The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease mice

A. Reiner; D.C. Lafferty; H.B. Wang; N. Del Mar; Y.P. Deng

doi:10.1016/j.nbd.2012.03.025

The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease mice

Neurobiology of Disease ◽

10.1016/j.nbd.2012.03.025 ◽

2012 ◽

Vol 47 (1) ◽

pp. 75-91 ◽

Cited By ~ 25

Author(s):

A. Reiner ◽

D.C. Lafferty ◽

H.B. Wang ◽

N. Del Mar ◽

Y.P. Deng

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Group 2 ◽

Motor Abnormalities ◽

Glutamate Receptor Agonist

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ChemInform Abstract: Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvul

ChemInform ◽

10.1002/chin.199722076 ◽

2010 ◽

Vol 28 (22) ◽

pp. no-no

Author(s):

J. A. MONN ◽

M. J. VALLI ◽

S. M. MASSEY ◽

R. A. WRIGHT ◽

C. R. SALHOFF ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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Lack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice

European Journal of Pharmacology ◽

10.1016/s0014-2999(00)00269-7 ◽

2000 ◽

Vol 397 (1) ◽

pp. R1-R2 ◽

Cited By ~ 76

Author(s):

Will P.J.M Spooren ◽

Fabrizio Gasparini ◽

Herman van der Putten ◽

Manuel Koller ◽

Shigetada Nakanishi ◽

...

Keyword(s):

Locomotor Activity ◽

Glutamate Receptor ◽

Knockout Mice ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist

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Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

Journal of Medicinal Chemistry ◽

10.1021/jm9606756 ◽

1997 ◽

Vol 40 (4) ◽

pp. 528-537 ◽

Cited By ~ 299

Author(s):

James A. Monn ◽

Matthew J. Valli ◽

Steven M. Massey ◽

Rebecca A. Wright ◽

Craig R. Salhoff ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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The Novel Metabotropic Glutamate Receptor Agonist 2 R ,4 R -APDC Potentiates Stimulation of Phosphoinositide Hydrolysis in the Rat Hippocampus by 3,5-dihydroxyphenylglycine: Evidence for a Synergistic Interaction Between Group 1 and Group 2 Receptors

Neuropharmacology ◽

10.1016/s0028-3908(96)00121-9 ◽

1996 ◽

Vol 35 (12) ◽

pp. 1661-1672 ◽

Cited By ~ 74

Author(s):

D.D SCHOEPP ◽

C.R SALHOFF ◽

R.A WRIGHT ◽

B.G JOHNSON ◽

J.P BURNETT ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Rat Hippocampus ◽

The Novel ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Stimulation Of ◽

Group 1

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A novel orally active Group 2 metabotropic glutamate receptor agonist

Neuroreport ◽

10.1097/00001756-199704140-00027 ◽

1997 ◽

Vol 8 (6) ◽

pp. 1463-1465 ◽

Cited By ~ 20

Author(s):

Ann Bond ◽

James A. Monn ◽

David Lodge

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Active Group ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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(2S,1‘S,2‘R,3‘R)-2-(2‘-Carboxy-3‘-hydroxymethylcyclopropyl) Glycine Is a Highly Potent Group 2 and 3 Metabotropic Glutamate Receptor Agonist with Oral Activity

Journal of Medicinal Chemistry ◽

10.1021/jm030967o ◽

2004 ◽

Vol 47 (2) ◽

pp. 456-466 ◽

Cited By ~ 29

Author(s):

Iván Collado ◽

Concepción Pedregal ◽

Ana Belén Bueno ◽

Alicia Marcos ◽

Rosario González ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Oral Activity ◽

Group 2 ◽

Glutamate Receptor Agonist

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EFFECTS OF GROUP III METABOTROPIC GLUTAMATE RECEPTOR AGONIST ON THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS

10.26226/morressier.59b63e3fd462b8029238916e ◽

2017 ◽

Author(s):

Masashi Honda

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Micturition Reflex ◽

Metabotropic Glutamate ◽

Anesthetized Rats ◽

Glutamate Receptor Agonist

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Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(95)00013-j ◽

1995 ◽

Vol 5 (3) ◽

pp. 223-228 ◽

Cited By ~ 30

Author(s):

S. Richard Baker ◽

John Goldsworthy ◽

Raymond C. Harden ◽

Craig R. Salhoff ◽

Darryle D. Schoepp

Keyword(s):

Glutamate Receptor ◽

Pharmacological Activity ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Enzymatic Resolution ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist

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Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death

European Journal of Pharmacology ◽

10.1016/0014-2999(94)90624-6 ◽

1994 ◽

Vol 256 (1) ◽

pp. 109-112 ◽

Cited By ~ 90

Author(s):

Valeria Bruno ◽

Agata Copani ◽

Giuseppe Battaglia ◽

Rocco Raffaele ◽

Huruiko Shinozaki ◽

...

Keyword(s):

Protective Effect ◽

Glutamate Receptor ◽

Neuronal Death ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Excitotoxic Neuronal Death ◽

Glutamate Receptor Agonist

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LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia

Neuroscience Letters ◽

10.1016/s0304-3940(99)00663-1 ◽

1999 ◽

Vol 273 (3) ◽

pp. 191-194 ◽

Cited By ~ 51

Author(s):

Ann Bond ◽

Nella Ragumoorthy ◽

James A. Monn ◽

Caroline A. Hicks ◽

Mark A. Ward ◽

...

Keyword(s):

Glutamate Receptor ◽

Cerebral Ischaemia ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Focal Cerebral Ischaemia ◽

Metabotropic Glutamate ◽

Group Ii ◽

Glutamate Receptor Agonist

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