Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

2014 ◽  
Vol 5 (5) ◽  
pp. 1711-1719 ◽  
Author(s):  
Harald Wutzel ◽  
Felix H. Richter ◽  
Yuanchao Li ◽  
Sergei S. Sheiko ◽  
Harm-Anton Klok
Keyword(s):  
Raft Polymerization ◽  
Inverse Emulsion ◽  
Hydroxypropyl Methacrylamide

Microwave-assisted RAFT polymerization of N-(2-hydroxypropyl) methacrylamide and its relevant copolymers

2021 ◽  
Vol 162 ◽  
pp. 104875
Author(s):  
Vladimir Sincari ◽  
Svetlana Lukáš Petrova ◽  
Rafał Konefał ◽  
Martin Hruby ◽  
Eliézer Jäger
Keyword(s):  
Raft Polymerization ◽  
Microwave Assisted ◽  
Hydroxypropyl Methacrylamide

Synthesis of microcapsules using inverse emulsion periphery RAFT polymerization via SPG membrane emulsification

2016 ◽  
Vol 7 (46) ◽  
pp. 7047-7051 ◽  
Author(s):  
Fumi Ishizuka ◽  
Rhiannon P. Kuchel ◽  
Hongxu Lu ◽  
Martina H. Stenzel ◽  
Per B. Zetterlund
Keyword(s):  
Particle Size ◽  
Size Distribution ◽  
Raft Polymerization ◽  
Good Control ◽  
Membrane Emulsification ◽  
Inverse Emulsion ◽  
Novel Approach ◽  
Spg Membrane Emulsification

Synthesis of polymeric capsules with good control over the particle size and size distribution is demonstratedviaa novel approach involving SPG membrane emulsification.

Synthesis of siRNA Polyplexes Adopting a Combination of RAFT Polymerization and Thiol-ene Chemistry

2009 ◽  
Vol 62 (10) ◽  
pp. 1344 ◽  
Author(s):  
David Valade ◽  
Cyrille Boyer ◽  
Thomas P. Davis ◽  
Volga Bulmus
Keyword(s):  
Block Copolymers ◽  
High Efficiency ◽  
Raft Polymerization ◽  
Hydrodynamic Diameter ◽  
Small Interfering Rnas ◽  
Buffer Solution ◽  
Polyelectrolyte Complexes ◽  
Reversible Addition ◽  
Hydroxypropyl Methacrylamide ◽  
Cationic Copolymers

Block copolymers of allyl methacrylate and N-(2-hydroxypropyl)methacrylamide (HPMA) with different block lengths have been synthesized by reversible addition–fragmentation chain transfer polymerization. Allyl groups were modified with cysteamine, via a thiol-ene photoreaction, with a high efficiency (~100%) as evidenced by NMR spectroscopy, yielding cationic copolymers of HPMA. Polyelectrolyte complexes of small interfering RNAs (siRNA) and the cationic block copolymers were then formed at an N/P ratio between 1 and 4 depending on the block length of the copolymers. Increasing the length of the hydrophilic block was found to decrease the efficiency of siRNA complexation. The hydrodynamic diameter of the polyplexes in 130 mM buffer solution was less than 100 nm.

Synthesis of poly(N-(2-hydroxypropyl) methacrylamide) brushes by interface-mediated RAFT polymerization

RSC Advances ◽  
2016 ◽  
Vol 6 (51) ◽  
pp. 45259-45264 ◽  
Author(s):  
Ertan Yildirim ◽  
Dilek Cimen ◽  
Adem Zengin ◽  
Tuncer Caykara
Keyword(s):  
Raft Polymerization ◽  
Polymer Brush ◽  
Moderate Density ◽  
Hydroxypropyl Methacrylamide

A novel poly(N-(2-hydroxypropyl) methacrylamide) [poly(HPMA)] brush with a moderate density polymer brush (0.52 chains per nm2) was synthesized by an interface-mediated RAFT polymerization.

Effect of solvents on the RAFT polymerization of N-(2-hydroxypropyl) methacrylamide

2019 ◽  
Vol 115 ◽  
pp. 166-172 ◽  
Author(s):  
Xiangyu Pan ◽  
Fenming Zhang ◽  
Bonnie Choi ◽  
Yanlong Luo ◽  
Xiaofeng Guo ◽  
...  
Keyword(s):  
Raft Polymerization ◽  
Effect Of Solvents ◽  
Hydroxypropyl Methacrylamide

Synthesis and Photoproperties of a Substituted Zinc(II) Phthalocyanine-N-(2-hydroxypropyl)methacrylamide Copolymer Conjugate

1993 ◽  
Vol 58 (10) ◽  
pp. 2321-2336 ◽  
Author(s):  
Zhong-wei Gu ◽  
John D. Spikes ◽  
Pavla Kopečková ◽  
Jindřich Kopeček
Keyword(s):  
Organic Solvents ◽  
Water Soluble ◽  
Lower Probability ◽  
Hpma Copolymer ◽  
Polymeric Derivative ◽  
Oxygen Generation ◽  
Hpma Copolymers ◽  
Hydroxypropyl Methacrylamide ◽  
Polymeric Carriers ◽  
Thiol Proteinases

In cancer photodynamic therapy (PDT), improved efficiency of photosensitizer delivery to tumors may be obtained by binding them to targetable water soluble polymeric carriers. However, attachment of photosensitizers to Macromolecular carriers may alter their spectral and photosensitizing properties. In this study, a new monosubstituted phthalocyanine derivative, N-glycyl zinc(II) 4,9,16,23-tetraaminophthalocyanine (G-TAPC-Zn) was synthesized by the reaction of zinc(II) 4,9,16,23-tetraaminophthalocyanine (TAPC-Zn) with N-tert-butoxycarbonyl-glycine N'-hydroxybenzotriazole ester followed by deprotection of the tert-butoxycarbonyl (BOC) group. G-TAPC-Zn contains an aliphatic amino group suitable for attachment to water soluble polymeric carriers. By aminolysis of a polymeric precursor, an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer containing oligopeptide (GFLG) side-chains terminated in p-nitrophenyl ester groups, with G-TAPC-Zn a polymeric derivative of the latter (P-GFLGG-TAPC-Zn) was synthesized. Spectral data indicated that in aqueous solutions P-GFLGG-TAPC-Zn formed aggregates. The degree of aggregation decreased with increasing concentration of detergents or organic solvents in buffer solutions. Consequently, the release of the drug from carrier catalyzed by thiol proteinases, papain or cathepsin B, took place only in the presence of detergents or organic solvents, i.e., under conditions with a lower probability of aggregate formation. Binding of G-TAPC-Zn to HPMA copolymers decreased the quantum yield of singlet oxygen generation from 0.24 to 0.063 and significantly increased its resistance to photobleaching.

Optimizing the Cu-RDRP ofN-(2-hydroxypropyl) methacrylamide toward biomedical applications

2019 ◽  
Vol 10 (5) ◽  
pp. 564-568 ◽  
Author(s):  
Vladimír Raus ◽  
Libor Kostka
Keyword(s):  
Molecular Weight ◽  
Biomedical Applications ◽  
Hydroxypropyl Methacrylamide

Aqueous Cu-RDRP ofN-(2-hydroxypropyl) methacrylamide was optimized to achieve co(polymers) of low dispersity and controlled molecular weight at high conversions.

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