Phototherapy and multimodal imaging of cancers based on perfluorocarbon nanomaterials

2021 ◽  
Author(s):  
Zhaoguo Han ◽  
xianshuang tu ◽  
Lina Qiao ◽  
Yige Sun ◽  
Zibo Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Multimodal Imaging

Phototherapy, such as photodynamic therapy (PDT) and photothermal therapy (PTT) possesses unique characteristics of non-invasiveness and minimal side effects in cancer treatment, compared with conventional therapies. However, the ubiquitous tumor...

scholarly journals Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics

2018 ◽  
Vol 6 (4) ◽  
pp. 746-765 ◽  
Author(s):  
Houjuan Zhu ◽  
Penghui Cheng ◽  
Peng Chen ◽  
Kanyi Pu
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Spatial Resolution ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Recent Progress ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Ablation Efficiency ◽  
Excellent Spatial Resolution

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue.

scholarly journals A covalent organic framework as a nanocarrier for synergistic phototherapy and immunotherapy

2020 ◽  
Vol 8 (25) ◽  
pp. 5451-5459 ◽  
Author(s):  
Ying Zhou ◽  
Sainan Liu ◽  
Chunling Hu ◽  
Lihan Cai ◽  
Maolin Pang
Keyword(s):  
Photodynamic Therapy ◽  
Local Recurrence ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Tumor Metastasis ◽  
Primary Tumors ◽  
Treatment Methods ◽  
Covalent Organic Framework ◽  
Organic Framework

As traditional cancer treatment methods, photodynamic therapy (PDT) and photothermal therapy (PTT) can eliminate primary tumors, but they cannot inhibit extensive tumor metastasis and local recurrence.

A Near-Infrared Small Molecule Coupled with Rigidness and Flexibility for High-Performance Multimodal Imaging-Guided Photodynamic and Photothermal Synergistic Therapy

2021 ◽  
Author(s):  
Xiaozhen Li ◽  
Fang Fang ◽  
Bo Sun ◽  
Chao YIN ◽  
Jihua Tan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Clinical Application ◽  
Small Molecule ◽  
Photothermal Therapy ◽  
Multimodal Imaging ◽  
High Performance ◽  
Near Infrared ◽  
The Other ◽  
Lesion Site ◽  
Comprehensive Information

Photodynamic therapy (PDT) synergized photothermal therapy (PTT) shows superior clinical application prospect than single PDT or PTT. On the other hand, multimodal imaging can delineate comprehensive information of lesion site...

scholarly journals The Development of Ru(II)-Based Photoactivated Chemotherapy Agents

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5679
Author(s):  
Yongjie Chen ◽  
Lijuan Bai ◽  
Pu Zhang ◽  
Hua Zhao ◽  
Qianxiong Zhou
Keyword(s):  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Anticancer Activity ◽  
High Selectivity ◽  
Treatment Method ◽  
Temporal Control ◽  
Ligand Dissociation ◽  
Spatio Temporal ◽  
Chemotherapy Agents

Photoactivated chemotherapy (PACT) is a novel cancer treatment method that has drawn increasing attention due to its high selectivity and low side effects by spatio-temporal control of irradiation. Compared with photodynamic therapy (PDT), oxygen-independent PACT is more suitable for treating hypoxic tumors. By finely tuning ligand structures and coordination configurations, many Ru(II) complexes can undergo photoinduced ligand dissociation, and the resulting Ru(II) aqua species and/or free ligands may have anticancer activity, showing their potential as PACT agents. In this mini-review, we summarized the progress in Ru(II)-based PACT agents, as well as challenges that researchers in this field still face.

scholarly journals Enhancing Breast Cancer Treatment Using a Combination of Cannabidiol and Gold Nanoparticles for Photodynamic Therapy

2019 ◽  
Vol 20 (19) ◽  
pp. 4771 ◽  
Author(s):  
Dimakatso R. Mokoena ◽  
Blassan P. George ◽  
Heidi Abrahamse
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Side Effects ◽  
Cancer Treatment ◽  
Gold Nanoparticle ◽  
Cannabis Sativa ◽  
Minimal Risk ◽  
Positive Effects ◽  
Immunological Factors

Indisputably, cancer is a global crisis that requires immediate intervention. Despite the use of conventional treatments over the past decades, it is acceptable to admit that these are expensive, invasive, associated with many side effects and, therefore, a reduced quality of life. One of the most possible solutions to this could be the use of gold nanoparticle (AuNP) conjugated photodynamic therapy (PDT) in combination with cannabidiol (CBD), a Cannabis derivative from the Cannabis sativa. Since the use of Cannabis has always been associated with recreation and psychoactive qualities, the positive effects of Cannabis or its derivatives on cancer treatment have been misunderstood and hence misinterpreted. On the other hand, AuNP-PDT is the most favoured form of treatment for cancer, due to its augmented specificity and minimal risk of side effects compared to conventional treatments. However, its use requires the consideration of several physical, biologic, pharmacologic and immunological factors, which may hinder its effectiveness if not taken into consideration. In this review, the role of gold nanoparticle mediated PDT combined with CBD treatment on breast cancer cells will be deliberated.

scholarly journals Inorganic Nanoparticles for Cancer Treatment

2020 ◽  
Author(s):  
Heidi Abrahamse ◽  
Hanieh Montaseri ◽  
Cherie Kruger
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Reactive Oxygen ◽  
Inorganic Nanoparticles ◽  
Future Perspectives ◽  
The Past ◽  
Photosensitizing Agents

The application of porphyrins and their derivatives have been investigated extensively over the past years for phototherapy cancer treatment. Phototherapeutic Porphyrins have the ability to generate high levels of reactive oxygen with a low dark toxicity and these properties have made them robust photosensitizing agents. In recent years, Porphyrins have been combined with various nanomaterials in order to improve their bio-distribution. These combinations allow for nanoparticles to enhance photodynamic therapy (PDT) cancer treatment and adding additional nanotheranostics (photothermal therapy—PTT) as well as enhance photodiagnosis (PDD) to the reaction. This review examines various porphyrin-based inorganic nanoparticles developed for phototherapy nanotheranostic cancer treatment over the last three years (2017 to 2020). Furthermore, current challenges in the development and future perspectives of porphyrin-based nanomedicines for cancer treatment are also highlighted.

scholarly journals Strategies for Cancer Treatment Based on Photonic Nanomedicine

Materials ◽  
2021 ◽  
Vol 14 (6) ◽  
pp. 1435
Author(s):  
Sueli Aparecida de Oliveira ◽  
Roger Borges ◽  
Derval dos Santos Rosa ◽  
Ana Carolina Santos de Souza ◽  
Amedea B. Seabra ◽  
...  
Keyword(s):  
Side Effects ◽  
Cancer Treatment ◽  
Spatial Resolution ◽  
Photothermal Therapy ◽  
Web Of Science ◽  
Materials Science ◽  
Future Perspectives ◽  
Cancer Treatments ◽  
Temporal And Spatial ◽  
Materials Used

Traditional cancer treatments, such as surgery, radiotherapy, and chemotherapy, are still the most effective clinical practice options. However, these treatments may display moderate to severe side effects caused by their low temporal or spatial resolution. In this sense, photonic nanomedicine therapies have been arising as an alternative to traditional cancer treatments since they display more control of temporal and spatial resolution, thereby yielding fewer side effects. In this work, we reviewed the challenge of current cancer treatments, using the PubMed and Web of Science database, focusing on the advances of three prominent therapies approached by photonic nanomedicine: (i) photothermal therapy; (ii) photodynamic therapy; (iii) photoresponsive drug delivery systems. These photonic nanomedicines act on the cancer cells through different mechanisms, such as hyperthermic effect and delivery of chemotherapeutics and species that cause oxidative stress. Furthermore, we covered the recent advances in materials science applied in photonic nanomedicine, highlighting the main classes of materials used in each therapy, their applications in the context of cancer treatment, as well as their advantages, limitations, and future perspectives. Finally, although some photonic nanomedicines are undergoing clinical trials, their effectiveness in cancer treatment have already been highlighted by pre-clinical studies.

scholarly journals Recent Advances in Porphyrin-Based Inorganic Nanoparticles for Cancer Treatment

2020 ◽  
Vol 21 (9) ◽  
pp. 3358 ◽  
Author(s):  
Hanieh Montaseri ◽  
Cherie Ann Kruger ◽  
Heidi Abrahamse
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Reactive Oxygen ◽  
Inorganic Nanoparticles ◽  
Future Perspectives ◽  
The Past ◽  
Recent Advances ◽  
Photosensitizing Agents

The application of porphyrins and their derivatives have been investigated extensively over the past years for phototherapy cancer treatment. Phototherapeutic Porphyrins have the ability to generate high levels of reactive oxygen with a low dark toxicity and these properties have made them robust photosensitizing agents. In recent years, Porphyrins have been combined with various nanomaterials in order to improve their bio-distribution. These combinations allow for nanoparticles to enhance photodynamic therapy (PDT) cancer treatment and adding additional nanotheranostics (photothermal therapy—PTT) as well as enhance photodiagnosis (PDD) to the reaction. This review examines various porphyrin-based inorganic nanoparticles developed for phototherapy nanotheranostic cancer treatment over the last three years (2017 to 2020). Furthermore, current challenges in the development and future perspectives of porphyrin-based nanomedicines for cancer treatment are also highlighted.

scholarly journals Nanoparticle Systems for Cancer Phototherapy: An Overview

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3132
Author(s):  
Thais P. Pivetta ◽  
Caroline E. A. Botteon ◽  
Paulo A. Ribeiro ◽  
Priscyla D. Marcato ◽  
Maria Raposo
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Photodynamic Therapy ◽  
Cancer Treatment ◽  
Photothermal Therapy ◽  
Mechanisms Of Action ◽  
Inorganic Nanoparticles ◽  
Oxygen Species ◽  
Non Invasive ◽  
The Past

Photodynamic therapy (PDT) and photothermal therapy (PTT) are photo-mediated treatments with different mechanisms of action that can be addressed for cancer treatment. Both phototherapies are highly successful and barely or non-invasive types of treatment that have gained attention in the past few years. The death of cancer cells because of the application of these therapies is caused by the formation of reactive oxygen species, that leads to oxidative stress for the case of photodynamic therapy and the generation of heat for the case of photothermal therapies. The advancement of nanotechnology allowed significant benefit to these therapies using nanoparticles, allowing both tuning of the process and an increase of effectiveness. The encapsulation of drugs, development of the most different organic and inorganic nanoparticles as well as the possibility of surfaces’ functionalization are some strategies used to combine phototherapy and nanotechnology, with the aim of an effective treatment with minimal side effects. This article presents an overview on the use of nanostructures in association with phototherapy, in the view of cancer treatment.

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