scholarly journals Antigen sensitivity evaluated by tear-specific and serum-specific IgE, skin tests, and conjunctival and nasal provocation tests in patients with ocular allergic disease

Eye ◽  
1993 ◽  
Vol 7 (3) ◽  
pp. 461-464 ◽  
Author(s):  
A Leonardi ◽  
M C Battista ◽  
M Gismondi ◽  
I A Fregona ◽  
A G Secchi
Keyword(s):  
Allergic Disease ◽  
Specific Ige ◽  
Skin Tests ◽  
Provocation Tests ◽  
Nasal Provocation

scholarly journals Peculiarities of non-allergic rhinitis with eosinophilia syndrome

2015 ◽  
Vol 12 (4) ◽  
pp. 3-7
Author(s):  
V A Utesheva ◽  
G P Bondareva ◽  
A I Kryukov ◽  
T G Barkhina
Keyword(s):  
Allergic Rhinitis ◽  
Nasal Mucosa ◽  
Specific Ige ◽  
Skin Tests ◽  
Eosinophilic Infiltration ◽  
Eosinophilic Inflammation ◽  
Nonallergic Rhinitis ◽  
Provocation Tests ◽  
Nasal Provocation ◽  
Non Allergic Rhinitis

Nonallergic rhinitis with eosinophilia syndrome (NARES) is a syndrome containing the symptoms similar to allergic rhinitis, with absence of atopy and the presence of eosinophila more than 20% in smears from nasal mucosa. Pathophysiology of NARES has not been studied completely, but permanent eosinophilic inflammation is the keystone of NARES pathogenesis. This disease is marked by local eosinophilic infiltration without atopy, confirmed by negative skin tests, normal levels of total and specific IgE in serum, negative nasal provocation tests with allergens. Nowadays this nosology is considered to be poorly understood.

Comparison between nasal provocation tests and skin tests in patients treated with loratadine and cetirizine

1999 ◽  
Vol 103 (4) ◽  
pp. 591-594 ◽  
Author(s):  
Laurence Persi ◽  
Pascal Demoly ◽  
Alan G. Harris ◽  
Bernard Tisserand ◽  
François-B. Michel ◽  
...  
Keyword(s):  
Skin Tests ◽  
Provocation Tests ◽  
Nasal Provocation

Ultrasensitive detection of specific IgE based on nanomagnetic capture and separation with AuNP-anti-IgE nanobioprobe for signal amplification

2021 ◽  
Author(s):  
Mengda Cao ◽  
Yongxin Liu ◽  
Chen Lu ◽  
Miao Guo ◽  
Lin Li ◽  
...  
Keyword(s):  
Allergic Disease ◽  
Signal Amplification ◽  
Specific Ige ◽  
Ultrasensitive Detection ◽  
Accurate Detection ◽  
Personalized Diagnosis

The accurate detection of allergen specific IgE (sIgE) is fundamental in the diagnosis of allergic disease. The present commercial platforms fail to meet the need for personalized diagnosis, due to...

scholarly journals Invited review: The role of allergen‐specific IgE, IgG and IgA in allergic disease

Allergy ◽  
2021 ◽  
Author(s):  
Mohamed H. Shamji ◽  
Rudolf Valenta ◽  
Theodore Jardetzky ◽  
Valerie Verhasselt ◽  
Stephen R. Durham ◽  
...  
Keyword(s):  
Allergic Disease ◽  
Specific Ige

Systemic reaction during intradermal skin tests with beta-lactams

2021 ◽  
Vol 14 (3) ◽  
pp. e240050
Author(s):  
Joana Carvalho ◽  
Georgeta Oliveira
Keyword(s):  
Skin Testing ◽  
Drug Hypersensitivity ◽  
Systemic Reaction ◽  
Skin Tests ◽  
Beta Lactam ◽  
Provocation Tests ◽  
Maculopapular Eruption ◽  
Intradermal Tests ◽  
Amoxicillin Clavulanate ◽  
Immediate Reactions

Beta-lactam (BL) antibiotics are the most frequent cause of drug hypersensitivity in children, inducing both immediate and non-immediate reactions. Here we report a case of a 4-year-old child with a disseminated maculopapular exanthema 7 days after the first dose of amoxicillin–clavulanate, referred to our paediatric allergy department. Skin prick tests were negative. Intradermal tests were performed and, after 10 hours, indurated wheals larger than 10×10 mm with progressive erythema and disseminated maculopapular eruption were developed, related to amoxicillin and amoxicillin–clavulanate. Systemic reactions to BL skin tests are rarely reported and the majority are immediate reactions. This case illustrates a rare example of a non-immediate systemic reaction to intradermal tests, underlying the importance of skin testing before drug provocation tests in cases of moderate to severe non-immediate reactions.

Anaphylaxis to the 23-valent pneumococcal vaccine in child: a case-control study based on immediate responses in skin tests and specific IgE determination

Vaccine ◽  
2001 ◽  
Vol 19 (32) ◽  
pp. 4588-4591 ◽  
Author(s):  
Claude Ponvert ◽  
Delia Ardelean-Jaby ◽  
Anne-Marie Colin-Gorski ◽  
Bruno Soufflet ◽  
Christine Hamberger ◽  
...  
Keyword(s):  
Pneumococcal Vaccine ◽  
Case Control Study ◽  
Specific Ige ◽  
Case Control ◽  
Skin Tests ◽  
Ige Determination ◽  
Control Study

Proficiency Survey-Based Evaluation of Clinical Total and Allergen-Specific IgE Assay Performance

2010 ◽  
Vol 134 (7) ◽  
pp. 975-982 ◽  
Author(s):  
Robert G. Hamilton
Keyword(s):  
Allergic Disease ◽  
Immunoglobulin E ◽  
Diagnostic Algorithm ◽  
Specific Ige ◽  
Total Serum ◽  
Design Data ◽  
Ige Antibody ◽  
Marked Variability ◽  
Specific Immunoglobulin E ◽  
History Of

Abstract Context.—The diagnostic algorithm for human allergic disease involves confirmation of sensitization by detection of allergen-specific immunoglobulin E (IgE) antibody in individuals suspected of having allergic disease because of a history of allergic symptoms after known allergen exposure. Previous studies showed wide disparity among clinically reported allergen-specific IgE levels from different serologic assays. Objective.—To validate the relative analytic performance (sensitivity, interassay reproducibility, linearity/parallelism, intermethod agreement) of clinically used total and allergen-specific IgE assays by using College of American Pathologists' Diagnostic Allergy “SE” Proficiency Survey data. Design.—Data from 2 SE survey cycles were used to assess relative analytic performance of the ImmunoCAP (Phadia), Immulite (Siemens Healthcare-Diagnostics), and HYTEC 288 (HYCOR-Agilent Technologies) total and allergen-specific IgE assays. In each cycle, 2 recalcified plasma pools from atopic donors were diluted twice with IgE-negative serum and evaluated in approximately 200 federally certified clinical laboratories for total IgE and IgE antibody to 5 allergen specificities. Statistical analysis evaluated analytic sensitivity, linearity, reproducibility, and intermethod agreement. Results.—Interlaboratory intramethod, intermethod, and interdilution agreement of all 6 clinically used total serum IgE assays were excellent, with coefficients of variation (CVs) below 15%. Interlaboratory intramethod, and interdilution agreement of 3 clinically used allergen-specific IgE assays were also excellent with CVs below 15%. However, intermethod CVs identified between-assay disagreement greater than 20% in 80% of allergen-specific IgE measurements. Allergen reagents and patients' immune response heterogeneity are suggested probable causes. Conclusions.—Clinical total and allergen-specific IgE assays display excellent analytic sensitivity, precision, reproducibility, and linearity. Marked variability in quantitative estimates of allergen-specific IgE from clinically used automated immunoassays is a concern that may be ameliorated with component allergen use.

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