Synthesis of S-alkyl and S-acyl derivatives of mercaptoundecahydrododecaborate, a possible boron carrier for neutron capture therapy

1993 ◽  
Vol 32 (11) ◽  
pp. 2276-2278 ◽  
Author(s):  
Detlef Gabel ◽  
Detlef Moller ◽  
Sven Harfst ◽  
Jens Roesler ◽  
Hartmut Ketz
Keyword(s):  
Neutron Capture ◽  
Neutron Capture Therapy ◽  
Derivatives Of ◽  
Acyl Derivatives

Polyhedral boron derivatives of porphyrins and phthalocyanines

2001 ◽  
Vol 05 (11) ◽  
pp. 767-781 ◽  
Author(s):  
VLADIMIR I. BREGADZE ◽  
IGOR B. SIVAEV ◽  
DETLEF GABEL ◽  
DIETER WÖHRLE
Keyword(s):  
Neutron Capture ◽  
Tumor Therapy ◽  
The Other ◽  
Medical Applications ◽  
Neutron Capture Therapy ◽  
Current Interest ◽  
Boron Compounds ◽  
Other Hand ◽  
The One ◽  
Derivatives Of

The synthesis of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units connected covalently in one molecule is reviewed. The importance of these compounds arises, on the one hand, from the use of polyhedral boron derivatives in neutron capture therapy for cancer; on the other hand, porphyrins and phthalocyanines are known as photosensitizers in photodynamic tumor therapy. Current interest in the binding of polyhedral boron compounds to porphyrins and phthalocyanines is due to the observation that porphyrins and phthalocyanines show improved uptake and good persistence in tissues. Medical applications of compounds containing polyhedral boron cages and porphyrin or phthalocyanine units in one molecule are briefly discussed.

scholarly journals Synthesis and characterization of azanonaborane-containing purine derivatives for boron neutron capture therapy

2008 ◽  
Vol 6 (2) ◽  
pp. 154-160
Author(s):  
Afaf Genady ◽  
Mohamed El-Zaria ◽  
Detlef Gabel
Keyword(s):  
Boron Neutron Capture Therapy ◽  
Neutron Capture ◽  
Imidazole Ring ◽  
Pyrimidine Ring ◽  
Neutron Capture Therapy ◽  
Reaction Conditions ◽  
Ligand Exchange Reaction ◽  
Boron Neutron Capture ◽  
Derivatives Of

AbstractDerivatives of purine, adenine, guanine, and 2,6-diaminopurine linked to the azanonaborane (B8N cluster) have been prepared, for possible use as powerful agents for boron neutron capture therapy (BNCT). The synthesis was carried out via a ligand exchange reaction. The exo-NH2R group of the azanonaborane of the type [(RH2N)B8H11NHR] can be exchanged by one hetero-nitrogen atom of the pyrimidine ring, and except for guanine, also by an N atom of the imidazole ring. The identity of the products was confirmed by NMR, elemental analysis, IR, and mass spectrometry. No reaction was found to occur with caffeine and theophylline under the same reaction conditions.

Reactions of oxonium derivatives of (B12H12)2- with phenoles, and synthesis and photochemical properties of a phthalocyanine containing four (B12H12)2- groups

2006 ◽  
Vol 10 (11) ◽  
pp. 1293-1300 ◽  
Author(s):  
Andrej Semioshkin ◽  
Olga Tsaryova ◽  
Olga Zhidkova ◽  
Vladimir Bregadze ◽  
Dieter Wöhrle
Keyword(s):  
Photocatalytic Activity ◽  
Neutron Capture ◽  
Tumor Therapy ◽  
High Yield ◽  
Neutron Capture Therapy ◽  
Boron Neutron Capture ◽  
Oxonium Derivatives ◽  
Photochemical Properties ◽  
High Yields ◽  
Derivatives Of

The reactions of dodecahydro-closo-dodecaborate oxonium derivatives with various phenols resulted in phenoxy-undecahydro-closo-dodecaborates in high yields. Using this method, a phthalocyanine zinc(II) complex containing four ( B 12 H 12)2- species was prepared in high yield. The compound shows good photocatalytic activity. The combination of boron cages and phthalocyanines makes this compound useful for boron neutron capture therapy for cancer and photodynamic tumor therapy.

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