Synthesis and determination of antiviral activity of the 2'(3')-O-methyl derivatives of ribavirin (1-.beta.-D-ribofuranosyl-1,2,4-triazole-3-carboxamide)

1977 ◽  
Vol 20 (10) ◽  
pp. 1354-1356 ◽  
Author(s):  
L. Dudycz ◽  
D. Shugar ◽  
E. De Clercq ◽  
J. Descamps
Keyword(s):  
Antiviral Activity ◽  
Methyl Derivatives ◽  
Derivatives Of

Preparation, spectral properties and biological activities of 5-bromo-6-methyl-2'-deoxyuridine and 5-iodo-6-methyl-2'-deoxyuridine

1980 ◽  
Vol 45 (8) ◽  
pp. 2364-2370 ◽  
Author(s):  
Antonín Holý ◽  
Erik De Clercq
Keyword(s):  
Antiviral Activity ◽  
Spectral Properties ◽  
De Novo ◽  
Biological Activities ◽  
Rabbit Kidney ◽  
Kidney Cells ◽  
Cd Spectra ◽  
Methyl Derivatives ◽  
Primary Rabbit

Reaction of 3',5'-di-O-benzoyl-6-methyl-2'-deoxyuridine (IIa) with elementary bromine or iodine afforded 5-halogeno derivatives IIc and IId which on methanolysis gave 5-bromo-6-methyl-2'-deoxyurine (Ic) and 5-iodo-6-methyl-2'-deoxyurine (Id), respectively. The CD spectra of Ic, Id and 6-methyl-2'-deoxyuridine (Ia) are compared and discussed with regard to determination of the nucleoside conformation. Unlike 5-bromo- and 5-iodo-2'-deoxyuridine, the 6-methyl derivatives Ic and Id exhibit neither antibacterial nor antiviral activity. Nor do they exert any antimetabolic effect on the de novo DNA synthesis in primary rabbit kidney cells.

Synthesis of 1,2, and 9-methyl derivatives of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline and their antiviral activity

1987 ◽  
Vol 52 (3) ◽  
pp. 788-792 ◽  
Author(s):  
Stanislav Rádl ◽  
Viktor Zikán
Keyword(s):  
Influenza Virus ◽  
Antiviral Activity ◽  
Hydrobromic Acid ◽  
Encephalomyocarditis Virus ◽  
Methyl Derivative ◽  
Pyridine Hydrochloride ◽  
Methyl Derivatives ◽  
Derivatives Of

The paper describes syntheses of 4,9-dihydro-6-methoxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ia), its 1-methyl derivative (Ic), 1,9-dimethyl derivative (Ie), 2-methyl derivative (IIa), and 2,9-dimethyl derivative (IIc). Demethylation of these compounds with hydrobromic acid afforded 4,9-dihydro-6-hydroxy-3-methyl-4-oxo-1H(2H)-pyrazolo[3,4-b]quinoline (Ib), its 1-methyl derivative (Id), 1,9-dimethyl derivative (If), 2-methyl derivative (IIb), and 2,9-dimethyl derivative (IId) respectively. 4,9-Dihydro-6-hydroxy-3,9-dimethyl-4-oxo-1H-pyrazolo[3,4-b]quinoline (Ig) was prepared by demethylation of Ie and/or IIc with pyridine hydrochloride. The compounds prepared were tested for antiviral activity in vivo in mice against influenza virus A2-Hongkong and encephalomyocarditis virus.

Synthesis and antiviral activity of 2-amino[thio]methyl derivatives of 4,5-dihydroxybenzofuran

1987 ◽  
Vol 21 (2) ◽  
pp. 132-133
Author(s):  
A. N. Grinev ◽  
V. M. Lyubchanskaya ◽  
L. S. Sarkisova ◽  
S. A. Moshinets ◽  
E. A. Golovanova
Keyword(s):  
Antiviral Activity ◽  
Methyl Derivatives ◽  
Derivatives Of
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