scholarly journals Physiological Correction of Pompe Disease by Systemic Delivery of Adeno-associated Virus Serotype 1 Vectors

2007 ◽  
Vol 15 (3) ◽  
pp. 501-507 ◽  
Author(s):  
Cathryn Mah ◽  
Christina A Pacak ◽  
Kerry O Cresawn ◽  
Lara R DeRuisseau ◽  
Sean Germain ◽  
...  
Keyword(s):  
Pompe Disease ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Physiological Correction

scholarly journals Intersectional, anterograde transsynaptic targeting of the neurons receiving monosynaptic inputs from two upstream regions

2021 ◽  
Author(s):  
Takuma Kitanishi ◽  
Mariko Tashiro ◽  
Naomi Kitanishi ◽  
Kenji Mizuseki
Keyword(s):  
Gene Expression ◽  
Visual Cortex ◽  
Motor Cortex ◽  
Primary Visual Cortex ◽  
Dorsal Striatum ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Serotype 1 ◽  
The Brain

A brain region typically receives inputs from multiple upstream areas. However, currently, no method is available to selectively access neurons that receive monosynaptic inputs from two upstream regions. Here, we devised a method to genetically label such neurons in mice by combining the anterograde transsynaptic spread of adeno-associated virus serotype 1 (AAV1) with intersectional gene expression. Injections of AAV1s expressing either Cre or Flpo recombinases and the Cre/Flpo double-dependent AAV into two upstream regions and the downstream region, respectively, were used to label the postsynaptic neurons receiving inputs from the two upstream regions. We demonstrated this labelling in two distinct circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum. Systemic delivery of the intersectional AAV allowed for unbiased detection of the labelled neurons throughout the brain. This strategy may help analyse the interregional integration of information in the brain.

Herpes Simplex Virus Clearance during Purification of a Recombinant Adeno-associated Virus Serotype 1 Vector

2014 ◽  
pp. 150127063140004
Author(s):  
Guo-jie Ye ◽  
Marina M Scotti ◽  
Darby L Thomas ◽  
Lijun Wang ◽  
David R. Knop ◽  
...  
Keyword(s):  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Adeno Associated Virus ◽  
Virus Clearance ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Simplex Virus

scholarly journals Transduction of Nonhuman Primate Brain with Adeno-Associated Virus Serotype 1: Vector Trafficking and Immune Response

2009 ◽  
Vol 20 (3) ◽  
pp. 225-237 ◽  
Author(s):  
Piotr Hadaczek ◽  
John Forsayeth ◽  
Hanna Mirek ◽  
Keith Munson ◽  
John Bringas ◽  
...  
Keyword(s):  
Immune Response ◽  
Nonhuman Primate ◽  
Adeno Associated Virus ◽  
Primate Brain ◽  
Virus Serotype ◽  
Serotype 1

scholarly journals Structure and Dynamics of Adeno-Associated Virus Serotype 1 VP1-Unique N-Terminal Domain and Its Role in Capsid Trafficking

2013 ◽  
Vol 87 (9) ◽  
pp. 4974-4984 ◽  
Author(s):  
B. Venkatakrishnan ◽  
J. Yarbrough ◽  
J. Domsic ◽  
A. Bennett ◽  
B. Bothner ◽  
...  
Keyword(s):  
Adeno Associated Virus ◽  
Structure And Dynamics ◽  
Terminal Domain ◽  
Virus Serotype ◽  
Serotype 1

Therapeutic Levels of Factor IX Expression Using a Muscle-Specific Promoter and Adeno-Associated Virus Serotype 1 Vector

2004 ◽  
Vol 15 (8) ◽  
pp. 783-792 ◽  
Author(s):  
Yi-Lin Liu ◽  
Federico Mingozzi ◽  
Sol M. Rodriguéz-Colôn ◽  
Sasha Joseph ◽  
Eric Dobrzynski ◽  
...  
Keyword(s):  
Factor Ix ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Serotype 1
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