Commentary. Of Mice and Men: Human Risk Assessment Based on High-Dose Rodent Exposure

1992 ◽  
Vol 5 (6) ◽  
pp. 735-736 ◽  
Author(s):  
Lawrence Marnett
Keyword(s):  
Risk Assessment ◽  
High Dose ◽  
Human Risk Assessment ◽  
Human Risk ◽  
Of Mice And Men

Risk assessment and forest pest management

1991 ◽  
Vol 67 (5) ◽  
pp. 486-492
Author(s):  
Frank N. Dost
Keyword(s):  
Risk Assessment ◽  
High Dose ◽  
Forest Pest ◽  
Potential Harm ◽  
Dose Rates ◽  
Human Risk ◽  
Forest Pest Management ◽  
The Subject ◽  
Management Method ◽  
Normal Background

Prediction of potential harm, or risk assessment, is essential to planning for any vegetation management method, but the concepts and process are often not understood. This discussion is a highly simplistic description of the basic elements of toxicology and estimation of risk in excess of the high normal background. All chemical risk is directly related to the dose acquired by the subject or population. In the case of cancer, added human risk that may be associated with very low doses is expressed as a probability that is estimated by extrapolation from observations at high dose rates. Reasons for such an indirect approach and weaknesses of the present process are described.

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