Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740):  A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

James A. Monn; Matthew J. Valli; Steven M. Massey; Rebecca A. Wright; Craig R. Salhoff; Bryan G. Johnson; Trevor Howe; Charles A. Alt; Gary A. Rhodes; Roger L. Robey; Kelly R. Griffey; Joseph P. Tizzano; Mary J. Kallman; David R. Helton; Darryle D. Schoepp

doi:10.1021/jm9606756

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

Journal of Medicinal Chemistry ◽

10.1021/jm9606756 ◽

1997 ◽

Vol 40 (4) ◽

pp. 528-537 ◽

Cited By ~ 299

Author(s):

James A. Monn ◽

Matthew J. Valli ◽

Steven M. Massey ◽

Rebecca A. Wright ◽

Craig R. Salhoff ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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ChemInform Abstract: Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvul

ChemInform ◽

10.1002/chin.199722076 ◽

2010 ◽

Vol 28 (22) ◽

pp. no-no

Author(s):

J. A. MONN ◽

M. J. VALLI ◽

S. M. MASSEY ◽

R. A. WRIGHT ◽

C. R. SALHOFF ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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A novel orally active Group 2 metabotropic glutamate receptor agonist

Neuroreport ◽

10.1097/00001756-199704140-00027 ◽

1997 ◽

Vol 8 (6) ◽

pp. 1463-1465 ◽

Cited By ~ 20

Author(s):

Ann Bond ◽

James A. Monn ◽

David Lodge

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Active Group ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Journal of Medicinal Chemistry ◽

10.1021/jm501612y ◽

2015 ◽

Vol 58 (4) ◽

pp. 1776-1794 ◽

Cited By ~ 42

Author(s):

James A. Monn ◽

Lourdes Prieto ◽

Lorena Taboada ◽

Concepcion Pedregal ◽

Junliang Hao ◽

...

Keyword(s):

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Metabotropic Glutamate ◽

Amino Terminal ◽

Domain Structures ◽

Glutamate Receptor Agonist ◽

Amino Terminal Domain

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Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

European Journal of Pharmacology ◽

10.1016/s0014-2999(00)00269-7 ◽

2000 ◽

Vol 397 (1) ◽

pp. R1-R2 ◽

Cited By ~ 76

Author(s):

Will P.J.M Spooren ◽

Fabrizio Gasparini ◽

Herman van der Putten ◽

Manuel Koller ◽

Shigetada Nakanishi ◽

...

Keyword(s):

Locomotor Activity ◽

Glutamate Receptor ◽

Knockout Mice ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist

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The Novel Metabotropic Glutamate Receptor Agonist 2 R ,4 R -APDC Potentiates Stimulation of Phosphoinositide Hydrolysis in the Rat Hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a Synergistic Interaction Between Group 1 and Group 2 Receptors

Neuropharmacology ◽

10.1016/s0028-3908(96)00121-9 ◽

1996 ◽

Vol 35 (12) ◽

pp. 1661-1672 ◽

Cited By ~ 74

Author(s):

D.D SCHOEPP ◽

C.R SALHOFF ◽

R.A WRIGHT ◽

B.G JOHNSON ◽

J.P BURNETT ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Rat Hippocampus ◽

The Novel ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Stimulation Of ◽

Group 1

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Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm000346k ◽

2000 ◽

Vol 43 (25) ◽

pp. 4893-4909 ◽

Cited By ~ 94

Author(s):

Atsuro Nakazato ◽

Toshihito Kumagai ◽

Kazunari Sakagami ◽

Ryoko Yoshikawa ◽

Yoshiko Suzuki ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Active Group ◽

Pharmacological Characterization ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists ◽

Orally Active

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Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.116574 ◽

2007 ◽

Vol 321 (3) ◽

pp. 1144-1153 ◽

Cited By ~ 52

Author(s):

Gentaroh Suzuki ◽

Toshifumi Kimura ◽

Akio Satow ◽

Naoki Kaneko ◽

Junko Fukuda ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 1 ◽

Orally Active

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The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease mice

Neurobiology of Disease ◽

10.1016/j.nbd.2012.03.025 ◽

2012 ◽

Vol 47 (1) ◽

pp. 75-91 ◽

Cited By ~ 25

Author(s):

A. Reiner ◽

D.C. Lafferty ◽

H.B. Wang ◽

N. Del Mar ◽

Y.P. Deng

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Group 2 ◽

Motor Abnormalities ◽

Glutamate Receptor Agonist

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(2S,1‘S,2‘R,3‘R)-2-(2‘-Carboxy-3‘-hydroxymethylcyclopropyl) Glycine Is a Highly Potent Group 2 and 3 Metabotropic Glutamate Receptor Agonist with Oral Activity

Journal of Medicinal Chemistry ◽

10.1021/jm030967o ◽

2004 ◽

Vol 47 (2) ◽

pp. 456-466 ◽

Cited By ~ 29

Author(s):

Iván Collado ◽

Concepción Pedregal ◽

Ana Belén Bueno ◽

Alicia Marcos ◽

Rosario González ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Oral Activity ◽

Group 2 ◽

Glutamate Receptor Agonist

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EFFECTS OF GROUP III METABOTROPIC GLUTAMATE RECEPTOR AGONIST ON THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS

10.26226/morressier.59b63e3fd462b8029238916e ◽

2017 ◽

Author(s):

Masashi Honda

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Micturition Reflex ◽

Metabotropic Glutamate ◽

Anesthetized Rats ◽

Glutamate Receptor Agonist

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