scholarly journals Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: An innovative concept for smart nanotheranostics

Nanoscale ◽  
2021 ◽  
Author(s):  
Matias Luis Picchio ◽  
Julian Bergueiro Álvarez ◽  
Stefanie Wedepohl ◽  
Roque J Minari ◽  
Cecilia Ines Alvarez Igarzabal ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Contrast Agent ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Cyanine Dye ◽  
Hydrophobic Protein ◽  
Nir Dyes ◽  
Protein Pockets ◽  
J Aggregates ◽  
Innovative Concept

After several decades of development in the field of near-infrared (NIR) dyes for photothermal therapy (PTT), indocyanine green (ICG) still remains the only FDA-approved NIR contrast agent. However, upon NIR...

scholarly journals NIR-Emitting Benzene-Fused Oligo-BODIPYs for Bioimaging

2021 ◽  
Author(s):  
Gabriele Selvaggio ◽  
Robert Nißler ◽  
Peter Nietmann ◽  
Atanu Patra ◽  
Lukas Jacek Patalag ◽  
...  
Keyword(s):  
Particle Tracking ◽  
Near Infrared ◽  
Bathochromic Shift ◽  
Visible Region ◽  
Tissue Penetration ◽  
Actin Networks ◽  
Nir Dyes ◽  
Nir Fluorescence ◽  
J Aggregates ◽  
20 Nm

Near-infrared (NIR) fluorophores are emerging tools for biophotonics because of their reduced scattering, increased tissue penetration and low phototoxicity. However, the library of NIR fluorophores is still limited. Here, we report the NIR fluorescence of two benzene-fused oligo-BODIPYs in their hexameric (H) and octameric (O) forms. These dyes emit bright NIR fluorescence (H: maxima 943/1075 nm, O: maxima 976/1115 nm) that can be excited in the NIR (H = 921 nm, O = 956 nm) or non-resonantly over a broad range in the visible region. The emission bands of H show a bathochromic shift and peak sharpening with increasing dye concentration suggesting the presence of J-aggregates. Furthermore, the emission maxima of both H and O shift up to 20 nm in solvents of different polarity. These dyes can be used as NIR ink and imaged remotely on the macroscopic level with a stand-off distance of 20 cm. We furthermore demonstrate their versatility for biophotonics by coating microscale beads and performing microrheology via NIR video particle tracking (NIR-VPT) in biopolymer (F-actin) networks. No photodamaging of the actin filaments takes place, which is typically observed for visible fluorophores and highlights the advantages of these NIR dyes.

scholarly journals Broad spectrum antibacterial photodynamic and photothermal therapy achieved with indocyanine green loaded SPIONs under near infrared irradiation

2020 ◽  
Vol 8 (16) ◽  
pp. 4616-4625 ◽  
Author(s):  
K. Bilici ◽  
N. Atac ◽  
A. Muti ◽  
I. Baylam ◽  
O. Dogan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Broad Spectrum ◽  
Photothermal Therapy ◽  
Bacterial Infections ◽  
Near Infrared ◽  
Alternative Therapies ◽  
Antimicrobial Photodynamic Therapy ◽  
Infrared Irradiation ◽  
Antibiotic Resistant

Antimicrobial photodynamic therapy (aPDT) and antimicrobial photothermal therapy (aPTT) are promising local and effective alternative therapies for antibiotic resistant bacterial infections and biofilms.

Thermo- and photo-stable symmetrical benzo[cd]indolenyl-substituted heptamethine cyanine dye carrying a tetrakis(pentafluorophenyl)borate that absorbs only near-infrared light over 1000 nm

2019 ◽  
Vol 43 (19) ◽  
pp. 7491-7501
Author(s):  
Kazumasa Funabiki ◽  
Ryuta Yanagawa ◽  
Yasuhiro Kubota ◽  
Toshiyasu Inuzuka
Keyword(s):  
Near Infrared ◽  
Cyanine Dye ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Dyes ◽  
Nir Light

Thermo- and photo-stable NIR dyes absorbing only NIR light of over 1000 nm have been investigated.

A targeted agent with intercalation structure for cancer near-infrared imaging and photothermal therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (20) ◽  
pp. 16608-16614 ◽  
Author(s):  
Chunyang Li ◽  
Ruizheng Liang ◽  
Rui Tian ◽  
Shanyue Guan ◽  
Dongpeng Yan ◽  
...  
Keyword(s):  
Folic Acid ◽  
Indocyanine Green ◽  
Layered Double Hydroxide ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Near Infrared Imaging ◽  
Nir Imaging ◽  
Targeted Agent ◽  
Double Hydroxide

A new targeted photothermal agent is synthesized by co-intercalation of indocyanine green (ICG) and folic acid (FA) into the layered double hydroxide (LDH), which can be potentially used in cancer NIR imaging and photothermal therapy (PTT) field.

scholarly journals Principles for Self-Assembly of Cyanine Dyes into 2-Dimensional Excitonic Aggregates Across the Visible and Near-Infrared

2020 ◽  
Author(s):  
Arundhati Deshmukh ◽  
Austin Bailey ◽  
Leandra Forte ◽  
Xingyu Shen ◽  
Niklas Geue ◽  
...  
Keyword(s):  
Self Assembly ◽  
Near Infrared ◽  
Dynamic Equilibrium ◽  
Structural Information ◽  
Photophysical Properties ◽  
Cyanine Dyes ◽  
Cyanine Dye ◽  
Extensive Literature ◽  
Solvent Ratio ◽  
J Aggregates

<div>Cyanine dyes show a remarkable tendency to form non-covalent supramolecular aggregates with diverse morphologies (dimers, sheets, tubes and bundles). Specific molecular arrangements within these H- or J-aggregates dictate the extraordinary photophysical properties, including long-range exciton delocalization, extreme redshifts, and excitonic superradiance. Despite extensive literature on cyanine dye aggregates, design principles that drive the solution self-assembly to a preferred H- or J-aggregated state are unknown. We present a general approach to tune the thermodynamics of self-assembly, selectively stabilizing H- or J-aggregates and thereby achieving supramolecular control over aggregate photophysics. A simple interplay of solvent to non-solvent ratio, ionic strength or dye concentration yields a broad range of conditions that predictably and preferentially stabilize the monomer, H- or J-aggregate species that can be easily monitored using absorption spectroscopy. Diffusion ordered spectroscopy, cryo-electron microscopy and atomic force microscopy together reveal a dynamic equilibrium between monomers, H-aggregated dimers, and extended J-aggregated 2-dimensional monolayers. This structural information informs a three-component equilibrium model that describes the observed concentration dependence of spectral signatures, showing excellent fit with experimental data and yields the Gibb’s free energies of self-assembly for dimerization and 2D aggregate assembly. We further demonstrate the universality of this approach among several sheet forming cyanine dyes including the benzothiazole and benzimidazole families with absorptions spanning visible, near and shortwave infrared wavelengths.</div>

scholarly journals Comparative Study of the Optical and Heat Generation Properties of IR820 and Indocyanine Green

2012 ◽  
Vol 11 (2) ◽  
pp. 7290.2011.00031 ◽  
Author(s):  
Alicia Fernandez-Fernandez ◽  
Romila Manchanda ◽  
Tingjun Lei ◽  
Denny A. Carvajal ◽  
Yuan Tang ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Experimental Models ◽  
Cyanine Dye ◽  
Laser Exposure ◽  
Fluorescence Signal ◽  
Thermal Generation ◽  
Significant Difference

Near-infrared (NIR) fluorophores are the focus of extensive research for combined molecular imaging and hyperthermia. In this study, we showed that the cyanine dye IR820 has optical and thermal generation properties similar to those of indocyanine green (ICG) but with improved in vitro and in vivo stability. The fluorescent emission of IR820 has a lower quantum yield than ICG but less dependence of the emission peak location on concentration. IR820 demonstrated degradation half-times approximately double those of ICG under all temperature and light conditions in aqueous solution. In hyperthermia applications, IR820 generated lower peak temperatures than ICG (4–9%) after 3-minute laser exposure. However, there was no significant difference in hyperthermia cytotoxicity, with both dyes causing significant cell growth inhibition at concentrations ≥ 5 μM. Fluorescent images of cells with 10 μM IR820 were similar to ICG images. In rats, IR820 resulted in a significantly more intense fluorescence signal and significantly higher organ dye content than for ICG 24 hours after intravenous dye administration ( p < .05). Our study shows that IR820 is a feasible agent in experimental models of imaging and hyperthermia and could be an alternative to ICG when greater stability, longer image collection times, or more predictable peak locations are desirable.

Indocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging

2019 ◽  
Vol 11 (50) ◽  
pp. 46437-46450 ◽  
Author(s):  
Behzad Changalvaie ◽  
Sangheon Han ◽  
Ehsan Moaseri ◽  
Federica Scaletti ◽  
Lauren Truong ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
J Aggregates

scholarly journals Liposome-Templated Indocyanine Green J- Aggregates for In Vivo Near Infrared Imaging and Stable Photothermal Heating

2020 ◽  
Vol 4 (2) ◽  
pp. 91-106 ◽  
Author(s):  
Calvin C. L. Cheung ◽  
Guanglong Ma ◽  
Kostas Karatasos ◽  
Jani Seitsonen ◽  
Janne Ruokolainen ◽  
...  
Keyword(s):  
Indocyanine Green ◽  
Near Infrared ◽  
Infrared Imaging ◽  
Near Infrared Imaging ◽  
Photothermal Heating ◽  
J Aggregates
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