scholarly journals Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

10.3791/55724 ◽  
2018 ◽  
Author(s):  
Naemeh Pourshafie ◽  
Philip R. Lee ◽  
Ke-lian Chen ◽  
George G. Harmison ◽  
Laura C. Bott ◽  
...  
Keyword(s):  
Neuromuscular Diseases ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype

scholarly journals Adeno-associated virus serotype 9 efficiently targets ischemic skeletal muscle following systemic delivery

Gene Therapy ◽  
2013 ◽  
Vol 20 (9) ◽  
pp. 930-938 ◽  
Author(s):  
A B Katwal ◽  
P R Konkalmatt ◽  
B A Piras ◽  
S Hazarika ◽  
S S Li ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype

scholarly journals Intersectional, anterograde transsynaptic targeting of the neurons receiving monosynaptic inputs from two upstream regions

2021 ◽  
Author(s):  
Takuma Kitanishi ◽  
Mariko Tashiro ◽  
Naomi Kitanishi ◽  
Kenji Mizuseki
Keyword(s):  
Gene Expression ◽  
Visual Cortex ◽  
Motor Cortex ◽  
Primary Visual Cortex ◽  
Dorsal Striatum ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Serotype 1 ◽  
The Brain

A brain region typically receives inputs from multiple upstream areas. However, currently, no method is available to selectively access neurons that receive monosynaptic inputs from two upstream regions. Here, we devised a method to genetically label such neurons in mice by combining the anterograde transsynaptic spread of adeno-associated virus serotype 1 (AAV1) with intersectional gene expression. Injections of AAV1s expressing either Cre or Flpo recombinases and the Cre/Flpo double-dependent AAV into two upstream regions and the downstream region, respectively, were used to label the postsynaptic neurons receiving inputs from the two upstream regions. We demonstrated this labelling in two distinct circuits: the retina/primary visual cortex to the superior colliculus and the bilateral motor cortex to the dorsal striatum. Systemic delivery of the intersectional AAV allowed for unbiased detection of the labelled neurons throughout the brain. This strategy may help analyse the interregional integration of information in the brain.

scholarly journals Physiological Correction of Pompe Disease by Systemic Delivery of Adeno-associated Virus Serotype 1 Vectors

2007 ◽  
Vol 15 (3) ◽  
pp. 501-507 ◽  
Author(s):  
Cathryn Mah ◽  
Christina A Pacak ◽  
Kerry O Cresawn ◽  
Lara R DeRuisseau ◽  
Sean Germain ◽  
...  
Keyword(s):  
Pompe Disease ◽  
Systemic Delivery ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Serotype 1 ◽  
Physiological Correction

scholarly journals Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6

2010 ◽  
Vol 16 (6) ◽  
pp. 662-664 ◽  
Author(s):  
Melodie L Weller ◽  
Panomwat Amornphimoltham ◽  
Michael Schmidt ◽  
Paul A Wilson ◽  
J Silvio Gutkind ◽  
...  
Keyword(s):  
Epidermal Growth Factor Receptor ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Growth Factor Receptor ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Epidermal Growth

Calcium-ion-modulated ceramic hydroxyapatite resin for the scalable purification of recombinant Adeno-Associated Virus serotype 9

2015 ◽  
Vol 990 ◽  
pp. 15-22 ◽  
Author(s):  
Weihong Qu ◽  
Mingxi Wang ◽  
Yaqing Wu ◽  
Yinghui Lv ◽  
Qizhao Wang ◽  
...  
Keyword(s):  
Calcium Ion ◽  
Adeno Associated Virus ◽  
Virus Serotype ◽  
Ceramic Hydroxyapatite
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