A Potent Aldose Reductase Inhibitor, (2S,4S)-6-Fluoro-2‘,5‘-dioxospiro[chroman-4,4‘-imidazolidine]-2-carboxamide (Fidarestat):  Its Absolute Configuration and Interactions with the Aldose Reductase by X-ray Crystallography

2000 ◽  
Vol 43 (12) ◽  
pp. 2479-2483 ◽  
Author(s):  
Mitsuru Oka ◽  
Yukiharu Matsumoto ◽  
Shigeru Sugiyama ◽  
Nobuaki Tsuruta ◽  
Masaaki Matsushima
Keyword(s):  
Aldose Reductase ◽  
Absolute Configuration ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
X Ray ◽  
X Ray Crystallography

X-ray structure of the V301L aldo–keto reductase 1B10 complexed with NADP+ and the potent aldose reductase inhibitor fidarestat: Implications for inhibitor binding and selectivity

2013 ◽  
Vol 202 (1-3) ◽  
pp. 178-185 ◽  
Author(s):  
Francesc Xavier Ruiz ◽  
Alexandra Cousido-Siah ◽  
André Mitschler ◽  
Jaume Farrés ◽  
Xavier Parés ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Inhibitor Binding ◽  
X Ray

Molecular Modeling of the Aldose Reductase-Inhibitor Complex Based on the X-ray Crystal Structure and Studies with Single-Site-Directed Mutants

2000 ◽  
Vol 43 (6) ◽  
pp. 1062-1070 ◽  
Author(s):  
Suresh B. Singh ◽  
Michael S. Malamas ◽  
Thomas C. Hohman ◽  
Ramaswamy Nilakantan ◽  
Deborah A. Carper ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Modeling ◽  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Single Site ◽  
X Ray ◽  
Inhibitor Complex

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

2006 ◽  
Vol 35 (7) ◽  
pp. 577-583 ◽  
Author(s):  
M. P. Blakeley ◽  
A. Mitschler ◽  
I. Hazemann ◽  
F. Meilleur ◽  
D. A. A. Myles ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
X Ray ◽  
Inhibitor Complex ◽  
Neutron Crystallography

Synthesis, absolute configuration and conformation of the aldose reductase inhibitor sorbinil

1985 ◽  
Vol 28 (11) ◽  
pp. 1716-1720 ◽  
Author(s):  
Reinhard Sarges ◽  
Jon Bordner ◽  
Beryl W. Dominy ◽  
Michael J. Peterson ◽  
Earl B. Whipple
Keyword(s):  
Aldose Reductase ◽  
Absolute Configuration ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Configuration And Conformation
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