Ultrahigh resolution drug design I: Details of interactions in human aldose reductase-inhibitor complex at 0.66 Å

2004 ◽  
Vol 55 (4) ◽  
pp. 792-804 ◽  
Author(s):  
E.I. Howard ◽  
R. Sanishvili ◽  
R.E. Cachau ◽  
A. Mitschler ◽  
B. Chevrier ◽  
...  
Keyword(s):  
Drug Design ◽  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Ultrahigh Resolution ◽  
Inhibitor Complex

Molecular Modeling of the Aldose Reductase-Inhibitor Complex Based on the X-ray Crystal Structure and Studies with Single-Site-Directed Mutants

2000 ◽  
Vol 43 (6) ◽  
pp. 1062-1070 ◽  
Author(s):  
Suresh B. Singh ◽  
Michael S. Malamas ◽  
Thomas C. Hohman ◽  
Ramaswamy Nilakantan ◽  
Deborah A. Carper ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Molecular Modeling ◽  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Single Site ◽  
X Ray ◽  
Inhibitor Complex

Comparison of hydrogen determination with X-ray and neutron crystallography in a human aldose reductase–inhibitor complex

2006 ◽  
Vol 35 (7) ◽  
pp. 577-583 ◽  
Author(s):  
M. P. Blakeley ◽  
A. Mitschler ◽  
I. Hazemann ◽  
F. Meilleur ◽  
D. A. A. Myles ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
X Ray ◽  
Inhibitor Complex ◽  
Neutron Crystallography

186-OR: Safety and Tolerability of the Next Generation Aldose Reductase Inhibitor (ARI) AT-001 Supports Initiation of the Pivotal Trial in Diabetic Cardiomyopathy (DbCM)

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 186-OR
Author(s):  
RICCARDO PERFETTI ◽  
FRANCESCA C. LAWSON ◽  
JULIO ROSENSTOCK ◽  
JAMES JANUZZI ◽  
SHOSHANA SHENDELMAN ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Diabetic Cardiomyopathy ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Pivotal Trial ◽  
Next Generation

462-P: AT-001, a Next Generation Aldose Reductase Inhibitor with Improved Selectivity and Specificity, Protects from Cellular Damage Associated with Hyperglycemia

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 462-P
Author(s):  
RICCARDO PERFETTI ◽  
GAUTHAM YEPURI ◽  
NOSIRUDEEN A. QUADRI ◽  
RAVICHANDRAN RAMASAMY ◽  
AMEEN F. GHANNAM ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Cellular Damage ◽  
Next Generation

Targeted co-delivery of the aldose reductase inhibitor epalrestat and chemotherapeutic doxorubicin via a redox-sensitive prodrug approach promotes synergistic tumor suppression

2019 ◽  
Vol 7 (7) ◽  
pp. 2889-2906 ◽  
Author(s):  
Venkatesh Teja Banala ◽  
Sandeep Urandur ◽  
Shweta Sharma ◽  
Madhu Sharma ◽  
Ravi P. Shukla ◽  
...  
Keyword(s):  
Aldose Reductase ◽  
Tumor Suppression ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Down Regulation ◽  
Redox Responsive

Redox responsive epalrestat prodrug micelles facilitate synergistic concentrations of doxorubicin with an advantage of CD44 down-regulation and reduced cardiotoxicity.

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