Family and genetic studies on the relationship of schizophrenia to affective disorders

1999 ◽  
Vol 249 (S4) ◽  
pp. S57-S61 ◽  
Author(s):  
W. Maier ◽  
Marcella Rietschel ◽  
Dirk Lichtermann ◽  
Dieter B. Wildenauer
Keyword(s):  
Affective Disorders ◽  
Genetic Studies ◽  
Relationship Of ◽  
The Relationship

The Relationship of Plasma to Erythrocyte Lithium Levels in Patients Taking Lithium Carbonate

1975 ◽  
Vol 127 (6) ◽  
pp. 596-598 ◽  
Author(s):  
C. R. Lee ◽  
S. E. Hill ◽  
M. Dimitrakoudi ◽  
F. A. Jenner ◽  
R. J. Pollitt
Keyword(s):  
Affective Disorders ◽  
Lithium Concentration ◽  
Lithium Carbonate ◽  
Lithium Level ◽  
Plasma Ratio ◽  
Relationship Of ◽  
The Relationship

SummaryPlasma and erythrocyte lithium levels have been determined repeatedly in twelve patients taking lithium carbonate for affective disorders. In any individual the plot of the plasma lithium level against erythrocyte/plasma ratio is linear, but the ratio can either increase or decrease with increasing plasma lithium concentration. Erythrocyte/plasma ratio is an unsound basis for comparing individual responses to lithium.

Mental Health in Africa: II. the Nature of Mental Disorder in Africa Today

1987 ◽  
Vol 151 (4) ◽  
pp. 440-446 ◽  
Author(s):  
G. Allen German
Keyword(s):  
Mental Health ◽  
Developing Countries ◽  
Mental Disorder ◽  
Affective Disorders ◽  
Clinical Issues ◽  
Physiological Abnormalities ◽  
Relationship Of ◽  
The Relationship

Aspects of clinical psychiatric syndromes described in Africa which are discussed include the issue of schizophrenic disorders having a better prognosis in developing countries; controversy over this is by no means at an end. There is an increasing realisation as to the frequency of affective disorders in Africa; while somatisation is common, cherished beliefs, such as the absence of guilt, have not been confirmed by more recent research. Nor is suicide as infrequent as has been suggested. The relationship of background physiological abnormalities of cerebral functioning may be relevant to some of the clinical issues that are currently under discussion in African psychiatry.

scholarly journals Affective Disorders in The Elderly: The Risk of Sleep Disorders

2018 ◽  
Vol 7 (1) ◽  
pp. 33
Author(s):  
Eni Folendra Rosa ◽  
Nelly Rustiaty
Keyword(s):  
Sleep Disturbance ◽  
Sleep Disorders ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Psychological Disorders ◽  
The Elderly ◽  
The Body ◽  
Physical Disorder ◽  
Relationship Of ◽  
The Relationship

The purpose of this study is to look at the relationship of sleep disorders to the incidence of affective disorders. In addition, assess whether the relationship remains significant after controlled variable bullies that also affect the occurrence of sleep disorders and or affective disorders in elderly. Observational study with unmatched case control study design. Individual population age 60 years or older, sampling probability proportional to size, consist of case group that is experiencing sleep disturbance (n=165) and control group (n=330). Respondent sleep disturbance affective disorder 23.6%. There is a significant relationship of sleep disorders to affective disorders. Sleep disorders at risk 2.47 times affective disorder. Sleep disorders can be insomnia, awakening at night or waking up too early which can lead to psychological disorders such as psychological disorders such as anger, unstable emotions, sadness, distress, anxiety is also a physical disorder such as pain in the body. If not immediately addressed can continue to occur depression and even threaten psychiatric disorders. Further research needs to be done to overcome sleep disorders in the elderly.<p> </p>

Mammographic density as marker of increased risk of breast cancer

2021 ◽  
pp. 41-48
Author(s):  
P. G. Labazanova ◽  
M. V. Budanova ◽  
I. I. Burdina ◽  
S. B. Zapirova ◽  
M. L. Mazo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mammographic Density ◽  
Molecular Genetic ◽  
Breast Cancer Risk Factor ◽  
Develop Breast Cancer ◽  
Reproductive Age ◽  
Genetic Studies ◽  
Increased Risk ◽  
Relationship Of ◽  
The Relationship

‘Mammographic density’ (MD) is a concept that has entered medical practice since 2017. as a marker of breast cancer risk factor (BC) according to the international classifiation of NCCN. The term reflcts the degree of severity of benign diffuse breast dysplasia in women of post-reproductive age. MD is determined by the ratio of stromal, epithelial, and adipose tissue. According to the literature, in young women, high MD limits the possibilities of X-ray mammography, reducing its effectiveness in oncomammoscreening, leading to the detection of advanced forms of breast cancer. Post-reproductive women with high MD are more likely to develop breast cancer than those with low MD. In this regard, MD is of particular interest for studying its role in oncogenesis. Recent molecular genetic studies of the differences between high and low MD explain the main biological reasons why post-reproductive women with dense breast structure are at a higher risk of developing breast cancer. The aim is to identify the factors that inflence the relationship of MD with the risk of developing breast cancer based on a comparative analysis of molecular genetic studies and radiological manifestations of MD of different severity and to identify the factors that contribute to the formation of MD variants.

Hsa-miR-196a2 Rs 11614913 C>T polymorphism and CRC susceptibility: A case-control study.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16066-e16066
Author(s):  
Li-zhu Chen ◽  
Yu Chen ◽  
Wei-feng Tang ◽  
Lin Chen ◽  
Jin Lin ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Smoking Status ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Genetic Studies ◽  
Incidence And Mortality ◽  
Genes Encoding ◽  
Pcr Method ◽  
Relationship Of ◽  
The Relationship

e16066 Background: The incidence and mortality rate of Colorectal cancer (CRC) is high worldwide. Many genetic studies have suggested that single nucleotide polymorphisms (SNPS) in genes encoding small molecule RNAs were associated with CRC risk, but the results were different in different studies. In our study, we investigated the general demographic characteristics and the relationship of hsa-mir-196a2 rs11614913 C > T polymorphism and CRC susceptibility in Chinese CRC. Methods: Our study included 1,003 CRC patients and 1,303 controls. Restriction fragment length polymorphism (RFLP-PCR) method was used for genotyping and SAS version 9.4 software for statistical analysis. Results: The incidence of smoking status,alcohol use and BMI in the CRC group (25.82%,17.35%,66.80%) were much higher than that in the control subjects (20.34%,10.44%,52.80%) respectively(P < 0.05). After adjusting age and other factors, hsa-mir-196a2 rs11614913 C > T genotypes were not statistically correlated with CRC risk and tumor location.But the TT genotype in the hsa-mir-196a2 rs11614913 C > T polymorphism reduced the risk of CRC in women (OR = 0.64, 95 CI: 0.42-0.97, P = 0.036). Conclusions: Smoking status,alcohol use and BMI may be main risk factors for CRC development in our study population.The polymorphism of hsa-mir-196a2 rs11614913 C > T gene may affect the risk of CRC in women, which requires further investigation in a larger cohort in the future.

Defining Schizophrenia

2017 ◽  
pp. 99-132
Author(s):  
Raquel E. Gur ◽  
Ruben C. Gur ◽  
Matcheri S. Keshavan ◽  
Christian Kohler ◽  
Elaine Walker
Keyword(s):  
Diagnostic Criteria ◽  
False Positive ◽  
Cell Biology ◽  
Neural Mechanisms ◽  
Genetic Studies ◽  
Biochemical Pathways ◽  
Basic Cell ◽  
Prevention And Treatment ◽  
Relationship Of ◽  
The Relationship

This chapter begins by describing exactly what schizophrenia is. It also defines what is meant by adolescent and adult in terms of this condition. It goes on to look at the diagnostic criteria for schizophrenia. It then considers the relationship of phenomenology to neural mechanisms. Finally, it looks at the use of phenomenology to assist in identifying the phenotype for genetic studies. Research into this area is continuous. However, some early trends are noteworthy. Some potential gene discoveries have now been replicated enough times that it is increasingly unlikely that they are false positive findings. We can also expect that the biochemical pathways represented by these genes will be explored at the level of basic cell biology and new leads about pathogenesis and potential new targets for prevention and treatment will be found. In addition, we should expect a number of studies to emerge that will try to understand whether expression of these genes are changed in the brains of schizophrenia patients. Also, efforts are already underway to try to understand how these genes influence psychological functions such as attention, sensory gating, and memory that are disturbed in schizophrenia. Finally, intense efforts will be made to try to determine whether these different genes are acting through a common pathway as, for example, has been postulated for the known genes for Alzheimer's disease.

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