MR imaging for evaluating the penumbra. Methods: This prospective study was conducted on 30 patients who were suspected to have a cerebral infarction. All patients underwent functional MRI. Results: 25 patients (83.3%) were isointense in T1 and only 5 patients (16.6%) were low intense, in T2 there was 25 patients (83.3%) were high intense and only 5 patients (16.6%) were isointense .in FLAIR there was 24 patients (80%) were high intense and only 6 patients (20%) were isointense. In DW1 all the cases show high signal also in ADC all the cases show low signal. As regards to Ischemic area: the mean rCBV (relative cerebral blood volume) in the core was 0.33±0.30 cc while in the peripheral area was 1.24±1.35 cc. There was a highly significant difference between CT and MRI in diagnosis of acute stroke with P= 0.001. Conclusion: Only depending on a single or a few parameters may not be sufficient, instead comprehensively combining the information from each MRI sequence (i.e., DWI, FLAIR and PWI) and using various mismatch parameters (DWI-FLAIR mismatch and/or PWI-DWI mismatch) may be more helpful in establishing an indication of MRI-based thrombolysis.

scholarly journals Histogram Analysis of MR Imaging–Derived Cerebral Blood Volume Maps: Combined Glioma Grading and Identification of Low-Grade Oligodendroglial Subtypes

2008 ◽  
Vol 29 (9) ◽  
pp. 1664-1670 ◽  
Author(s):  
K.E. Emblem ◽  
D. Scheie ◽  
P. Due-Tonnessen ◽  
B. Nedregaard ◽  
T. Nome ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Histogram Analysis ◽  
Low Grade ◽  
Glioma Grading
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