Synthesis of Well-Defined Semitelechelic Poly[N-(2-hydroxypropyl)methacrylamide] Polymers with Functional Group at the α-End of the Polymer Chain by RAFT Polymerization

2013 ◽  
Vol 46 (6) ◽  
pp. 2100-2108 ◽  
Author(s):  
V. Šubr ◽  
L. Kostka ◽  
J. Strohalm ◽  
T. Etrych ◽  
K. Ulbrich
Keyword(s):  
Polymer Chain ◽  
Functional Group ◽  
Raft Polymerization ◽  
Hydroxypropyl Methacrylamide

Microwave-assisted RAFT polymerization of N-(2-hydroxypropyl) methacrylamide and its relevant copolymers

2021 ◽  
Vol 162 ◽  
pp. 104875
Author(s):  
Vladimir Sincari ◽  
Svetlana Lukáš Petrova ◽  
Rafał Konefał ◽  
Martin Hruby ◽  
Eliézer Jäger
Keyword(s):  
Raft Polymerization ◽  
Microwave Assisted ◽  
Hydroxypropyl Methacrylamide

Diversifying Polyhydroxyalkanoates – End-Group and Side-Chain Functionality

2017 ◽  
Vol 14 (6) ◽  
pp. 757-767 ◽  
Author(s):  
Michal Michalak ◽  
Iwona Kwiecien ◽  
Michal Kwiecien ◽  
Grazyna Adamus ◽  
Karin Odelius ◽  
...  
Keyword(s):  
Functional Groups ◽  
Polymer Chain ◽  
Ring Opening ◽  
Functional Group ◽  
Side Chain ◽  
Natural Origin ◽  
Polymer Formation ◽  
End Groups ◽  
Group Diversity ◽  
End Group

Background: Polyhydroxyalkanoates (PHAs) are a natural origin biodegradable polyesters consisted of various 3- and 4-hydroxyacid derived repeating units produced by microorganisms as energy storage. PHAs have been intensively studied due to their biodegradability and biocompatibility enabling their use both in packaging and agriculture as well as in medicine and pharmacy. PHAs obtained via biotechnological routes can possess various functional groups in their side chains. However, the diversity in their functionality is limited due to issues of conservation of functional groups during the polymer formation. Objective: The review focuses on recent progress in the area of synthesis of PHAs functionalized with various reactive as well as bioactive end and side groups. Conclusion: A potent route to resolve the problem of functional group diversity in natural origin PHAs involves post-polymerization modification, where the desired side groups can be created. On the contrary, synthetically produced PHA analogs obtained directly via ring-opening polymerization of β-lactones offer various functionalities at different position throughout the polymer chain. The desired α- and ω-end groups can be introduced into the polymer chain using specific polymerization, initiation or termination strategies, respectively. The preferred side chain functionality is obtained by choosing the appropriate β-lactone monomers bearing respective functional groups. All functional groups may also be subjected to additional chemical modification. The degradation of PHA as a method for producing functional polymers as well as their possible further applications are also discussed.

scholarly journals Effects of terminal group and chain length on temperature-responsive chromatography utilizing poly(N-isopropylacrylamide) synthesized via RAFT polymerization

RSC Advances ◽  
2015 ◽  
Vol 5 (89) ◽  
pp. 73217-73224 ◽  
Author(s):  
Yuki Hiruta ◽  
Yuhei Nagumo ◽  
Atsushi Miki ◽  
Teruo Okano ◽  
Hideko Kanazawa
Keyword(s):  
Chain Length ◽  
Functional Group ◽  
Raft Polymerization ◽  
Stationary Phases ◽  
Terminal Group ◽  
Temperature Dependent ◽  
Temperature Responsive ◽  
Silica Beads ◽  
Elution Behavior ◽  
Terminal Functional Group

Even using the same homo poly(N-isopropylacrylamide) immobilized silica beads as stationary phases, terminal functional group and chain length significantly affected temperature-dependent elution behavior of steroids.

Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

2014 ◽  
Vol 5 (5) ◽  
pp. 1711-1719 ◽  
Author(s):  
Harald Wutzel ◽  
Felix H. Richter ◽  
Yuanchao Li ◽  
Sergei S. Sheiko ◽  
Harm-Anton Klok
Keyword(s):  
Raft Polymerization ◽  
Inverse Emulsion ◽  
Hydroxypropyl Methacrylamide

RAFT Polymerization of 2,2,3,3-Tetrafluoropropyl Methacrylate in the Presence of Lewis Acids

2021 ◽  
Vol 899 ◽  
pp. 525-531
Author(s):  
Oleg A. Lebedev ◽  
Alexandra O. Grigoreva ◽  
Sergey D. Zaitsev
Keyword(s):  
Polymer Chain ◽  
Lewis Acids ◽  
Chain Transfer ◽  
Raft Polymerization ◽  
Point Of View ◽  
Chain Transfer Agent ◽  
Reversible Addition

The influence of various tacticity regulators on the reversible addition-fragmentation (RAFT) polymerization of 2,2,3,3-tetrafluoropropyl methacrylate in the presence of 2-cyano-2-propyldodecyltritiocarbonate as an chain transfer agent was investigated. Among Lewis acids considered, the polymerization of TFPMA in dioxane with ZnBr2 turned out to be the most effective from the point of view of tacticity; the polymer with the highest isotacticity is formed. The addition of hexafluoroisopropanol leads to an increase in the heterotacticity and a decrease in the isotacticity of the polymer chain.

Synthesis of siRNA Polyplexes Adopting a Combination of RAFT Polymerization and Thiol-ene Chemistry

2009 ◽  
Vol 62 (10) ◽  
pp. 1344 ◽  
Author(s):  
David Valade ◽  
Cyrille Boyer ◽  
Thomas P. Davis ◽  
Volga Bulmus
Keyword(s):  
Block Copolymers ◽  
High Efficiency ◽  
Raft Polymerization ◽  
Hydrodynamic Diameter ◽  
Small Interfering Rnas ◽  
Buffer Solution ◽  
Polyelectrolyte Complexes ◽  
Reversible Addition ◽  
Hydroxypropyl Methacrylamide ◽  
Cationic Copolymers

Block copolymers of allyl methacrylate and N-(2-hydroxypropyl)methacrylamide (HPMA) with different block lengths have been synthesized by reversible addition–fragmentation chain transfer polymerization. Allyl groups were modified with cysteamine, via a thiol-ene photoreaction, with a high efficiency (~100%) as evidenced by NMR spectroscopy, yielding cationic copolymers of HPMA. Polyelectrolyte complexes of small interfering RNAs (siRNA) and the cationic block copolymers were then formed at an N/P ratio between 1 and 4 depending on the block length of the copolymers. Increasing the length of the hydrophilic block was found to decrease the efficiency of siRNA complexation. The hydrodynamic diameter of the polyplexes in 130 mM buffer solution was less than 100 nm.

Synthesis of poly(N-(2-hydroxypropyl) methacrylamide) brushes by interface-mediated RAFT polymerization

RSC Advances ◽  
2016 ◽  
Vol 6 (51) ◽  
pp. 45259-45264 ◽  
Author(s):  
Ertan Yildirim ◽  
Dilek Cimen ◽  
Adem Zengin ◽  
Tuncer Caykara
Keyword(s):  
Raft Polymerization ◽  
Polymer Brush ◽  
Moderate Density ◽  
Hydroxypropyl Methacrylamide

A novel poly(N-(2-hydroxypropyl) methacrylamide) [poly(HPMA)] brush with a moderate density polymer brush (0.52 chains per nm2) was synthesized by an interface-mediated RAFT polymerization.

Immobilization of RAFT agents on silica nanoparticles utilizing an alternative functional group and subsequent surface-initiated RAFT polymerization

2009 ◽  
Vol 47 (2) ◽  
pp. 467-484 ◽  
Author(s):  
Yingkui Yang ◽  
Zhifang Yang ◽  
Qiang Zhao ◽  
Xinjian Cheng ◽  
Sie Chin Tjong ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Functional Group ◽  
Raft Polymerization
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