Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists

Atsuro Nakazato; Toshihito Kumagai; Kazunari Sakagami; Ryoko Yoshikawa; Yoshiko Suzuki; Shigeyuki Chaki; Hisanaka Ito; Takeo Taguchi; Shigetada Nakanishi; Shigeru Okuyama

doi:10.1021/jm000346k

Synthesis, SARs, and Pharmacological Characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent, Selective, and Orally Active Group II Metabotropic Glutamate Receptor Agonists

Journal of Medicinal Chemistry ◽

10.1021/jm000346k ◽

2000 ◽

Vol 43 (25) ◽

pp. 4893-4909 ◽

Cited By ~ 94

Author(s):

Atsuro Nakazato ◽

Toshihito Kumagai ◽

Kazunari Sakagami ◽

Ryoko Yoshikawa ◽

Yoshiko Suzuki ◽

...

Keyword(s):

Dicarboxylic Acid ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Active Group ◽

Pharmacological Characterization ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists ◽

Orally Active

Download Full-text

ChemInform Abstract: Design, Synthesis, and Pharmacological Characterization of (+)-2- Aminobicyclo(3.1.0)hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvul

ChemInform ◽

10.1002/chin.199722076 ◽

2010 ◽

Vol 28 (22) ◽

pp. no-no

Author(s):

J. A. MONN ◽

M. J. VALLI ◽

S. M. MASSEY ◽

R. A. WRIGHT ◽

C. R. SALHOFF ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

Download Full-text

Design, Synthesis, and Pharmacological Characterization of (+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY354740): A Potent, Selective, and Orally Active Group 2 Metabotropic Glutamate Receptor Agonist Possessing Anticonvulsant and Anxiolytic Properties

Journal of Medicinal Chemistry ◽

10.1021/jm9606756 ◽

1997 ◽

Vol 40 (4) ◽

pp. 528-537 ◽

Cited By ~ 299

Author(s):

James A. Monn ◽

Matthew J. Valli ◽

Steven M. Massey ◽

Rebecca A. Wright ◽

Craig R. Salhoff ◽

...

Keyword(s):

Glutamate Receptor ◽

Receptor Agonist ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Design Synthesis ◽

Metabotropic Glutamate ◽

Group 2 ◽

Glutamate Receptor Agonist ◽

Orally Active

Download Full-text

Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.106.116574 ◽

2007 ◽

Vol 321 (3) ◽

pp. 1144-1153 ◽

Cited By ~ 52

Author(s):

Gentaroh Suzuki ◽

Toshifumi Kimura ◽

Akio Satow ◽

Naoki Kaneko ◽

Junko Fukuda ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Metabotropic Glutamate ◽

Metabotropic Glutamate Receptor 1 ◽

Orally Active

Download Full-text

Depression of monosynaptic excitation of spinal motoneurons by novel metabotropic glutamate receptor agonists

Neuroscience Research Supplements ◽

10.1016/0921-8696(92)90783-w ◽

1992 ◽

Vol 17 ◽

pp. 84

Author(s):

Michiko Ishida ◽

Tomoko Saitoh ◽

Haruhiko Shinozaki

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Spinal Motoneurons ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Glutamate Receptor Agonists ◽

Monosynaptic Excitation

Download Full-text

Neuroprotection by metabotropic glutamate receptor agonists on kainate-induced degeneration of motor neurons in spinal cord slices from adult rat

Neuropharmacology ◽

10.1016/s0028-3908(99)00257-9 ◽

2000 ◽

Vol 39 (5) ◽

pp. 903-910 ◽

Cited By ~ 33

Author(s):

M Pizzi ◽

M Benarese ◽

F Boroni ◽

F Goffi ◽

A Valerio ◽

...

Keyword(s):

Spinal Cord ◽

Glutamate Receptor ◽

Motor Neurons ◽

Metabotropic Glutamate Receptor ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Adult Rat ◽

Glutamate Receptor Agonists

Download Full-text

Excitatory Effects of the Puberty-Initiating Peptide Kisspeptin and Group I Metabotropic Glutamate Receptor Agonists Differentiate Two Distinct Subpopulations of Gonadotropin-Releasing Hormone Neurons

Journal of Neuroscience ◽

10.1523/jneurosci.1225-08.2008 ◽

2008 ◽

Vol 28 (32) ◽

pp. 8003-8013 ◽

Cited By ~ 75

Author(s):

I. Dumalska ◽

M. Wu ◽

E. Morozova ◽

R. Liu ◽

A. van den Pol ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Gonadotropin Releasing Hormone ◽

Releasing Hormone ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Group I ◽

Glutamate Receptor Agonists

Download Full-text

In Vitro Pharmacological Characterization of Novel Isoxazolopyridone Derivatives as Allosteric Metabotropic Glutamate Receptor 7 Antagonists

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.107.124701 ◽

2007 ◽

Vol 323 (1) ◽

pp. 147-156 ◽

Cited By ~ 96

Author(s):

Gentaroh Suzuki ◽

Naohiro Tsukamoto ◽

Hiroshi Fushiki ◽

Aki Kawagishi ◽

Masayuki Nakamura ◽

...

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Pharmacological Characterization ◽

Metabotropic Glutamate

Download Full-text

Molecular Cloning, Functional Expression and Pharmacological Characterization of the Human Metabotropic Glutamate Receptor Type 2

European Journal of Neuroscience ◽

10.1111/j.1460-9568.1995.tb00666.x ◽

1995 ◽

Vol 7 (4) ◽

pp. 622-629 ◽

Cited By ~ 49

Author(s):

P. J. Flor ◽

K. Lindauer ◽

I. Püttner ◽

D. Rüegg ◽

S. Lukic ◽

...

Keyword(s):

Molecular Cloning ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Functional Expression ◽

Receptor Type ◽

Pharmacological Characterization ◽

Metabotropic Glutamate

Download Full-text

Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists

Brain Research ◽

10.1016/s0006-8993(99)01065-3 ◽

1999 ◽

Vol 821 (2) ◽

pp. 539-545 ◽

Cited By ~ 19

Author(s):

Michael P Johnson ◽

Maryjo Chamberlain ◽

Gerard M Kelly

Keyword(s):

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Phosphoinositide Hydrolysis ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Group I ◽

Glutamate Receptor Agonists

Download Full-text

Regulation of phosphoinositide turnover in neonatal rat cerebral cortex by group I- and II- selective metabotropic glutamate receptor agonists

British Journal of Pharmacology ◽

10.1038/sj.bjp.0701626 ◽

1998 ◽

Vol 123 (3) ◽

pp. 581-589 ◽

Cited By ~ 23

Author(s):

Rajendra Mistry ◽

Nicki Golding ◽

R A. John Challiss

Keyword(s):

Cerebral Cortex ◽

Glutamate Receptor ◽

Metabotropic Glutamate Receptor ◽

Neonatal Rat ◽

Rat Cerebral Cortex ◽

Receptor Agonists ◽

Metabotropic Glutamate ◽

Phosphoinositide Turnover ◽

Group I ◽

Glutamate Receptor Agonists

Download Full-text