Genetic Studies of the Relationship of Tumour–Host Cells: Detection of an Allelic Difference at a Single Gene Locus in a Small Fraction of a Large Tumour-Cell Population

Nature ◽  
1956 ◽  
Vol 178 (4547) ◽  
pp. 1389-1391 ◽  
Author(s):  
GEORGE KLEIN ◽  
EVA KLEIN
Keyword(s):  
Cell Population ◽  
Tumour Cell ◽  
Gene Locus ◽  
Single Gene ◽  
Host Cells ◽  
Large Tumour ◽  
Genetic Studies ◽  
Relationship Of ◽  
The Relationship ◽  
Tumour Cell Population

scholarly journals Tumour cell population growth inhibition and cell death induction of functionalized 6-aminoquinolone derivatives

2015 ◽  
Vol 48 (6) ◽  
pp. 705-717 ◽  
Author(s):  
G. Franci ◽  
G. Manfroni ◽  
R. Cannalire ◽  
T. Felicetti ◽  
O. Tabarrini ◽  
...  
Keyword(s):  
Cell Death ◽  
Population Growth ◽  
Growth Inhibition ◽  
Cell Population ◽  
Tumour Cell ◽  
Cell Population Growth ◽  
Tumour Cell Population

The Relationship of Opioid Analgesia to Quality of Life in an Adult Sickle Cell Population

2010 ◽  
Vol 1 (1) ◽  
pp. e29-e37 ◽  
Author(s):  
Soheir S. Adam ◽  
Marilyn J. Telen ◽  
Charles R. Jonassaint ◽  
Laura M. De Castro ◽  
Jude C. Jonassaint
Keyword(s):  
Quality Of Life ◽  
Cell Population ◽  
Sickle Cell ◽  
Opioid Analgesia ◽  
Relationship Of ◽  
The Relationship

Family and genetic studies on the relationship of schizophrenia to affective disorders

1999 ◽  
Vol 249 (S4) ◽  
pp. S57-S61 ◽  
Author(s):  
W. Maier ◽  
Marcella Rietschel ◽  
Dirk Lichtermann ◽  
Dieter B. Wildenauer
Keyword(s):  
Affective Disorders ◽  
Genetic Studies ◽  
Relationship Of ◽  
The Relationship

scholarly journals Letter Code System of Nomenclature for Puccinia graminis f. sp. avenae

Plant Disease ◽  
2007 ◽  
Vol 91 (6) ◽  
pp. 763-766 ◽  
Author(s):  
T. G. Fetch ◽  
Y. Jin
Keyword(s):  
Single Gene ◽  
Distinct Advantage ◽  
Puccinia Graminis ◽  
Nomenclature System ◽  
Letter Code ◽  
Relationship Of ◽  
The Relationship ◽  
Current Systems ◽  
Geographical Locations ◽  
New System

Current systems that describe the virulence phenotype in Puccinia graminis f. sp. avenae lack a systematic approach for the naming of races or to provide easily made comparisons of virulence among races. A new nomenclature system that simply and systematically characterizes virulence in P. graminis f. sp. avenae is described. The new system has the distinct advantage of providing easily seen relationships among races in contrast to previous nomenclature systems. This allows for easier interpretation of virulence relationships in the oat stem rust population and provides a large amount of virulence information with a minimum of written characters. This system uses single-gene differential lines with the resistance genes Pg1, Pg2, Pg3, Pg4, Pg6, Pg8, Pg9, Pg10, Pg12, Pg13, Pg15, and Pg16, grouped into three subsets of four lines in sequential Pg gene order. By grouping in sequential gene number order, the relationship of the new system to the “standard” system is easily seen. Each race is designated by a three-letter code, based on the seedling reaction (low or high) on 12 differential lines. The letter code nomenclature system is open ended and can be updated easily as new differential genes are identified. This system simply and precisely describes the virulence phenotypes of isolates of P. graminis f. sp. avenae, and allows for easily made comparisons of virulence of isolates collected over time and across geographical locations worldwide.

scholarly journals SELECTION FOR LINKAGE MODIFICATION II. A RECOMBINATION BALANCE FOR NEUTRAL MODIFIERS

Genetics ◽  
1973 ◽  
Vol 74 (4) ◽  
pp. 713-726
Author(s):  
Marcus W Feldman ◽  
Beverley Balkau
Keyword(s):  
Linkage Disequilibrium ◽  
Gene Locus ◽  
Recombination Fraction ◽  
Neutral Gene ◽  
Mean Fitness ◽  
Selection For ◽  
Relationship Of ◽  
The Relationship

ABSTRACT A stable polymorphic equilibrium may be established at a selectively-neutral gene locus which controls the extent of recombination between two other selected loci. The condition for the existence of the stable polymorphism is analogous to heterozygous advantage. The heterozygote at the modifying locus should produce a recombination fraction allowing the greatest linkage disequilibrium. In the models treated this has the effect of producing the highest mean fitness. The relationship of these findings to general problems of coadaptation is discussed.

scholarly journals Evolutionary Relationships of Pathogenic Clones of Vibrio cholerae by Sequence Analysis of Four Housekeeping Genes

1999 ◽  
Vol 67 (3) ◽  
pp. 1116-1124 ◽  
Author(s):  
Roy Byun ◽  
Liam D. H. Elbourne ◽  
Ruiting Lan ◽  
Peter R. Reeves
Keyword(s):  
Vibrio Cholerae ◽  
Gulf Coast ◽  
Single Gene ◽  
Housekeeping Genes ◽  
Gene Trees ◽  
Semialdehyde Dehydrogenase ◽  
Dehydrogenase Gene ◽  
High Level ◽  
Relationship Of ◽  
The Relationship

ABSTRACT Studies of the Vibrio cholerae population, using molecular typing techniques, have shown the existence of several pathogenic clones, mainly sixth-pandemic, seventh-pandemic, and U.S. Gulf Coast clones. However, the relationship of the pathogenic clones to environmental V. cholerae isolates remains unclear. A previous study to determine the phylogeny of V. cholerae by sequencing the asd (aspartate semialdehyde dehydrogenase) gene of V. cholerae showed that the sixth-pandemic, seventh-pandemic, and U.S. Gulf Coast clones had very differentasd sequences which fell into separate lineages in theV. cholerae population. As gene trees drawn from a single gene may not reflect the true topology of the population, we sequenced the mdh (malate dehydrogenase) and hlyA(hemolysin A) genes from representatives of environmental and clinical isolates of V. cholerae and found that the mdhand hlyA sequences from the three pathogenic clones were identical, except for the previously reported 11-bp deletion inhlyA in the sixth-pandemic clone. Identical sequences were obtained, despite average nucleotide differences in the mdhand hlyA genes of 1.52 and 3.25%, respectively, among all the isolates, suggesting that the three pathogenic clones are closely related. To extend these observations, segments of the recAand dnaE genes were sequenced from a selection of the pathogenic isolates, where the sequences were either identical or substantially different between the clones. The results show that the three pathogenic clones are very closely related and that there has been a high level of recombination in their evolution.

Mammographic density as marker of increased risk of breast cancer

2021 ◽  
pp. 41-48
Author(s):  
P. G. Labazanova ◽  
M. V. Budanova ◽  
I. I. Burdina ◽  
S. B. Zapirova ◽  
M. L. Mazo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammographic Density ◽  
Molecular Genetic ◽  
Breast Cancer Risk Factor ◽  
Develop Breast Cancer ◽  
Reproductive Age ◽  
Genetic Studies ◽  
Increased Risk ◽  
Relationship Of ◽  
The Relationship

‘Mammographic density’ (MD) is a concept that has entered medical practice since 2017. as a marker of breast cancer risk factor (BC) according to the international classifiation of NCCN. The term reflcts the degree of severity of benign diffuse breast dysplasia in women of post-reproductive age. MD is determined by the ratio of stromal, epithelial, and adipose tissue. According to the literature, in young women, high MD limits the possibilities of X-ray mammography, reducing its effectiveness in oncomammoscreening, leading to the detection of advanced forms of breast cancer. Post-reproductive women with high MD are more likely to develop breast cancer than those with low MD. In this regard, MD is of particular interest for studying its role in oncogenesis. Recent molecular genetic studies of the differences between high and low MD explain the main biological reasons why post-reproductive women with dense breast structure are at a higher risk of developing breast cancer. The aim is to identify the factors that inflence the relationship of MD with the risk of developing breast cancer based on a comparative analysis of molecular genetic studies and radiological manifestations of MD of different severity and to identify the factors that contribute to the formation of MD variants.

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