Indocyanine Green-Containing Nanostructure as Near Infrared Dual-Functional Targeting Probes for Optical Imaging and Photothermal Therapy

2011 ◽  
Vol 8 (2) ◽  
pp. 447-456 ◽  
Author(s):  
Xiaohui Zheng ◽  
Da Xing ◽  
Feifan Zhou ◽  
Baoyan Wu ◽  
Wei R. Chen
Keyword(s):  
Indocyanine Green ◽  
Optical Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Dual Functional

scholarly journals Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Matias Luis Picchio ◽  
Julian Bergueiro Álvarez ◽  
Stefanie Wedepohl ◽  
Roque J Minari ◽  
Cecilia Ines Alvarez Igarzabal ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Contrast Agent ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Hydrophobic Protein ◽  
Nir Dyes ◽  
Protein Pockets ◽  
J Aggregates ◽  
Innovative Concept

After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR...

scholarly journals Broad spectrum antibacterial photodynamic and photothermal therapy achieved with indocyanine green loaded SPIONs under near infrared irradiation

2020 ◽  
Vol 8 (16) ◽  
pp. 4616-4625 ◽  
Author(s):  
K. Bilici ◽  
N. Atac ◽  
A. Muti ◽  
I. Baylam ◽  
O. Dogan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Broad Spectrum ◽  
Photothermal Therapy ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Alternative Therapies ◽  
Antimicrobial Photodynamic Therapy ◽  
Infrared Irradiation ◽  
Antibiotic Resistant

Antimicrobial photodynamic therapy (aPDT) and antimicrobial photothermal therapy (aPTT) are promising local and effective alternative therapies for antibiotic resistant bacterial infections and biofilms.

A targeted agent with intercalation structure for cancer near-infrared imaging and photothermal therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (20) ◽  
pp. 16608-16614 ◽  
Author(s):  
Chunyang Li ◽  
Ruizheng Liang ◽  
Rui Tian ◽  
Shanyue Guan ◽  
Dongpeng Yan ◽  
...  
Keyword(s):  
Folic Acid ◽  
Indocyanine Green ◽  
Layered Double Hydroxide ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Near Infrared Imaging ◽  
Nir Imaging ◽  
Targeted Agent ◽  
Double Hydroxide

A new targeted photothermal agent is synthesized by co-intercalation of indocyanine green (ICG) and folic acid (FA) into the layered double hydroxide (LDH), which can be potentially used in cancer NIR imaging and photothermal therapy (PTT) field.

Controllably tuning the near-infrared plasmonic modes of gold nanoplates for enhanced optical coherence imaging and photothermal therapy

RSC Advances ◽  
2015 ◽  
Vol 5 (98) ◽  
pp. 80709-80718 ◽  
Author(s):  
Xueqin Jiang ◽  
Renming Liu ◽  
Peijun Tang ◽  
Wanbo Li ◽  
Huixiang Zhong ◽  
...  
Keyword(s):  
Optical Imaging ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Plasmon Mode ◽  
Optical Coherence ◽  
Optical Coherence Imaging ◽  
Coherence Imaging

Ozone can be used to precisely tailor the plasmon mode of gold triangular nanoprism for enhancing optical imaging and therapy.

scholarly journals A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

2016 ◽  
Vol 4 (9) ◽  
pp. 1696-1703 ◽  
Author(s):  
Shuo Huang ◽  
Paul Kumar Upputuri ◽  
Hui Liu ◽  
Manojit Pramanik ◽  
Mingfeng Wang
Keyword(s):  
Small Molecules ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Photoacoustic Signal ◽  
Colloidal Nanoparticles ◽  
Theranostic Agent ◽  
Dual Functional ◽  
Narrow Bandgap ◽  
Theranostic Agents

Colloidal nanoparticles of BBT-based narrow-bandgap small molecules as theranostic agents show a strong near-infrared photoacoustic signal and high photothermal conversion efficiency.

scholarly journals Broad Spectrum Antibacterial Photodynamic and Photothermal Therapy Achieved with Indocyanine Green Loaded SPIONs under Near Infrared Irradiation

2020 ◽  
Author(s):  
Havva Yagci acar ◽  
Kubra Bilici ◽  
Nazlı Atac ◽  
Abdullah Muti ◽  
Isınsu Baylam ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Indocyanine Green ◽  
Laser Irradiation ◽  
Laser Treatment ◽  
Photothermal Therapy ◽  
Low Dose ◽  
Near Infrared ◽  
Planktonic Cells ◽  
Gram Negative ◽  
Log Reduction

Abstract Background: Antimicrobial photodynamic therapy (aPDT) and antimicrobial photothermal therapy (aPTT) are promising local and effective alternative therapies for antibiotic resistant bacterial infections and biofilms. Combination of nanoparticles and organic photosensitizers offer a great opportunity to combine PDT and PTT for effective eradication of both planktonic bacteria and their biofilms. In this work, photo-induced antibacterial activity of indocyanine green (ICG), 3-aminopropylsilane coated superparamagnetic iron oxide nanoparticles (APTMS@SPION) and ICG loaded APTMS@SPION were evaluated on planktonic cells and biofilms of gram-negative ( E.coli , K.pneumoniae , P.aeruginosa) and gram-positive ( S.epidermis) bacteria . Results: A relatively low dose of ICG (25 mg/mL) and SPIONs (0.425 mg/mL nanoparticle) in combination with a single, short (10 min) laser irradiation at 808 nm with 1150 mW of power were used in this study. No dark toxicity of the agents or antibacterial effect of the laser irradiation were observed. The charge of the particles did not provide a significant difference in their penetration to gram-negative versus gram-positive bacterial strains or their biofilms. APTMS@SPION/laser treatment completely eliminated P.aeruginosa and provided 7-log reduction in the colony forming unit (CFU) of E.Coli, but was not effective on the other two bacteria . This is the first example for antibacterial phototoxicity of this nanoparticle. ICG/laser and ICG-APTMS@SPION/laser treatments provided complete killing of all planktonic cells . Successful eradication of all biofilms were achieved with ICG/laser (3.2-3.7 log reduction in CFU) or ICG-APTMS@SPION/laser treatment (3.3-4.4 log reduction in CFU). However, an exceptionally high, 6.5-log reduction as well as a dramatic difference between ICG versus ICG/APTMS@SPION treatment was observed in K.pneumoniae biofilms with ICG-APTMS@SPION/laser treatment. Investigation of the ROS production and increase in the local temperature of the biofilms that were subjected to phototherapy suggested a combination of aPTT and aPDT mechanisms for phototoxicity, exhibiting a synergistic effect when ICG-APTMS@SPION/laser was used. Conclusions: This approach opens an exciting and novel avenue in the fight against drug resistant infections by successfully utilizing the antimicrobial and antibiofilm activity of low dose FDA approved optically traceable ICG and a relatively low cost clinically acceptable iron oxide nanoparticle to enable effective aPDT/aPTT combination, induced via short-duration laser irradiation at a near-infrared wavelength.

scholarly journals Attachable Hydrogel Containing Indocyanine Green for Selective Photothermal Therapy against Melanoma

Biomolecules ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1124
Author(s):  
Juyoung Hwang ◽  
Jun-O Jin
Keyword(s):  
Skin Cancer ◽  
Indocyanine Green ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Target Therapy ◽  
Biocompatible Polymer ◽  
Diallyldimethylammonium Chloride ◽  
Nir Laser ◽  
Poly Acrylamide

Melanoma is the most lethal form of skin cancer because it spreads easily to other tissues, thereby decreasing the efficiency of its treatment via chemo-, radio-, and surgical therapies. We suggest the application of an attachable hydrogel for the treatment of melanoma whereby the size and amount of incorporated indocyanine green (ICG) for photothermal therapy (PTT) can be controlled. An attachable hydrogel (poly(acrylamide-co-diallyldimethylammonium chloride); PAD) that incorporates ICG as a near-infrared (NIR) absorber was fabricated using a biocompatible polymer. The temperature of PAD-ICG increases under 808 nm laser irradiation. The hydrogel protects the ICG against decomposition; consequently, PAD-ICG can be reused for PTT. The attachment of PAD-ICG to an area with melanoma in mice, with irradiation using a NIR laser, successfully eliminated melanoma. Thus, the data suggest that PAD-ICG is a smart material that could be used for selective target therapy against melanoma in humans.

scholarly journals NDs@PDA@ICG Conjugates for Photothermal Therapy of Glioblastoma Multiforme

Biomimetics ◽  
2019 ◽  
Vol 4 (1) ◽  
pp. 3 ◽  
Author(s):  
Damian Maziukiewicz ◽  
Bartosz Grześkowiak ◽  
Emerson Coy ◽  
Stefan Jurga ◽  
Radosław Mrówczyński
Keyword(s):  
Glioblastoma Multiforme ◽  
Cancer Therapy ◽  
Brain Tumors ◽  
Indocyanine Green ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Survival Rates ◽  
Modern Medicine ◽  
New Ideas

The growing incidence of cancer is a problem for modern medicine, since the therapeutic efficacy of applied modalities is still not satisfactory in terms of patients’ survival rates, especially in the case of patients with brain tumors. The destructive influence of chemotherapy and radiotherapy on healthy cells reduces the chances of full recovery. With the development of nanotechnology, new ideas on cancer therapy, including brain tumors, have emerged. Photothermal therapy (PTT) is one of these. It utilizes nanoparticles (NPs) that can convert the light, preferably in the near-infrared (NIR) region, into heat. In this paper, we report the use of nanodiamonds (NDs) conjugated with biomimetic polydopamine (PDA) and indocyanine green (ICG) for glioblastoma cancer PTT therapy. The obtained materials were thoroughly analyzed in terms of their PTT effectiveness, as well as their physicochemical properties. The performed research demonstrated that NDs@PDA@ICG can be successfully applied in the photothermal therapy of glioblastoma for PTT and exhibited high photothermal conversion efficiency η above 40%, which is almost 10 times higher than in case of bare NDs. In regard to our results, our material was found to lead to a better therapeutic outcome and higher eradication of glioblastoma cells, as demonstrated in vitro.

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