Tetranuclear Gadolinium(III) Porphyrin Complex as a Theranostic Agent for Multimodal Imaging and Photodynamic Therapy

2014 ◽  
Vol 53 (8) ◽  
pp. 4184-4191 ◽  
Author(s):  
Jian Luo ◽  
Li-Feng Chen ◽  
Ping Hu ◽  
Zhong-Ning Chen
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging ◽  
Porphyrin Complex ◽  
Theranostic Agent

Self-assembled gold nanostar–NaYF4:Yb/Er clusters for multimodal imaging, photothermal and photodynamic therapy

2016 ◽  
Vol 4 (25) ◽  
pp. 4455-4461 ◽  
Author(s):  
Liangcan He ◽  
Joseph Dragavon ◽  
Suehyun Cho ◽  
Chenchen Mao ◽  
Adem Yildirim ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging ◽  
Grand Challenge ◽  
Gold Nanostar ◽  
Self Assembled

A grand challenge for medicine is to develop tools to selectively image and treat diseased cells.

Folic Acid Functionalized Chlorin e6-Superparamagnetic Iron Oxide Nanocarriers as a Theranostic Agent for MRI-Guided Photodynamic Therapy

2021 ◽  
Vol 17 (2) ◽  
pp. 205-215
Author(s):  
Zhenbo Sun ◽  
Mingfang Luo ◽  
Jia Li ◽  
Ailing Wang ◽  
Xucheng Sun ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Folic Acid ◽  
Iron Oxide ◽  
Near Infrared ◽  
Biological Fluids ◽  
Superparamagnetic Iron Oxide ◽  
Chlorin E6 ◽  
Theranostic Agent

Imaging-guided cancer theranostic is a promising strategy for cancer diagnostic and therapeutic. Photodynamic therapy (PDT), as an approved treatment modality, is limited by the poor solubility and dispersion of photosensitizers (PS) in biological fluids. Herein, it is demonstrated that superparamagnetic iron oxide (SPIO)-based nanoparticles (SCFs), prepared by conjugated with Chlorin e6 (Ce6) and modified with folic acid (FA) on the surface, can be used as versatile drug delivery vehicles for effective PDT. The nanoparticles are great carriers for photosensitizer Ce6 with an extremely high loading efficiency. In vitro fluorescence imaging and in vivo magnetic resonance imaging (MRI) results indicated that SCFs selectively accumulated in tumor cells. Under near-infrared laser irradiation, SCFs were confirmed to be capable of inducing low cell viability of RM-1 cells In vitro and displaying efficient tumor ablation with negligible side effects in tumor-bearing mice models.

Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

scholarly journals Single-Component Bismuth Nanoparticles as a Theranostic Agent for Multimodal Imaging-Guided Glioma Therapy

2019 ◽  
Vol 17 ◽  
pp. 619-627 ◽  
Author(s):  
Shu-Ting Lu ◽  
Dan Xu ◽  
Ru-Fang Liao ◽  
Jia-Zhen Luo ◽  
Yu-Hang Liu ◽  
...  
Keyword(s):  
Multimodal Imaging ◽  
Single Component ◽  
Bismuth Nanoparticles ◽  
Theranostic Agent

A nanosystem loaded with perfluorohexane and rose bengal coupled upconversion nanoparticles for multimodal imaging and synergetic chemo-photodynamic therapy of cancer

2020 ◽  
Vol 8 (9) ◽  
pp. 2488-2506 ◽  
Author(s):  
Hai-yan Wang ◽  
Li Hou ◽  
Hai-liang Li ◽  
Xu Wang ◽  
Yang Cao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Laser Irradiation ◽  
Rose Bengal ◽  
Multimodal Imaging ◽  
Upconversion Nanoparticles ◽  
Photodynamic Therapy Of Cancer ◽  
Targeted Release

A novel nanosystem (FURH-PFH-NPs) combined with LIFU and laser irradiation realized multimodal imaging, targeted release of HCPT, UCNPs-RB and synergetic chemo-photodynamic therapy of cancer.

scholarly journals A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy

2016 ◽  
Vol 15 (10) ◽  
pp. 1227-1238 ◽  
Author(s):  
H. Pye ◽  
M. A. Butt ◽  
H. W. Reinert ◽  
A. Maruani ◽  
J. P. M. Nunes ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Surgical Resection ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
Fab Fragment ◽  
Theranostic Agent

This work describes production of a HER2 targeting antibody Fab fragment dual conjugated for both near-infrared fluorescent imaging and photodynamic therapy.

A folate-conjugated platinum porphyrin complex as a new cancer-targeting photosensitizer for photodynamic therapy

2019 ◽  
Vol 17 (21) ◽  
pp. 5367-5374 ◽  
Author(s):  
Mengqian Yang ◽  
Jingran Deng ◽  
Ding Guo ◽  
Jie Zhang ◽  
Lixia Yang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Singlet Oxygen ◽  
Cancer Targeting ◽  
Porphyrin Complex ◽  
Platinum Porphyrin ◽  
Targeting Ability

A new folate-conjugated platinum porphyrin complex was synthesized, which displayed high singlet oxygen quantum yield and strong targeting ability.

scholarly journals A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

2020 ◽  
Vol 32 (28) ◽  
pp. 2003128
Author(s):  
Yifan Zhang ◽  
Shaowei Bo ◽  
Tao Feng ◽  
Xialing Qin ◽  
Yilin Wan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging

A Versatile Theranostic Nanoemulsion for Architecture‐Dependent Multimodal Imaging and Dually Augmented Photodynamic Therapy

2019 ◽  
Vol 31 (21) ◽  
pp. 1806444 ◽  
Author(s):  
Yifan Zhang ◽  
Shaowei Bo ◽  
Tao Feng ◽  
Xialing Qin ◽  
Yilin Wan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Multimodal Imaging
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