Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids

Joseph P. Sanchez; John M. Domagala; Susan E. Hagen; Carl L. Heifetz; Marland P. Hutt; Jeffry B. Nichols; Ashok K. Trehan

doi:10.1021/jm00400a016

Quinolone antibacterial agents. Synthesis and structure-activity relationships of 8-substituted quinoline-3-carboxylic acids and 1,8-naphthyridine-3-carboxylic acids

Journal of Medicinal Chemistry ◽

10.1021/jm00400a016 ◽

1988 ◽

Vol 31 (5) ◽

pp. 983-991 ◽

Cited By ~ 89

Author(s):

Joseph P. Sanchez ◽

John M. Domagala ◽

Susan E. Hagen ◽

Carl L. Heifetz ◽

Marland P. Hutt ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Fluoronaphthyridines as antibacterial agents. 4. Synthesis and structure-activity relationships of 5-substituted 6-fluoro-7-(cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids

Journal of Medicinal Chemistry ◽

10.1021/jm00081a013 ◽

1992 ◽

Vol 35 (3) ◽

pp. 518-525 ◽

Cited By ~ 52

Author(s):

D. Bouzard ◽

P. Di Cesare ◽

M. Essiz ◽

J. P. Jacquet ◽

B. Ledoussal ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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7-Azetidinylquinolones as Antibacterial Agents. 2. Synthesis and Biological Activity of 7-(2,3-Disubstituted-1-azetidinyl)-4-oxoquinoline- and -1,8-naphthyridine-3-carboxylic Acids. Properties and Structure-Activity Relationships of Quinolones with an Azetidine Moiety

Journal of Medicinal Chemistry ◽

10.1021/jm00050a016 ◽

1994 ◽

Vol 37 (24) ◽

pp. 4195-4210 ◽

Cited By ~ 31

Author(s):

Jordi Frigola ◽

Antoni Torrens ◽

Jose A. Castrillo ◽

Josep Mas ◽

David Vano ◽

...

Keyword(s):

Biological Activity ◽

Carboxylic Acids ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Quantitative Structure-Activity Relationships of Antibacterial Agents, 7-Heterocyclic Amine Substituted 1-Cyclopropyl-6,8-difluoro-4-oxoquinoline-3-carboxylic Acids.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.41.126 ◽

1993 ◽

Vol 41 (1) ◽

pp. 126-131 ◽

Cited By ~ 22

Author(s):

Tetsuo OKADA ◽

Kiyoshi EZUMI ◽

Masumi YAMAKAWA ◽

Hisao SATO ◽

Teruji TSUJI ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Heterocyclic Amine ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Substituted 1

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ChemInform Abstract: 1,4-DIHYDRO-4-OXOPYRIDINECARBOXYLIC ACIDS AS ANTIBACTERIAL AGENTS. 2. SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 1,6,7-TRISUBSTITUTED 1,4-DIHYDRO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS, INCLUDING ENOXACIN, A NEW ANTIBACTERI

Chemischer Informationsdienst ◽

10.1002/chin.198432233 ◽

1984 ◽

Vol 15 (32) ◽

Author(s):

J. MATSUMOTO ◽

T. MIYAMOTO ◽

A. MINAMIDA ◽

Y. NISHIMURA ◽

H. EGAWA ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Quantitative Structure-Activity Relationships of Antibacterial Agents, 7-Heterocyclic Amine Substituted 1-Cyclopropyl-6,8-difluoro-4- oxoquinoline-3-carboxylic Acids.

ChemInform ◽

10.1002/chin.199325281 ◽

2010 ◽

Vol 24 (25) ◽

pp. no-no

Author(s):

T. OKADA ◽

K. EZUMI ◽

M. YAMAKAWA ◽

H. SATO ◽

T. TSUJI ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Heterocyclic Amine ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships ◽

Substituted 1

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ChemInform Abstract: Quinolone Antibacterial Agents. Synthesis and Structure-Activity Relationships of 8-Substituted Quinoline-3-carboxylic Acids (I) and 1,8-Naphthyridine-3-carboxylic Acids (II).

ChemInform ◽

10.1002/chin.198838211 ◽

1988 ◽

Vol 19 (38) ◽

Author(s):

J. P. SANCHEZ ◽

J. M. DOMAGALA ◽

S. E. HAGEN ◽

C. L. HEIFETZ ◽

M. P. HUTT ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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1,4-Dihydro-4-oxopyridinecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent

Journal of Medicinal Chemistry ◽

10.1021/jm00369a011 ◽

1984 ◽

Vol 27 (3) ◽

pp. 292-301 ◽

Cited By ~ 63

Author(s):

Junichi Matsumoto ◽

Teruyuki Miyamoto ◽

Akira Minamida ◽

Yoshiro Nishimura ◽

Hiroshi Egawa ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agent ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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ChemInform Abstract: Fluoronaphthyridines as Antibacterial Agents. Part 4. Synthesis and Structure-Activity Relationships of 5-Substituted 6-Fluoro-7-( cycloalkylamino)-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic Acids.

ChemInform ◽

10.1002/chin.199223185 ◽

2010 ◽

Vol 23 (23) ◽

pp. no-no

Author(s):

D. BOUZARD ◽

P. DI CESARE ◽

M. ESSIZ ◽

J. P. JACQUET ◽

B. LEDOUSSAL ◽

...

Keyword(s):

Carboxylic Acids ◽

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Structure−Activity Relationships of Novel 2-Substituted Quinazoline Antibacterial Agents

Journal of Medicinal Chemistry ◽

10.1021/jm9903500 ◽

1999 ◽

Vol 42 (22) ◽

pp. 4705-4713 ◽

Cited By ~ 156

Author(s):

Pei-Pei Kung ◽

Martin D. Casper ◽

Kimberley L. Cook ◽

Laura Wilson-Lingardo ◽

Lisa M. Risen ◽

...

Keyword(s):

Antibacterial Agents ◽

Structure Activity Relationships ◽

Structure Activity

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Synthesis, Biological Evaluation, and Structure−Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2

Journal of Medicinal Chemistry ◽

10.1021/jm960863w ◽

1997 ◽

Vol 40 (17) ◽

pp. 2694-2705 ◽

Cited By ~ 20

Author(s):

Matthias Lehr

Keyword(s):

Phospholipase A2 ◽

Carboxylic Acids ◽

Biological Evaluation ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity

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