Synthesis, Biological Evaluation, and Structure−Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2

Matthias Lehr

doi:10.1021/jm960863w

Synthesis, Biological Evaluation, and Structure−Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2

Journal of Medicinal Chemistry ◽

10.1021/jm960863w ◽

1997 ◽

Vol 40 (17) ◽

pp. 2694-2705 ◽

Cited By ~ 20

Author(s):

Matthias Lehr

Keyword(s):

Phospholipase A2 ◽

Carboxylic Acids ◽

Biological Evaluation ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity

Download Full-text

ChemInform Abstract: Synthesis, Biological Evaluation, and Structure-Activity Relationships of 3-Acylindole-2-carboxylic Acids as Inhibitors of the Cytosolic Phospholipase A2.

ChemInform ◽

10.1002/chin.199749143 ◽

2010 ◽

Vol 28 (49) ◽

pp. no-no

Author(s):

M. LEHR

Keyword(s):

Phospholipase A2 ◽

Carboxylic Acids ◽

Biological Evaluation ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity

Download Full-text

Structure−Activity Relationships of (4-Acylpyrrol-2-yl)alkanoic Acids as Inhibitors of the Cytosolic Phospholipase A2: Variation of the Substituents in Positions 1, 3, and 5

Journal of Medicinal Chemistry ◽

10.1021/jm970045j ◽

1997 ◽

Vol 40 (21) ◽

pp. 3381-3392 ◽

Cited By ~ 15

Author(s):

Matthias Lehr

Keyword(s):

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Alkanoic Acids

Download Full-text

Structure—Activity Relationship Studies of 1-Substituted 3-Dodecanoylindole-2-carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release in Intact Platelets.

ChemInform ◽

10.1002/chin.200323215 ◽

2003 ◽

Vol 34 (23) ◽

Author(s):

Klaus Griessbach ◽

Monika Klimt ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Carboxylic Acids ◽

Structure Activity Relationship ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Arachidonic Acid Release ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release

Download Full-text

ChemInform Abstract: Structure-Activity Relationships of (4-Acylpyrrol-2-yl)alkanoic Acids as Inhibitors of the Cytosolic Phospholipase A2: Variation of the Substituents in Positions 1, 3, and 5.

ChemInform ◽

10.1002/chin.199804105 ◽

2010 ◽

Vol 29 (4) ◽

pp. no-no

Author(s):

M. LEHR

Keyword(s):

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

Structure Activity Relationships ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Alkanoic Acids ◽

Abstract Structure

Download Full-text

Structure-Activity Relationship Studies of 1-Substituted 3-Dodecanoylindole-2-carboxylic Acids as Inhibitors of Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release in Intact Platelets

Archiv der Pharmazie ◽

10.1002/ardp.200290008 ◽

2002 ◽

Vol 335 (1112) ◽

pp. 547-555 ◽

Cited By ~ 6

Author(s):

Klaus Griessbach ◽

Monika Klimt ◽

Alwine Schulze Elfringhoff ◽

Matthias Lehr

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Carboxylic Acids ◽

Structure Activity Relationship ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Arachidonic Acid Release ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Acid Release

Download Full-text

Comparison of the Inhibition of the Cytosolic Phospholipase A2-Mediated Arachidonic Acid Release by Several Indole-2-carboxylic Acids and 3-(Pyrrol-2-yl)propionic Acids in Bovine and in Human Platelets

Archiv der Pharmazie ◽

10.1002/1521-4184(20009)333:9<312::aid-ardp312>3.0.co;2-y ◽

2000 ◽

Vol 333 (9) ◽

pp. 312-314 ◽

Cited By ~ 10

Author(s):

Matthias Lehr ◽

Alwine Schulze Elfringhoff

Keyword(s):

Arachidonic Acid ◽

Phospholipase A2 ◽

Carboxylic Acids ◽

Human Platelets ◽

Cytosolic Phospholipase A2 ◽

Arachidonic Acid Release ◽

Cytosolic Phospholipase ◽

Acid Release

Download Full-text

ChemInform Abstract: Structure-Activity Relationship Studies on (4-Acylpyrrol-2-yl)alkanoic Acids as Inhibitors of the Cytosolic Phospholipase A2: Variation of the Alkanoic Acid Substituent, the Acyl Chain, and the Position of the Pyrrole Nitrogen.

ChemInform ◽

10.1002/chin.199806148 ◽

2010 ◽

Vol 29 (6) ◽

pp. no-no

Author(s):

M. LEHR

Keyword(s):

Phospholipase A2 ◽

Acyl Chain ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Alkanoic Acid ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Alkanoic Acids ◽

Abstract Structure ◽

Pyrrole Nitrogen

Download Full-text

Structure-activity relationship studies on (4-acylpyrrol-2-yl)alkanoic acids as inhibitors of the cytosolic phospholipase A2: Variation of the alkanoic acid substituent, the acyl chain and the position of the pyrrole nitrogen

European Journal of Medicinal Chemistry ◽

10.1016/s0223-5234(99)80066-x ◽

1997 ◽

Vol 32 (10) ◽

pp. 805-814 ◽

Cited By ~ 10

Author(s):

M Lehr

Keyword(s):

Phospholipase A2 ◽

Acyl Chain ◽

Structure Activity Relationship ◽

Cytosolic Phospholipase A2 ◽

Activity Relationship ◽

Alkanoic Acid ◽

Cytosolic Phospholipase ◽

Structure Activity ◽

Alkanoic Acids ◽

Pyrrole Nitrogen

Download Full-text

Faculty Opinions recommendation of Cytosolic phospholipase A2 plays a key role in the pathogenesis of multiple sclerosis-like disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1016127.204243 ◽

2004 ◽

Author(s):

Guoping Feng

Keyword(s):

Multiple Sclerosis ◽

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

Cytosolic Phospholipase

Download Full-text

Modulation of cytosolic phospholipase A2 by PPAR activators in human preadipocytes

The Journal of Lipid Research ◽

10.1016/s0022-2275(20)31633-3 ◽

2001 ◽

Vol 42 (5) ◽

pp. 716-724

Author(s):

Yan J. Jiang ◽

Grant M. Hatch ◽

David Mymin ◽

Thomas Dembinski ◽

Edwin A. Kroeger ◽

...

Keyword(s):

Phospholipase A2 ◽

Cytosolic Phospholipase A2 ◽

Cytosolic Phospholipase ◽

Human Preadipocytes

Download Full-text