Molecular Modeling of the Aldose Reductase-Inhibitor Complex Based on the X-ray Crystal Structure and Studies with Single-Site-Directed Mutants

2000 ◽  
Vol 43 (6) ◽  
pp. 1062-1070 ◽  
Author(s):  
Suresh B. Singh ◽  
Michael S. Malamas ◽  
Thomas C. Hohman ◽  
Ramaswamy Nilakantan ◽  
Deborah A. Carper ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Modeling ◽  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Single Site ◽  
X Ray ◽  
Inhibitor Complex

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

2006 ◽  
Vol 35 (7) ◽  
pp. 577-583 ◽  
Author(s):  
M. P. Blakeley ◽  
A. Mitschler ◽  
I. Hazemann ◽  
F. Meilleur ◽  
D. A. A. Myles ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
X Ray ◽  
Inhibitor Complex ◽  
Neutron Crystallography

X-ray structure of the V301L aldo–keto reductase 1B10 complexed with NADP+ and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity

2013 ◽  
Vol 202 (1-3) ◽  
pp. 178-185 ◽  
Author(s):  
Francesc Xavier Ruiz ◽  
Alexandra Cousido-Siah ◽  
André Mitschler ◽  
Jaume Farrés ◽  
Xavier Parés ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Inhibitor Binding ◽  
X Ray

Ultrahigh resolution drug design I: Details of interactions in human aldose reductase-inhibitor complex at 0.66 Å

2004 ◽  
Vol 55 (4) ◽  
pp. 792-804 ◽  
Author(s):  
E.I. Howard ◽  
R. Sanishvili ◽  
R.E. Cachau ◽  
A. Mitschler ◽  
B. Chevrier ◽  
...  
Keyword(s):  
Drug Design ◽  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Ultrahigh Resolution ◽  
Inhibitor Complex
Sign in / Sign up

Export Citation Format

Share Document