Effect of an aldose reductase inhibitor, AL-1576, on the development of UV-B and X-ray cataract

1988 ◽  
Vol 226 (5) ◽  
pp. 455-460 ◽  
Author(s):  
C. Schmitt ◽  
J. Schmidt ◽  
A. Wegener ◽  
O. Hockwin
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
X Ray

X-ray structure of the V301L aldo–keto reductase 1B10 complexed with NADP+ and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity

2013 ◽  
Vol 202 (1-3) ◽  
pp. 178-185 ◽  
Author(s):  
Francesc Xavier Ruiz ◽  
Alexandra Cousido-Siah ◽  
André Mitschler ◽  
Jaume Farrés ◽  
Xavier Parés ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Inhibitor Binding ◽  
X Ray

Molecular Modeling of the Aldose Reductase-Inhibitor Complex Based on the X-ray Crystal Structure and Studies with Single-Site-Directed Mutants

2000 ◽  
Vol 43 (6) ◽  
pp. 1062-1070 ◽  
Author(s):  
Suresh B. Singh ◽  
Michael S. Malamas ◽  
Thomas C. Hohman ◽  
Ramaswamy Nilakantan ◽  
Deborah A. Carper ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Modeling ◽  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Single Site ◽  
X Ray ◽  
Inhibitor Complex

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

2006 ◽  
Vol 35 (7) ◽  
pp. 577-583 ◽  
Author(s):  
M. P. Blakeley ◽  
A. Mitschler ◽  
I. Hazemann ◽  
F. Meilleur ◽  
D. A. A. Myles ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
X Ray ◽  
Inhibitor Complex ◽  
Neutron Crystallography

186-OR: Safety and Tolerability of the Next Generation Aldose Reductase Inhibitor (ARI) AT-001 Supports Initiation of the Pivotal Trial in Diabetic Cardiomyopathy (DbCM)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 186-OR
Author(s):  
RICCARDO PERFETTI ◽  
FRANCESCA C. LAWSON ◽  
JULIO ROSENSTOCK ◽  
JAMES JANUZZI ◽  
SHOSHANA SHENDELMAN ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Cardiomyopathy ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Pivotal Trial ◽  
Next Generation
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