scholarly journals Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery

Gene Therapy ◽  
2013 ◽  
Vol 20 (9) ◽  
pp. 930-938 ◽  
Author(s):  
A B Katwal ◽  
P R Konkalmatt ◽  
B A Piras ◽  
S Hazarika ◽  
S S Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype

scholarly journals Adeno-Associated Virus Serotype 6 Capsid Tyrosine-to-Phenylalanine Mutations Improve Gene Transfer to Skeletal Muscle

2010 ◽  
Vol 21 (10) ◽  
pp. 1343-1348 ◽  
Author(s):  
Chunping Qiao ◽  
Wei Zhang ◽  
Zhenhua Yuan ◽  
Jin-Hong Shin ◽  
Jianbin Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gene Transfer ◽  
Adeno Associated Virus ◽  
Virus Serotype

scholarly journals A Single Intravenous Injection of Adeno-associated Virus Serotype-9 Leads to Whole Body Skeletal Muscle Transduction in Dogs

2008 ◽  
Vol 16 (12) ◽  
pp. 1944-1952 ◽  
Author(s):  
Yongping Yue ◽  
Arkasubhra Ghosh ◽  
Chun Long ◽  
Brian Bostick ◽  
Bruce F Smith ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Intravenous Injection ◽  
Whole Body ◽  
Adeno Associated Virus ◽  
Single Intravenous Injection ◽  
Virus Serotype

scholarly journals Biodistribution and Safety Profile of Recombinant Adeno-Associated Virus Serotype 6 Vectors following Intravenous Delivery

2008 ◽  
Vol 82 (15) ◽  
pp. 7711-7715 ◽  
Author(s):  
Daniel Stone ◽  
Ying Liu ◽  
Zong-Yi Li ◽  
Robert Strauss ◽  
Eric E. Finn ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Side Effects ◽  
Safety Profile ◽  
Blood Cells ◽  
Neutrophil Infiltration ◽  
Minimal Effect ◽  
Coagulation Activation ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Transient Elevation

ABSTRACT Recombinant adeno-associated virus vectors based on serotype 6 (rAAV6) efficiently transduce skeletal muscle after intravenous administration and have shown efficacy in the mdx model of muscular dystrophy. As a prelude to future clinical studies, we investigated the biodistribution and safety profile of rAAV6 in mice. Although it was present in all organs tested, rAAV6 was sequestered mainly in the liver and spleen. rAAV6 had a minimal effect on circulating blood cells and caused no apparent hepatotoxicity or coagulation activation. rAAV6 caused some neutrophil infiltration into the liver, with a transient elevation in cytokine and chemokine transcription/secretion. In summary, rAAV6 induces transient toxicity that subsides almost completely within 72 h and causes no significant side effects.

scholarly journals Intersectional, anterograde transsynaptic targeting of the neurons receiving monosynaptic inputs from two upstream regions

2021 ◽  
Author(s):  
Takuma Kitanishi ◽  
Mariko Tashiro ◽  
Naomi Kitanishi ◽  
Kenji Mizuseki
Keyword(s):  
Gene Expression ◽  
Visual Cortex ◽  
Motor Cortex ◽  
Primary Visual Cortex ◽  
Dorsal Striatum ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Serotype 1 ◽  
The Brain

A brain region typically receives inputs from multiple upstream areas. However, currently, no method is available to selectively access neurons that receive monosynaptic inputs from two upstream regions. Here, we devised a method to genetically label such neurons in mice by combining the anterograde transsynaptic spread of adeno-associated virus serotype 1 (AAV1) with intersectional gene expression. Injections of AAV1s expressing either Cre or Flpo recombinases and the Cre/Flpo double-dependent AAV into two upstream regions and the downstream region, respectively, were used to label the postsynaptic neurons receiving inputs from the two upstream regions. We demonstrated this labelling in two distinct circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum. Systemic delivery of the intersectional AAV allowed for unbiased detection of the labelled neurons throughout the brain. This strategy may help analyse the interregional integration of information in the brain.

scholarly journals Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6

2004 ◽  
Vol 10 (4) ◽  
pp. 671-678 ◽  
Author(s):  
Michael J. Blankinship ◽  
Paul Gregorevic ◽  
James M. Allen ◽  
Scott Q. Harper ◽  
Hollie Harper ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adeno Associated Virus ◽  
Virus Serotype

scholarly journals Physiological Correction of Pompe Disease by Systemic Delivery of Adeno-associated Virus Serotype 1 Vectors

2007 ◽  
Vol 15 (3) ◽  
pp. 501-507 ◽  
Author(s):  
Cathryn Mah ◽  
Christina A Pacak ◽  
Kerry O Cresawn ◽  
Lara R DeRuisseau ◽  
Sean Germain ◽  
...  
Keyword(s):  
Pompe Disease ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Physiological Correction

scholarly journals Erratum to “Efficient Transduction of Skeletal Muscle Using Vectors Based on Adeno-associated Virus Serotype 6”

2009 ◽  
Vol 17 (8) ◽  
pp. 1482
Author(s):  
Michael J Blankinship ◽  
Paul Gregorevic ◽  
James M Allen ◽  
Scott Q Harper ◽  
Hollie Harper ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adeno Associated Virus ◽  
Virus Serotype
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