Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry. Towards Heterocycles and Natural Products (Series: Chemistry of Heterocyclic Compounds, Vol. 59.). By Albert Padwa and William H. Pearson.

2003 ◽  
Vol 42 (38) ◽  
pp. 4569-4570
Author(s):  
Hiroyuki Suga
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Dipolar Cycloaddition

1,3-Dipolar cycloaddition of nitrones: synthesis of multisubstituted, diverse range of heterocyclic compounds

2021 ◽  
Author(s):  
Seema Thakur ◽  
Arunima Das ◽  
Tapas Das
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Cycloaddition Reaction ◽  
Biologically Active ◽  
Dipolar Cycloaddition ◽  
Diverse Range

The 1,3-dipolar cycloaddition reaction of nitrone is one of the most important methods for the synthesis of different sizes of heterocycles which have enormous applications in natural products, biologically active molecules and pharmaceuticals.

scholarly journals Synthesis and Antibacterial Activity of New Spiro[thiadiazoline-(pyrazolo[3,4-d]pyrimidine)] Derivatives

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammed El Fal ◽  
Youssef Ramli ◽  
Abdelfettah Zerzouf ◽  
Ahmed Talbaoui ◽  
Youssef Bakri ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Spectroscopic Data ◽  
Heterocyclic Compounds ◽  
Dipolar Cycloaddition ◽  
Bacterial Strains ◽  
Pyrimidine Derivatives ◽  
H Nmr ◽  
Biological Interest ◽  
Mic Value

New heterocyclic compounds spiroderivatives of allopurinol of biological interest were prepared from allopurinol via thionation and 1,3-dipolar cycloaddition and were produced in high to excellent yields. These compounds were characterized on the basis of spectral and spectroscopic data (1H NMR,13C, IR, and MS). The antibacterial activity of the synthesized products was studied using bacterial strains:Staphylococcus aureus,Enterococcus faecalis,Escherichia coli, andPseudomonas aeruginosa. Compounds having an ethyl group showed the best activity with MIC value of 31.25 µg/mL againstStaphylococcus aureusandStreptococcus fasciens.

Research Progress of N-Alkylation of Alcohol and Amine by "Hydrogen Reaction"

2021 ◽  
Vol 871 ◽  
pp. 312-317
Author(s):  
Si Min Feng ◽  
Qing Liu
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Amino Alcohols ◽  
New Method ◽  
Research Progress ◽  
Primary Alcohols ◽  
Ammonia Gas ◽  
Fine Chemical ◽  
Chemical Products ◽  
Amine Compounds

Amine compounds are widely found in natural products, pharmaceuticals and fine chemical products. Therefore, it is of great significance to develop methods for synthesizing amine compounds. Therefore, in recent years, a new method of synthesizing amines has been developed, namely "hydrogen borrowing reaction". This article reviews the alkylation of primary alcohols and amines, the cyclization of amino alcohols to form N-heterocyclic compounds, the reaction of diols and amines to form N-heterocyclic compounds, the reaction of alcohols and sulfonamides, and the reaction of alcohols and amines containing N heteroatoms , Alcohol and ammonia gas and ammonia to produce amine by hydrogen reaction research progress.

scholarly journals Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications

RSC Advances ◽  
2020 ◽  
Vol 10 (70) ◽  
pp. 42644-42681
Author(s):  
Manar Ahmed Fouad ◽  
Hamida Abdel-Hamid ◽  
Mohammed Salah Ayoup
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Cyclic Peptides ◽  
Ugi Reaction ◽  
Pharmaceutical Applications ◽  
Recent Advances

We highlight the recent advances of the Ugi reaction in the last two decades from 2000–2019, mainly in the synthesis of linear or cyclic peptides, heterocyclic compounds with versatile ring sizes, and natural products, as well as the enantioselective Ugi reactions.

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