Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

James A. Monn; Lourdes Prieto; Lorena Taboada; Concepcion Pedregal; Junliang Hao; Matt R. Reinhard; Steven S. Henry; Paul J. Goldsmith; Christopher D. Beadle; Lesley Walton; Teresa Man; Helene Rudyk; Barry Clark; David Tupper; S. Richard Baker; Carlos Lamas; Carlos Montero; Alicia Marcos; Jaime Blanco; Mark Bures; David K. Clawson; Shane Atwell; Frances Lu; Jing Wang; Marijane Russell; Beverly A. Heinz; Xushan Wang; Joan H. Carter; Chuanxi Xiang; John T. Catlow; Steven Swanson; Helen Sanger; Lisa M. Broad; Michael P. Johnson; Kelly L. Knopp; Rosa M. A. Simmons; Bryan G. Johnson; David B. Shaw; David L. McKinzie

doi:10.1021/jm501612y

Synthesis and Pharmacological Characterization of C4-Disubstituted Analogs of 1S,2S,5R,6S-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: Identification of a Potent, Selective Metabotropic Glutamate Receptor Agonist and Determination of Agonist-Bound Human mGlu2 and mGlu3 Amino Terminal Domain Structures

Journal of Medicinal Chemistry ◽

10.1021/jm501612y ◽

2015 ◽

Vol 58 (4) ◽

pp. 1776-1794 ◽

Cited By ~ 42

Author(s):

James A. Monn ◽

Lourdes Prieto ◽

Lorena Taboada ◽

Concepcion Pedregal ◽

Junliang Hao ◽

...

Keyword(s):

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Metabotropic Glutamate ◽

Amino Terminal ◽

Domain Structures ◽

Glutamate Receptor Agonist ◽

Amino Terminal Domain

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ChemInform Abstract: Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvul

ChemInform ◽

10.1002/chin.199722076 ◽

2010 ◽

Vol 28 (22) ◽

pp. no-no

Author(s):

J. A. MONN ◽

M. J. VALLI ◽

S. M. MASSEY ◽

R. A. WRIGHT ◽

C. R. SALHOFF ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

Journal of Medicinal Chemistry ◽

10.1021/jm9606756 ◽

1997 ◽

Vol 40 (4) ◽

pp. 528-537 ◽

Cited By ~ 299

Author(s):

James A. Monn ◽

Matthew J. Valli ◽

Steven M. Massey ◽

Rebecca A. Wright ◽

Craig R. Salhoff ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

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EFFECTS OF GROUP III METABOTROPIC GLUTAMATE RECEPTOR AGONIST ON THE MICTURITION REFLEX IN URETHANE-ANESTHETIZED RATS

10.26226/morressier.59b63e3fd462b8029238916e ◽

2017 ◽

Author(s):

Masashi Honda

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Group Iii ◽

Micturition Reflex ◽

Metabotropic Glutamate ◽

Anesthetized Rats ◽

Glutamate Receptor Agonist

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Enzymatic resolution and pharmacological activity of the enantiomers of 3,5-dihydroxyphenylglycine, a metabotropic glutamate receptor agonist

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(95)00013-j ◽

1995 ◽

Vol 5 (3) ◽

pp. 223-228 ◽

Cited By ~ 30

Author(s):

S. Richard Baker ◽

John Goldsworthy ◽

Raymond C. Harden ◽

Craig R. Salhoff ◽

Darryle D. Schoepp

Keyword(s):

Glutamate Receptor ◽

Pharmacological Activity ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Enzymatic Resolution ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist

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Protective effect of the metabotropic glutamate receptor agonist, DCG-IV, against excitotoxic neuronal death

European Journal of Pharmacology ◽

10.1016/0014-2999(94)90624-6 ◽

1994 ◽

Vol 256 (1) ◽

pp. 109-112 ◽

Cited By ~ 90

Author(s):

Valeria Bruno ◽

Agata Copani ◽

Giuseppe Battaglia ◽

Rocco Raffaele ◽

Huruiko Shinozaki ◽

...

Keyword(s):

Protective Effect ◽

Glutamate Receptor ◽

Neuronal Death ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Excitotoxic Neuronal Death ◽

Glutamate Receptor Agonist

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LY379268, a potent and selective Group II metabotropic glutamate receptor agonist, is neuroprotective in gerbil global, but not focal, cerebral ischaemia

Neuroscience Letters ◽

10.1016/s0304-3940(99)00663-1 ◽

1999 ◽

Vol 273 (3) ◽

pp. 191-194 ◽

Cited By ~ 51

Author(s):

Ann Bond ◽

Nella Ragumoorthy ◽

James A. Monn ◽

Caroline A. Hicks ◽

Mark A. Ward ◽

...

Keyword(s):

Glutamate Receptor ◽

Cerebral Ischaemia ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Focal Cerebral Ischaemia ◽

Metabotropic Glutamate ◽

Group Ii ◽

Glutamate Receptor Agonist

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The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice

European Journal of Neuroscience ◽

10.1111/ejn.13539 ◽

2017 ◽

Vol 45 (7) ◽

pp. 912-921 ◽

Cited By ~ 5

Author(s):

Thomas Boerner ◽

Alexei M. Bygrave ◽

Jingkai Chen ◽

Anushka Fernando ◽

Stephanie Jackson ◽

...

Keyword(s):

Working Memory ◽

Receptor Antagonist ◽

Glutamate Receptor ◽

Knockout Mice ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Spatial Working Memory ◽

D2 Receptor ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist

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Potentiation of excitatory postsynaptic potentials by a metabotropic glutamate receptor agonist (1S,3R-ACPD) in frog spinal motoneurons

Brain Research ◽

10.1016/0006-8993(95)00580-j ◽

1995 ◽

Vol 689 (2) ◽

pp. 281-288 ◽

Cited By ~ 11

Author(s):

Hiroyuki Gotani ◽

Miyuki Kuno ◽

Fusao Nakamura ◽

Shiushi Matsuura

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Excitatory Postsynaptic Potentials ◽

Spinal Motoneurons ◽

Postsynaptic Potentials ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonist

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In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.124701 ◽

2007 ◽

Vol 323 (1) ◽

pp. 147-156 ◽

Cited By ~ 96

Author(s):

Gentaroh Suzuki ◽

Naohiro Tsukamoto ◽

Hiroshi Fushiki ◽

Aki Kawagishi ◽

Masayuki Nakamura ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Metabotropic Glutamate

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Reversal of Phencyclidine Effects by a Group II Metabotropic Glutamate Receptor Agonist in Rats

10.1126/science.281.5381.1349 ◽

1998 ◽

Vol 281 (5381) ◽

pp. 1349-1352 ◽

Cited By ~ 715

Author(s):

B. Moghaddam

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Metabotropic Glutamate ◽

Group Ii ◽

Glutamate Receptor Agonist

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