Synthetic Applications of 1,3-Dipolar Cycloaddition Chemistry Toward Heterocycles and Natural Products Edited by A. Padwa (Emory University) and W. H. Pearson (University of Michigan). Wiley-Interscience, Hoboken, NJ. 2003. xii + 940 pp. 6 × 91/2in. $105 (paperback), $445 (hardcover). ISBN 0-471-28061-5.

2004 ◽  
Vol 67 (6) ◽  
pp. 1074-1074 ◽  
Author(s):  
Brian L. Pagenkopf
Keyword(s):  
Natural Products ◽  
Dipolar Cycloaddition ◽  
University Of Michigan ◽  
Emory University

Glycoconjugation of 4-Methylumbelliferone via “Click Chemistry”

2014 ◽  
Vol 881-883 ◽  
pp. 414-418
Author(s):  
Ru Chun Yang ◽  
Tao Hu ◽  
Ban Peng Cao ◽  
Xi Chen ◽  
Qiang Xiao
Keyword(s):  
Natural Products ◽  
Click Chemistry ◽  
High Yield ◽  
Dipolar Cycloaddition ◽  
Derivatives Of

A series of carbohydrate-conjugated 4-methylumbelliferone were synthesized using 1,3-dipolar cycloaddition “click chemistry” of the azide and alkyne. The reaction is straight forward and in high yield. The strategy will be useful for synthesizing glycoconjugated derivatives of natural products.

Recent Advances in the Chemistry of Doubly Activated Cyclopropanes: Synthesis and Reactivity

2019 ◽  
Vol 23 (3) ◽  
pp. 276-312 ◽  
Author(s):  
Purushothaman Gopinath ◽  
Srinivasan Chandrasekaran
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Electron Donor ◽  
Ring Opening ◽  
Dipolar Cycloaddition ◽  
Recent Advances ◽  
Donor Acceptor ◽  
Synthesis Reactions ◽  
Donor Substituent ◽  
Electron Donor Substituent

Diactivated cyclopropanes containing two geminal electron withdrawing groups, commonly called as ‘Doubly Activated Cyclopropanes’ are useful synthons for the synthesis of many interesting natural products and functionalized molecules. These geminal electron withdrawing groups (EWG’s) facilitate the regioselective ring opening of cyclopropanes by polarizing the C-C bond adjacent to it. This polarization also allows them to undergo 1,3 dipolar cycloaddition reactions when substituted with a suitable electron donor substituent at the adjacent carbon (donor-acceptor cyclopropanes) in the presence of suitable dipolarophiles. In this review, we discuss the recent advances in the chemistry of doubly activated cyclopropanes: their synthesis, reactions and applications in total synthesis.

scholarly journals Synthesis of Bioactive Fluoropyrrolidines via Copper(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides

2021 ◽  
Author(s):  
Xiao Xu ◽  
Longzhu Bao ◽  
Lu Ran ◽  
Zhenyan Yang ◽  
Dingce Yan ◽  
...  
Keyword(s):  
Natural Products ◽  
Building Blocks ◽  
Biologically Active ◽  
Azomethine Ylides ◽  
Dipolar Cycloaddition ◽  
Active Natural

Chiral pyrrolidinyl units are important building blocks in biologically active natural products and drugs, and the develpment of efficient methods for the synthesis of diverse structured pyrrolidine derivatives is of...

1,3-Dipolar cycloaddition of nitrones: synthesis of multisubstituted, diverse range of heterocyclic compounds

2021 ◽  
Author(s):  
Seema Thakur ◽  
Arunima Das ◽  
Tapas Das
Keyword(s):  
Natural Products ◽  
Heterocyclic Compounds ◽  
Cycloaddition Reaction ◽  
Biologically Active ◽  
Dipolar Cycloaddition ◽  
Diverse Range

The 1,3-dipolar cycloaddition reaction of nitrone is one of the most important methods for the synthesis of different sizes of heterocycles which have enormous applications in natural products, biologically active molecules and pharmaceuticals.

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