Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry toward Heterocycles and Natural Products Edited by Albert Padwa (Emory University) and William H. Pearson (University of Michigan). The Chemistry of Heterocyclic Compounds. Volume 59. Series Edited by Edward Taylor and Peter Wipf. John Wiley & Sons, Inc.:  New York. 2002. xii + 940 pp. $425.00. ISBN 0-471-38726-6.

2002 ◽  
Vol 124 (42) ◽  
pp. 12633-12634
Author(s):  
Peter A. Jacobi
2021 ◽  
Author(s):  
Seema Thakur ◽  
Arunima Das ◽  
Tapas Das

The 1,3-dipolar cycloaddition reaction of nitrone is one of the most important methods for the synthesis of different sizes of heterocycles which have enormous applications in natural products, biologically active molecules and pharmaceuticals.


Author(s):  
Robert Speers

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed El Fal ◽  
Youssef Ramli ◽  
Abdelfettah Zerzouf ◽  
Ahmed Talbaoui ◽  
Youssef Bakri ◽  
...  

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR,13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains:Staphylococcus aureus,Enterococcus faecalis,Escherichia coli, andPseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL againstStaphylococcus aureusandStreptococcus fasciens.


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