scholarly journals Molecular differences between cerebral blood volume and vessel size in glioblastoma multiforme

Oncotarget ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 11083-11093 ◽  
Author(s):  
Dieter Henrik Heiland ◽  
Theo Demerath ◽  
Elias Kellner ◽  
Valerij G. Kiselev ◽  
Dietmar Pfeifer ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vessel Size

scholarly journals Dynamic Changes in Vascular Permeability, Cerebral Blood Volume, Vascular Density, and Size after Transient Focal Cerebral Ischemia in Rats: Evaluation with Contrast-Enhanced Magnetic Resonance Imaging

2008 ◽  
Vol 28 (8) ◽  
pp. 1491-1501 ◽  
Author(s):  
Chien-Yuan Lin ◽  
Chen Chang ◽  
Wai-Mui Cheung ◽  
Ming-Huang Lin ◽  
Jean-Ju Chen ◽  
...  
Keyword(s):  
Vascular Permeability ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Focal Cerebral Ischemia ◽  
Late Phase ◽  
Vascular Density ◽  
Outer Cortex ◽  
Vessel Size ◽  
Small Vessels ◽  
Collateral Vessels

Postischemic cerebral blood flow and blood volume changes have been associated with angiogenesis; nevertheless, the spatiotemporal changes in vascular permeability, vascular density, and vessel size have not been investigated. Here we report a prolonged increase in vascular permeability from day 3 to day 21 after ischemia, in particular in the reperfused outer cortical layers and leptomeninges. Increased cerebral blood volume (CBV) was observed from day 3 to day 14, whereas increased blood volume in small vessels, primarily capillaries, was noticed from day 7 to day 14 in the reperfused cortex. An initial decrease in vascular density and a reciprocal increase in vessel size were observed within the reperfused cortex at days 1 and 3 after ischemia. Immunohistological analysis confirmed a similar decrease in microvessel density and an increase in vessel size in vessels with a diameter greater than 30 μm. These large-sized vessels exhibited intense basic fibroblast growth factor and endothelial nitric oxide synthase immunoreactivity, suggesting the growth of collateral vessels. By contrast, a late increase in vascular density was noticed in the reperfused outer cortex at days 14 and 21 after ischemia. Together, these findings suggest that the early phase of CBV increase is likely because of the improvement in collateral circulation, whereas the late phase of CBV increase is attributed to the surge of angiogenesis.

scholarly journals Visual inspection of MR relative cerebral blood volume maps has limited value for distinguishing progression from pseudoprogression in glioblastoma multiforme patients

CNS Oncology ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 297-306 ◽  
Author(s):  
Melissa Kerkhof ◽  
Pauline L Tans ◽  
Rogier E Hagenbeek ◽  
Geert J Lycklama à Nijeholt ◽  
Finn K Holla ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Blood Volume ◽  
Visual Inspection ◽  
Cerebral Blood Volume ◽  
Relative Cerebral Blood Volume

Robust MR assessment of cerebral blood volume and mean vessel size using SPION-enhanced ultrashort echo acquisition

NeuroImage ◽  
2015 ◽  
Vol 112 ◽  
pp. 382-389 ◽  
Author(s):  
S.H. Han ◽  
J.H. Cho ◽  
H.S. Jung ◽  
J.Y. Suh ◽  
J.K. Kim ◽  
...  
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vessel Size
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