scholarly journals A Single Intravenous Injection of Adeno-associated Virus Serotype-9 Leads to Whole Body Skeletal Muscle Transduction in Dogs

2008 ◽  
Vol 16 (12) ◽  
pp. 1944-1952 ◽  
Author(s):  
Yongping Yue ◽  
Arkasubhra Ghosh ◽  
Chun Long ◽  
Brian Bostick ◽  
Bruce F Smith ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Intravenous Injection ◽  
Whole Body ◽  
Adeno Associated Virus ◽  
Single Intravenous Injection ◽  
Virus Serotype

scholarly journals Adeno-Associated Virus Serotype 6 Capsid Tyrosine-to-Phenylalanine Mutations Improve Gene Transfer to Skeletal Muscle

2010 ◽  
Vol 21 (10) ◽  
pp. 1343-1348 ◽  
Author(s):  
Chunping Qiao ◽  
Wei Zhang ◽  
Zhenhua Yuan ◽  
Jin-Hong Shin ◽  
Jianbin Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gene Transfer ◽  
Adeno Associated Virus ◽  
Virus Serotype

scholarly journals Biodistribution and Safety Profile of Recombinant Adeno-Associated Virus Serotype 6 Vectors following Intravenous Delivery

2008 ◽  
Vol 82 (15) ◽  
pp. 7711-7715 ◽  
Author(s):  
Daniel Stone ◽  
Ying Liu ◽  
Zong-Yi Li ◽  
Robert Strauss ◽  
Eric E. Finn ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Side Effects ◽  
Safety Profile ◽  
Blood Cells ◽  
Neutrophil Infiltration ◽  
Minimal Effect ◽  
Coagulation Activation ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Transient Elevation

ABSTRACT Recombinant adeno-associated virus vectors based on serotype 6 (rAAV6) efficiently transduce skeletal muscle after intravenous administration and have shown efficacy in the mdx model of muscular dystrophy. As a prelude to future clinical studies, we investigated the biodistribution and safety profile of rAAV6 in mice. Although it was present in all organs tested, rAAV6 was sequestered mainly in the liver and spleen. rAAV6 had a minimal effect on circulating blood cells and caused no apparent hepatotoxicity or coagulation activation. rAAV6 caused some neutrophil infiltration into the liver, with a transient elevation in cytokine and chemokine transcription/secretion. In summary, rAAV6 induces transient toxicity that subsides almost completely within 72 h and causes no significant side effects.

scholarly journals Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery

Gene Therapy ◽  
2013 ◽  
Vol 20 (9) ◽  
pp. 930-938 ◽  
Author(s):  
A B Katwal ◽  
P R Konkalmatt ◽  
B A Piras ◽  
S Hazarika ◽  
S S Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype

scholarly journals Efficient transduction of skeletal muscle using vectors based on adeno-associated virus serotype 6

2004 ◽  
Vol 10 (4) ◽  
pp. 671-678 ◽  
Author(s):  
Michael J. Blankinship ◽  
Paul Gregorevic ◽  
James M. Allen ◽  
Scott Q. Harper ◽  
Hollie Harper ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adeno Associated Virus ◽  
Virus Serotype

Radioautographic Observations on the Uptake and Distribution of Chromium-51 in Mice

1972 ◽  
Vol 11 (04) ◽  
pp. 419-427
Author(s):  
R. Söremark ◽  
M. Diab
Keyword(s):  
Intravenous Injection ◽  
Placental Transfer ◽  
Whole Body ◽  
Pregnant Mother ◽  
Single Intravenous Injection ◽  
Fetal Bone ◽  
Blood Brain ◽  
Hard Tissues ◽  
Yolk Sack

SummaryThe distribuition of 51Cr has been studied in mice by whole-body radioautography after a single intravenous injection of 51CrCl3.Hard tissues, skin, liver, cartilage and yolk sack epithelium were the tissues showing the highest concentration of radiochromium. Blood, brain, muscles and the pancreas showed a low uptake of 51Cr. A placental transfer of chromium from the pregnant mother to the fetus was demonstrated. An uptake in the fetal bone and skin was visible.

scholarly journals Erratum to “Efficient Transduction of Skeletal Muscle Using Vectors Based on Adeno-associated Virus Serotype 6”

2009 ◽  
Vol 17 (8) ◽  
pp. 1482
Author(s):  
Michael J Blankinship ◽  
Paul Gregorevic ◽  
James M Allen ◽  
Scott Q Harper ◽  
Hollie Harper ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Adeno Associated Virus ◽  
Virus Serotype
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