John W. (Jan) Drake: A Biochemical View of a Geneticist Par Excellence

John W. Drake died 02-02-2020, a mathematical palindrome, which he would have enjoyed, given his love of “word play and logic,” as stated in his obituary and echoed by his family, friends, students, and colleagues. Many aspects of Jan’s career have been reviewed previously, including his early years as a Caltech graduate student, and when he was editor-in-chief, with the devoted assistance of his wife Pam, of this journal for 15 impactful years. During his editorship, he raised the profile of GENETICS as the flagship journal of the Genetics Society of America and inspired and contributed to the creation of the Perspectives column, coedited by Jim Crow and William Dove. At the same time, Jan was building from scratch the Laboratory of Molecular Genetics on the newly established Research Triangle Park campus of the National Institute of Environmental Health Science, which he headed for 30 years. This commentary offers a unique perspective on Jan’s legacy; we showcase Jan’s 1969 benchmark discovery of antimutagenic T4 DNA polymerases and the research by three generations (and counting) of scientists whose research stems from that groundbreaking discovery. This is followed by a brief discussion of Jan’s passion: his overriding interest in analyzing mutation rates across species. Several anecdotal stories are included to bring alive one of Jan’s favorite phrases, “to think like a geneticist.” We feature Jan’s genetical approach to mutation studies, along with the biochemistry of DNA polymerase function, our area of expertise. But in the end, we acknowledge, as Jan did, that genetics, also known as in vivo biochemistry, prevails.

Environmental Politics of Reproduction

What constitutes “human reproduction” is under negotiation as its biology, social nature, and cultural valences are increasingly perceived as bound up in environmental issues. This review maps the growing overlap between formerly rather separate domains of reproductive politics and environmental politics, examining three interrelated areas. The first is the emergence of an intersectional environmental reproductive justice framework in activism and environmental health science. The second is the biomedical delineation of the environment of reproduction and development as an object of growing research and intervention, as well as the marking off of early-life environments as an “exposed biology” consequential to the entire life span. Third is researchers’ critical engagement with the reproductive subject of environmental politics and the lived experience of reproduction in environmentally dystopic times. Efforts to rethink the intersections of reproductive and environmental politics are found throughout these three areas.

Combining Social Science and Environmental Health Research for Community Engagement

Social science-environmental health (SS-EH) research takes many structural forms and contributes to a wide variety of topical areas. In this article we discuss the general nature of SS-EH contributions and offer a new typology of SS-EH practice that situates this type of research in a larger transdisciplinary sensibility: (1) environmental health science influenced by social science; (2) social science studies of environmental health; and (3) social science-environmental health collaborations. We describe examples from our own and others’ work and we discuss the central role that research centers, training programs, and conferences play in furthering SS-EH research. We argue that the third form of SS-EH research, SS-EH collaborations, offers the greatest potential for improving public and environmental health, though such collaborations come with important challenges and demand constant reflexivity on the part of researchers.