scholarly journals A dual-functional benzobisthiadiazole derivative as an effective theranostic agent for near-infrared photoacoustic imaging and photothermal therapy

2016 ◽  
Vol 4 (9) ◽  
pp. 1696-1703 ◽  
Author(s):  
Shuo Huang ◽  
Paul Kumar Upputuri ◽  
Hui Liu ◽  
Manojit Pramanik ◽  
Mingfeng Wang
Keyword(s):  
Small Molecules ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Photoacoustic Signal ◽  
Colloidal Nanoparticles ◽  
Theranostic Agent ◽  
Dual Functional ◽  
Narrow Bandgap ◽  
Theranostic Agents

Colloidal nanoparticles of BBT-based narrow-bandgap small molecules as theranostic agents show a strong near-infrared photoacoustic signal and high photothermal conversion efficiency.

Heteropoly blue doped polymer nanoparticles: an efficient theranostic agent for targeted photoacoustic imaging and near-infrared photothermal therapy in vivo

2017 ◽  
Vol 5 (2) ◽  
pp. 382-387 ◽  
Author(s):  
Yuping Yan ◽  
Qi Yang ◽  
Jie Wang ◽  
Hongyu Jin ◽  
Jing Wang ◽  
...  
Keyword(s):  
Light Absorption ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Polymer Nanoparticles ◽  
Step Process ◽  
Theranostic Agent ◽  
Nir Light ◽  
Doped Polymer

We report a two-step process to construct heteropoly blue (HPB) doped polymer nanoparticles with efficient near-infrared (NIR) light absorption and photothermal conversion efficiency of ∼23%.

Pyrazino[2,3-g]quinoxaline-Based Nanoparticles as Near-Infrared Phototheranostic Agents for Efficient Photoacoustic-Imaging-Guided Photothermal Therapy

2021 ◽  
Vol 4 (2) ◽  
pp. 2019-2029
Author(s):  
Li-Peng Zhang ◽  
Lin Kang ◽  
Xianqiang Li ◽  
Shiyang Liu ◽  
Tianlong Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Near Infrared ◽  
Photoacoustic Imaging

Core-Shell Pd@Au Nanoplates as Theranostic Agents for In-Vivo Photoacoustic Imaging, CT Imaging, and Photothermal Therapy

2014 ◽  
Vol 26 (48) ◽  
pp. 8210-8216 ◽  
Author(s):  
Mei Chen ◽  
Shaoheng Tang ◽  
Zhide Guo ◽  
Xiaoyong Wang ◽  
Shiguang Mo ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Ct Imaging ◽  
Core Shell ◽  
Theranostic Agents

scholarly journals Bacteria-triggered tumor-specific thrombosis to enable potent photothermal immunotherapy of cancer

2020 ◽  
Vol 6 (33) ◽  
pp. eaba3546 ◽  
Author(s):  
Xuan Yi ◽  
Hailin Zhou ◽  
Yu Chao ◽  
Saisai Xiong ◽  
Jing Zhong ◽  
...  
Keyword(s):  
Immune Responses ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Immune Checkpoint Blockade ◽  
Immune Memory ◽  
Immunotherapy Of Cancer ◽  
Rapid Clearance ◽  
Inhibit Tumor Metastasis

We discovered that attenuated Salmonella after intravenous injection would proliferate within various types of solid tumors but show rapid clearance in normal organs, without rendering notable toxicity. Bacteria-induced inflammation would trigger thrombosis in the infected tumors by destroying tumor blood vessels. Six types of tested tumors would all turn into darkened color with strong near-infrared absorbance, as observed by photoacoustic imaging. Under laser irradiation, those bacterial-infected tumors would be effectively ablated. Because of the immune-stimulation function, such bacteria-based photothermal therapy (PTT) would subsequently trigger antitumor immune responses, which could be further enhanced by immune checkpoint blockade to effectively suppress the growth of abscopal tumors. A robust immune memory effect to reject rechallenged tumors is also observed after bacteria-based PTT. Our work demonstrates that bacteria by themselves could act as a tumor-specific PTT agent to enable photoimmunotherapy cancer therapy to inhibit tumor metastasis and recurrence.

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